Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer

Hans Jørgen Nielsen; Ib Jarle Christensen; Steen Sørensen; Flemming Moesgaard; Nils Brünner; Svend Schulze; Jens Thorup; Peer Wille-Jørgensen; Erik Bentzen; Lars Banke; Dorthe Froberg; Finn W. Henriksen; Poul Crone; Peter Hesselfeldt; Bo Hempel-Sparsø; Karen Lindorff Larsen; Torsten Asmussen; Jørgen Heiner; Ole Hart Hansen; Henrik Flyger; Per Jess; Jørgen Iversen; Jørgen La Cour Andersen; Bo Vennits; Janne H. Hammer; Anders Fischer; Hanne Galatius; Lars Naver; Dorthe Teilum; Leif Holbraad; Ole Iversen; Jens Nymark; Ole Roikjær; Leif Palm; Kirsten C. Rasmussen; Jørn Friis; Charlotte Lanng; Henrik Ovesen; Niels Chr Jensen; Niels Hoffman; Torben Larse; Jørgen Packler

doi:10.1007/BF02725342

Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer

Hans Jørgen Nielsen^*, Ib Jarle Christensen, Steen Sørensen, Flemming Moesgaard, Nils Brünner, Svend Schulze, Jens Thorup, Peer Wille-Jørgensen, Erik Bentzen, Lars Banke, Dorthe Froberg, Finn W. Henriksen, Poul Crone, Peter Hesselfeldt, Bo Hempel-Sparsø, Karen Lindorff Larsen, Torsten Asmussen, Jørgen Heiner, Ole Hart Hansen, Henrik FlygerPer Jess, Jørgen Iversen, Jørgen La Cour Andersen, Bo Vennits, Janne H. Hammer, Anders Fischer, Hanne Galatius, Lars Naver, Dorthe Teilum, Leif Holbraad, Ole Iversen, Jens Nymark, Ole Roikjær, Leif Palm, Kirsten C. Rasmussen, Jørn Friis, Charlotte Lanng, Henrik Ovesen, Niels Chr Jensen, Niels Hoffman, Torben Larse, Jørgen Packler

^*Corresponding author for this work

104 Citations (Scopus)

Abstract

Background: Preoperative plasma plasminogen activator inhibitor-1 (PAI-1) is a prognostic variable in patients with colorectal cancer. It has been suggested, however, that plasma PAI-1 is a nonspecific prognostic parameter similar to the acute-phase reactant C-reactive protein (CRP). In the present study we analyzed the association between plasma PAI-1 and serum CRP in patients scheduled for elective resection of colorectal cancer. In addition, the prognostic value of PAI-1 and CRP was studied in this patient cohort. Methods: PAI-1 and CRP were analyzed in citrated plasma and serum, respectively, obtained preoperatively from 594 patients. Patients who required preoperative blood transfusion received SAGM blood, in which soluble PAI-1 is not present. None of the patients received pre- or postoperative adjuvant chemotherapy, and all were followed in the outpatient clinic for at least 5 years or until death. The association of PAI-1 and CRP, respectively, with survival was tested using the median value of PAI-1 and the upper normal limit for CRP. Analyses were performed by inclusion of all patients, and in the subgroup of patients, who underwent curative resection. Results: The median follow-up period was 6.8 (5.4-7.9) years. The median value of plasma PAI-1 was 35.8 ng/ml, and values greater than 94 nmol/L identified patients with increased CRP levels. Comparison of the molecules showed that PAI-1 was weakly correlated with CRP (r = .26; P <.0001). Both molecules showed a Dukes independent distribution. In univariate survival analyses high levels of PAI-1 were found associated with poor prognosis and low levels with good prognosis (P = .02, HR: 1.3). Similarly, high levels of CRP were found associated with poor prognosis and low levels with good prognosis (P <.0001, HR: 1.9). In a multivariate statistical analysis including Dukes classification, gender, age, tumor location, perioperative blood transfusion, PAI-1 and CRP, plasma PAI-1 was a dependent prognostic variable, while serum CRP (P <.0001; HR: 1.4; 95% CI: 1.3-1.5) was found to be a Dukes independent prognostic variable. Similar analyses, excluding patients with Dukes, D disease showed serum CRP to be an independent prognostic variable (P <.0001; HR: 1.3: 95% CI: 1.2-1.5). Conclusions: This study did not show a strong correlation between plasma PAI-1 and serum CRP in patients with colorectal cancer. Serum CRP was found to be a Dukes independent prognostic variable in this patient cohort, and was found to identify a subgroup of curatively resected patients at risk for short survival.

