TY - JOUR
T1 - Prepubertal unilateral gynecomastia and the presence of 47,XXY mosaicism in breast epithelial cells
T2 - a case report
AU - Andersen, Peter Stemann
AU - Petersen, Bodil Laub
AU - Juul, Anders
AU - Andersen, Mikael
PY - 2013/2
Y1 - 2013/2
N2 - Breast enlargement in prepubertal boys is a rare condition. This case report describes an otherwise healthy 3-year old non-obese boy who developed a large unilateral cystic breast mass measuring approximately 9 × 6 × 4 cm. The mass was initially treated as a lymphatic malformation, and sclerotherapy with Picibanil® (OK-432) was attempted without any detectable effect on size. The mass was later excised. The pathological examination revealed mammary gland tissue suggestive of idiopathic gynecomastia. FISH revealed 47, XXY mosaicism in the abnormal breast epithelial cells, but not in peripheral blood lymphocytes.
AB - Breast enlargement in prepubertal boys is a rare condition. This case report describes an otherwise healthy 3-year old non-obese boy who developed a large unilateral cystic breast mass measuring approximately 9 × 6 × 4 cm. The mass was initially treated as a lymphatic malformation, and sclerotherapy with Picibanil® (OK-432) was attempted without any detectable effect on size. The mass was later excised. The pathological examination revealed mammary gland tissue suggestive of idiopathic gynecomastia. FISH revealed 47, XXY mosaicism in the abnormal breast epithelial cells, but not in peripheral blood lymphocytes.
U2 - 10.1016/j.jpedsurg.2012.11.051
DO - 10.1016/j.jpedsurg.2012.11.051
M3 - Journal article
C2 - 23414896
SN - 0022-3468
VL - 48
SP - e21-3
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
IS - 2
ER -