Prenatal and Postnatal Medical Conditions and the Risk of Brain Tumors in Children and Adolescents: An International Multicenter Case-Control Study

Giorgio Tettamanti; Xiaochen Shu; Maral Adel Fahmideh; Joachim Schüz; Martin Röösli; Tore Tynes; Michael Grotzer; Christoffer Johansen; Lars Klaeboe; Claudia E Kuehni; Birgitta Lannering; Lisbeth S Schmidt; Danielle Vienneau; Maria Feychting

doi:10.1158/1055-9965.epi-16-0451

Prenatal and Postnatal Medical Conditions and the Risk of Brain Tumors in Children and Adolescents: An International Multicenter Case-Control Study

Giorgio Tettamanti, Xiaochen Shu, Maral Adel Fahmideh, Joachim Schüz, Martin Röösli, Tore Tynes, Michael Grotzer, Christoffer Johansen, Lars Klaeboe, Claudia E Kuehni, Birgitta Lannering, Lisbeth S Schmidt, Danielle Vienneau, Maria Feychting

Department of Clinical Medicine

4 Citations (Scopus)

Abstract

Background: Previous studies have evaluated the effect of medical diagnostic radiation on brain tumors. Recent cohort studies have reported an increased risk associated with exposure to head CT scans. Methods: Information regarding medical conditions, including prenatal and postnatal exposure to medical diagnostic radiation, was obtained from CEFALO, a multicenter case-control study performed in Denmark, Norway, Sweden, and Switzerland through face-To-face interview. Eligible cases of childhood and adolescent brain tumors (CABT) were ages 7 to 19 years, diagnosed between January 1, 2004 and August 31, 2008, and living in the participating countries (n =352). The cases were matched by age, sex, and region to 646 populationbased controls. Results: Prenatal exposure to medical diagnostic radiation and postnatal exposure to X-rays were not associated with CABTs. A higher risk estimate of CABTs, although not statistically significant, was found for exposure to head CT scan (OR, 1.86; 95% confidence interval, 0.82-4.22). The associations with head injury, febrile seizure, fever in the first 12 weeks, and general anesthesia were close to unity. Conclusions: Prenatal or postnatal medical conditions, including medical diagnostic radiation, were not associated with CABTs. On the basis of small numbers of exposed children, we observed a nonsignificant increased risk for CT scans of the head. Impact:Wehave presented additional evidence, suggesting that exposure to head CT scan may be associated with the occurrence of CABTs.

Original language	English
Journal	Cancer Epidemiology, Biomarkers & Prevention
Volume	26
Issue number	1
Pages (from-to)	110-115
ISSN	1055-9965
DOIs	https://doi.org/10.1158/1055-9965.epi-16-0451
Publication status	Published - Jan 2017

Keywords

Adolescent
Brain Neoplasms/epidemiology
Case-Control Studies
Child
Confidence Intervals
Denmark/epidemiology
Female
Humans
Internationality
Magnetic Resonance Imaging/adverse effects
Male
Norway/epidemiology
Odds Ratio
Positron-Emission Tomography/adverse effects
Postnatal Care/methods
Pregnancy
Prenatal Care/methods
Prenatal Exposure Delayed Effects/epidemiology
Radiation Dosage
Radiation Exposure/adverse effects
Sweden/epidemiology
Switzerland/epidemiology
Tomography, X-Ray Computed/adverse effects

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/1055-9965.epi-16-0451

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https://cebp.aacrjournals.org/content/cebp/26/1/110.full.pdf

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Tettamanti, G., Shu, X., Adel Fahmideh, M., Schüz, J., Röösli, M., Tynes, T., Grotzer, M., Johansen, C., Klaeboe, L., Kuehni, C. E., Lannering, B., Schmidt, L. S., Vienneau, D., & Feychting, M. (2017). Prenatal and Postnatal Medical Conditions and the Risk of Brain Tumors in Children and Adolescents: An International Multicenter Case-Control Study. Cancer Epidemiology, Biomarkers & Prevention, 26(1), 110-115. https://doi.org/10.1158/1055-9965.epi-16-0451

Prenatal and Postnatal Medical Conditions and the Risk of Brain Tumors in Children and Adolescents : An International Multicenter Case-Control Study. / Tettamanti, Giorgio; Shu, Xiaochen; Adel Fahmideh, Maral et al.

In: Cancer Epidemiology, Biomarkers & Prevention, Vol. 26, No. 1, 01.2017, p. 110-115.

Research output: Contribution to journal › Journal article › Research › peer-review

Tettamanti, G, Shu, X, Adel Fahmideh, M, Schüz, J, Röösli, M, Tynes, T, Grotzer, M, Johansen, C, Klaeboe, L, Kuehni, CE, Lannering, B, Schmidt, LS, Vienneau, D & Feychting, M 2017, 'Prenatal and Postnatal Medical Conditions and the Risk of Brain Tumors in Children and Adolescents: An International Multicenter Case-Control Study', Cancer Epidemiology, Biomarkers & Prevention, vol. 26, no. 1, pp. 110-115. https://doi.org/10.1158/1055-9965.epi-16-0451

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abstract = "Background: Previous studies have evaluated the effect of medical diagnostic radiation on brain tumors. Recent cohort studies have reported an increased risk associated with exposure to head CT scans. Methods: Information regarding medical conditions, including prenatal and postnatal exposure to medical diagnostic radiation, was obtained from CEFALO, a multicenter case-control study performed in Denmark, Norway, Sweden, and Switzerland through face-To-face interview. Eligible cases of childhood and adolescent brain tumors (CABT) were ages 7 to 19 years, diagnosed between January 1, 2004 and August 31, 2008, and living in the participating countries (n =352). The cases were matched by age, sex, and region to 646 populationbased controls. Results: Prenatal exposure to medical diagnostic radiation and postnatal exposure to X-rays were not associated with CABTs. A higher risk estimate of CABTs, although not statistically significant, was found for exposure to head CT scan (OR, 1.86; 95% confidence interval, 0.82-4.22). The associations with head injury, febrile seizure, fever in the first 12 weeks, and general anesthesia were close to unity. Conclusions: Prenatal or postnatal medical conditions, including medical diagnostic radiation, were not associated with CABTs. On the basis of small numbers of exposed children, we observed a nonsignificant increased risk for CT scans of the head. Impact:Wehave presented additional evidence, suggesting that exposure to head CT scan may be associated with the occurrence of CABTs.",

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AU - Adel Fahmideh, Maral

AU - Schüz, Joachim

AU - Röösli, Martin

AU - Tynes, Tore

AU - Grotzer, Michael

AU - Johansen, Christoffer

AU - Klaeboe, Lars

AU - Kuehni, Claudia E

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KW - Switzerland/epidemiology

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Prenatal and Postnatal Medical Conditions and the Risk of Brain Tumors in Children and Adolescents: An International Multicenter Case-Control Study

Abstract

Keywords

UN SDGs

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