Original language	English
Journal	Annals of Surgical Oncology
Volume	7
Issue number	8
Pages (from-to)	617-623
Number of pages	7
ISSN	1068-9265
DOIs	https://doi.org/10.1007/BF02725342
Publication status	Published - 1 Jan 2000

Keywords

Blood transfusion
C-reactive protein
Colorectal cancer
Plasminogen activator inhibitor-1
Prognosis
Survival

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02725342

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Nielsen, H. J., Christensen, I. J., Sørensen, S., Moesgaard, F., Brünner, N., Schulze, S., Thorup, J., Wille-Jørgensen, P., Bentzen, E., Banke, L., Froberg, D., Henriksen, F. W., Crone, P., Hesselfeldt, P., Hempel-Sparsø, B., Larsen, K. L., Asmussen, T., Heiner, J., Hansen, O. H., ... Packler, J. (2000). Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer. Annals of Surgical Oncology, 7(8), 617-623. https://doi.org/10.1007/BF02725342

Nielsen, HJ, Christensen, IJ, Sørensen, S, Moesgaard, F, Brünner, N, Schulze, S, Thorup, J, Wille-Jørgensen, P, Bentzen, E, Banke, L, Froberg, D, Henriksen, FW, Crone, P, Hesselfeldt, P, Hempel-Sparsø, B, Larsen, KL, Asmussen, T, Heiner, J, Hansen, OH, Flyger, H, Jess, P, Iversen, J, Andersen, JLC, Vennits, B, Hammer, JH, Fischer, A, Galatius, H, Naver, L, Teilum, D, Holbraad, L, Iversen, O, Nymark, J, Roikjær, O, Palm, L, Rasmussen, KC, Friis, J, Lanng, C, Ovesen, H, Jensen, NC, Hoffman, N, Larse, T & Packler, J 2000, 'Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer', Annals of Surgical Oncology, vol. 7, no. 8, pp. 617-623. https://doi.org/10.1007/BF02725342

@article{5a45ea71707c4034a1dd7e323654bcd8,

title = "Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer",

abstract = "Background: Preoperative plasma plasminogen activator inhibitor-1 (PAI-1) is a prognostic variable in patients with colorectal cancer. It has been suggested, however, that plasma PAI-1 is a nonspecific prognostic parameter similar to the acute-phase reactant C-reactive protein (CRP). In the present study we analyzed the association between plasma PAI-1 and serum CRP in patients scheduled for elective resection of colorectal cancer. In addition, the prognostic value of PAI-1 and CRP was studied in this patient cohort. Methods: PAI-1 and CRP were analyzed in citrated plasma and serum, respectively, obtained preoperatively from 594 patients. Patients who required preoperative blood transfusion received SAGM blood, in which soluble PAI-1 is not present. None of the patients received pre- or postoperative adjuvant chemotherapy, and all were followed in the outpatient clinic for at least 5 years or until death. The association of PAI-1 and CRP, respectively, with survival was tested using the median value of PAI-1 and the upper normal limit for CRP. Analyses were performed by inclusion of all patients, and in the subgroup of patients, who underwent curative resection. Results: The median follow-up period was 6.8 (5.4-7.9) years. The median value of plasma PAI-1 was 35.8 ng/ml, and values greater than 94 nmol/L identified patients with increased CRP levels. Comparison of the molecules showed that PAI-1 was weakly correlated with CRP (r = .26; P <.0001). Both molecules showed a Dukes independent distribution. In univariate survival analyses high levels of PAI-1 were found associated with poor prognosis and low levels with good prognosis (P = .02, HR: 1.3). Similarly, high levels of CRP were found associated with poor prognosis and low levels with good prognosis (P <.0001, HR: 1.9). In a multivariate statistical analysis including Dukes classification, gender, age, tumor location, perioperative blood transfusion, PAI-1 and CRP, plasma PAI-1 was a dependent prognostic variable, while serum CRP (P <.0001; HR: 1.4; 95% CI: 1.3-1.5) was found to be a Dukes independent prognostic variable. Similar analyses, excluding patients with Dukes, D disease showed serum CRP to be an independent prognostic variable (P <.0001; HR: 1.3: 95% CI: 1.2-1.5). Conclusions: This study did not show a strong correlation between plasma PAI-1 and serum CRP in patients with colorectal cancer. Serum CRP was found to be a Dukes independent prognostic variable in this patient cohort, and was found to identify a subgroup of curatively resected patients at risk for short survival.",

