TY - JOUR
T1 - Pregnancy-induced increase in circulating IGF-I is associated with progression of diabetic retinopathy in women with type 1 diabetes
AU - Nielsen, Lene Ringholm
AU - Vestgaard, Marianne
AU - Laugesen, Caroline S
AU - Juul, Anders
AU - Damm, Peter
AU - Mathiesen, Elisabeth R
AU - Vestgaard, Marianne
AU - Laugesen, C.S.
N1 - Copyright © 2010 Growth Hormone Research Society. Published by Elsevier Ltd. All rights reserved.
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Objective: To evaluate the influence of Insulin-like Growth factor-I (IGF-I) and Placental Growth Hormone (GH) on progression of diabetic retinopathy during pregnancy in women with type 1 diabetes. Design: Observational study of 88 consecutive pregnant women with type 1 diabetes for median 16.5years (range 1-36) and HbA1c 6.6% (5.2-10.5) in early pregnancy. At 8, 14, 21, 27 and 33weeks blood samples were drawn for measurement of IGF-I, placental GH and Hemoglobin A1c (HbA1c) and blood pressure was recorded. Fundus photography was performed at 8 and 27weeks. Diabetic retinopathy was classified in five stages. Progression was defined as deterioration of at least one stage of diabetic retinopathy and/or development of macular edema on at least one eye. Results: Placental GH and IGF-I levels increased throughout pregnancy and new onset or progression of diabetic retinopathy occurred in 22 (25%). A steeper increase in women with progression of diabetic retinopathy resulted in higher IGF-I levels at 27weeks (p=0.01) and 16% higher IGF-I levels throughout pregnancy (p=0.02) compared with women without progression while similar levels of placental GH (p=0.58) and HbA1c (p=0.85) were observed throughout pregnancy. In a multivariate logistic regression analysis, progression of diabetic retinopathy was associated with higher IGF-I levels at 33weeks (odds ratio 2.0 [95% confidence interval 1.1-3.6], p=0.02) and higher systolic blood pressure at 8weeks (1.9 [1.1-3.2], p=0.02) independent of placental GH and HbA1c levels. Conclusions: Pregnancy-induced increase in IGF-I levels is associated with progression of diabetic retinopathy in women with type 1 diabetes.
AB - Objective: To evaluate the influence of Insulin-like Growth factor-I (IGF-I) and Placental Growth Hormone (GH) on progression of diabetic retinopathy during pregnancy in women with type 1 diabetes. Design: Observational study of 88 consecutive pregnant women with type 1 diabetes for median 16.5years (range 1-36) and HbA1c 6.6% (5.2-10.5) in early pregnancy. At 8, 14, 21, 27 and 33weeks blood samples were drawn for measurement of IGF-I, placental GH and Hemoglobin A1c (HbA1c) and blood pressure was recorded. Fundus photography was performed at 8 and 27weeks. Diabetic retinopathy was classified in five stages. Progression was defined as deterioration of at least one stage of diabetic retinopathy and/or development of macular edema on at least one eye. Results: Placental GH and IGF-I levels increased throughout pregnancy and new onset or progression of diabetic retinopathy occurred in 22 (25%). A steeper increase in women with progression of diabetic retinopathy resulted in higher IGF-I levels at 27weeks (p=0.01) and 16% higher IGF-I levels throughout pregnancy (p=0.02) compared with women without progression while similar levels of placental GH (p=0.58) and HbA1c (p=0.85) were observed throughout pregnancy. In a multivariate logistic regression analysis, progression of diabetic retinopathy was associated with higher IGF-I levels at 33weeks (odds ratio 2.0 [95% confidence interval 1.1-3.6], p=0.02) and higher systolic blood pressure at 8weeks (1.9 [1.1-3.2], p=0.02) independent of placental GH and HbA1c levels. Conclusions: Pregnancy-induced increase in IGF-I levels is associated with progression of diabetic retinopathy in women with type 1 diabetes.
U2 - 10.1016/j.ghir.2010.12.001
DO - 10.1016/j.ghir.2010.12.001
M3 - Journal article
C2 - 21212010
SN - 1096-6374
VL - 21
SP - 25
EP - 30
JO - Growth Hormone & I G F Research
JF - Growth Hormone & I G F Research
IS - 1
ER -