keywords = "Blood transfusion, C-reactive protein, Colorectal cancer, Plasminogen activator inhibitor-1, Prognosis, Survival",

author = "Nielsen, {Hans J{\o}rgen} and Christensen, {Ib Jarle} and Steen S{\o}rensen and Flemming Moesgaard and Nils Br{\"u}nner and Svend Schulze and Jens Thorup and Peer Wille-J{\o}rgensen and Erik Bentzen and Lars Banke and Dorthe Froberg and Henriksen, {Finn W.} and Poul Crone and Peter Hesselfeldt and Bo Hempel-Spars{\o} and Larsen, {Karen Lindorff} and Torsten Asmussen and J{\o}rgen Heiner and Hansen, {Ole Hart} and Henrik Flyger and Per Jess and J{\o}rgen Iversen and Andersen, {J{\o}rgen La Cour} and Bo Vennits and Hammer, {Janne H.} and Anders Fischer and Hanne Galatius and Lars Naver and Dorthe Teilum and Leif Holbraad and Ole Iversen and Jens Nymark and Ole Roikj{\ae}r and Leif Palm and Rasmussen, {Kirsten C.} and J{\o}rn Friis and Charlotte Lanng and Henrik Ovesen and Jensen, {Niels Chr} and Niels Hoffman and Torben Larse and J{\o}rgen Packler",

year = "2000",

month = jan,

day = "1",

doi = "10.1007/BF02725342",

language = "English",

volume = "7",

pages = "617--623",

journal = "Annals of Surgical Oncology",

issn = "1068-9265",

publisher = "Springer",

number = "8",

}

TY - JOUR

T1 - Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer

AU - Nielsen, Hans Jørgen

AU - Christensen, Ib Jarle

AU - Sørensen, Steen

AU - Moesgaard, Flemming

AU - Brünner, Nils

AU - Schulze, Svend

AU - Thorup, Jens

AU - Wille-Jørgensen, Peer

AU - Bentzen, Erik

AU - Banke, Lars

AU - Froberg, Dorthe

AU - Henriksen, Finn W.

AU - Crone, Poul

AU - Hesselfeldt, Peter

AU - Hempel-Sparsø, Bo

AU - Larsen, Karen Lindorff

AU - Asmussen, Torsten

AU - Heiner, Jørgen

AU - Hansen, Ole Hart

AU - Flyger, Henrik

AU - Jess, Per

AU - Iversen, Jørgen

AU - Andersen, Jørgen La Cour

AU - Vennits, Bo

AU - Hammer, Janne H.

AU - Fischer, Anders

AU - Galatius, Hanne

AU - Naver, Lars

AU - Teilum, Dorthe

AU - Holbraad, Leif

AU - Iversen, Ole

AU - Nymark, Jens

AU - Roikjær, Ole

AU - Palm, Leif

AU - Rasmussen, Kirsten C.

AU - Friis, Jørn

AU - Lanng, Charlotte

AU - Ovesen, Henrik

AU - Jensen, Niels Chr

AU - Hoffman, Niels

AU - Larse, Torben

AU - Packler, Jørgen

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Background: Preoperative plasma plasminogen activator inhibitor-1 (PAI-1) is a prognostic variable in patients with colorectal cancer. It has been suggested, however, that plasma PAI-1 is a nonspecific prognostic parameter similar to the acute-phase reactant C-reactive protein (CRP). In the present study we analyzed the association between plasma PAI-1 and serum CRP in patients scheduled for elective resection of colorectal cancer. In addition, the prognostic value of PAI-1 and CRP was studied in this patient cohort. Methods: PAI-1 and CRP were analyzed in citrated plasma and serum, respectively, obtained preoperatively from 594 patients. Patients who required preoperative blood transfusion received SAGM blood, in which soluble PAI-1 is not present. None of the patients received pre- or postoperative adjuvant chemotherapy, and all were followed in the outpatient clinic for at least 5 years or until death. The association of PAI-1 and CRP, respectively, with survival was tested using the median value of PAI-1 and the upper normal limit for CRP. Analyses were performed by inclusion of all patients, and in the subgroup of patients, who underwent curative resection. Results: The median follow-up period was 6.8 (5.4-7.9) years. The median value of plasma PAI-1 was 35.8 ng/ml, and values greater than 94 nmol/L identified patients with increased CRP levels. Comparison of the molecules showed that PAI-1 was weakly correlated with CRP (r = .26; P <.0001). Both molecules showed a Dukes independent distribution. In univariate survival analyses high levels of PAI-1 were found associated with poor prognosis and low levels with good prognosis (P = .02, HR: 1.3). Similarly, high levels of CRP were found associated with poor prognosis and low levels with good prognosis (P <.0001, HR: 1.9). In a multivariate statistical analysis including Dukes classification, gender, age, tumor location, perioperative blood transfusion, PAI-1 and CRP, plasma PAI-1 was a dependent prognostic variable, while serum CRP (P <.0001; HR: 1.4; 95% CI: 1.3-1.5) was found to be a Dukes independent prognostic variable. Similar analyses, excluding patients with Dukes, D disease showed serum CRP to be an independent prognostic variable (P <.0001; HR: 1.3: 95% CI: 1.2-1.5). Conclusions: This study did not show a strong correlation between plasma PAI-1 and serum CRP in patients with colorectal cancer. Serum CRP was found to be a Dukes independent prognostic variable in this patient cohort, and was found to identify a subgroup of curatively resected patients at risk for short survival.

AB - Background: Preoperative plasma plasminogen activator inhibitor-1 (PAI-1) is a prognostic variable in patients with colorectal cancer. It has been suggested, however, that plasma PAI-1 is a nonspecific prognostic parameter similar to the acute-phase reactant C-reactive protein (CRP). In the present study we analyzed the association between plasma PAI-1 and serum CRP in patients scheduled for elective resection of colorectal cancer. In addition, the prognostic value of PAI-1 and CRP was studied in this patient cohort. Methods: PAI-1 and CRP were analyzed in citrated plasma and serum, respectively, obtained preoperatively from 594 patients. Patients who required preoperative blood transfusion received SAGM blood, in which soluble PAI-1 is not present. None of the patients received pre- or postoperative adjuvant chemotherapy, and all were followed in the outpatient clinic for at least 5 years or until death. The association of PAI-1 and CRP, respectively, with survival was tested using the median value of PAI-1 and the upper normal limit for CRP. Analyses were performed by inclusion of all patients, and in the subgroup of patients, who underwent curative resection. Results: The median follow-up period was 6.8 (5.4-7.9) years. The median value of plasma PAI-1 was 35.8 ng/ml, and values greater than 94 nmol/L identified patients with increased CRP levels. Comparison of the molecules showed that PAI-1 was weakly correlated with CRP (r = .26; P <.0001). Both molecules showed a Dukes independent distribution. In univariate survival analyses high levels of PAI-1 were found associated with poor prognosis and low levels with good prognosis (P = .02, HR: 1.3). Similarly, high levels of CRP were found associated with poor prognosis and low levels with good prognosis (P <.0001, HR: 1.9). In a multivariate statistical analysis including Dukes classification, gender, age, tumor location, perioperative blood transfusion, PAI-1 and CRP, plasma PAI-1 was a dependent prognostic variable, while serum CRP (P <.0001; HR: 1.4; 95% CI: 1.3-1.5) was found to be a Dukes independent prognostic variable. Similar analyses, excluding patients with Dukes, D disease showed serum CRP to be an independent prognostic variable (P <.0001; HR: 1.3: 95% CI: 1.2-1.5). Conclusions: This study did not show a strong correlation between plasma PAI-1 and serum CRP in patients with colorectal cancer. Serum CRP was found to be a Dukes independent prognostic variable in this patient cohort, and was found to identify a subgroup of curatively resected patients at risk for short survival.

KW - Blood transfusion

KW - C-reactive protein

KW - Colorectal cancer

KW - Plasminogen activator inhibitor-1

KW - Prognosis

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=0033835299&partnerID=8YFLogxK

U2 - 10.1007/BF02725342

DO - 10.1007/BF02725342

M3 - Journal article

C2 - 11005561

AN - SCOPUS:0033835299

SN - 1068-9265

VL - 7

SP - 617

EP - 623

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

IS - 8

ER -

Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer

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