TY - JOUR
T1 - Prefrontal cortex and hippocampus in behavioural flexibility and posttraumatic functional recovery
T2 - Reversal learning and set-shifting in rats
AU - Rytter, Hana Malá
AU - Andersen, Lykke Grønbech
AU - Christensen, Rie Friis
AU - Felbinger, Anita
AU - Hagstrøm, Julie
AU - Meder, David
AU - Pearce, Hadley
AU - Mogensen, Jesper
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Within one experiment and one T-maze, we examined the consequences of (i) bilateral lesions of the anteromedial prefrontal cortex (PFC), (ii) bilateral transections of the fimbria-fornix (FF), or (iii) combined lesions of both PFC and FF (COMB) on rats' ability to perform reversal or set-shifting. Postoperatively, the animals were trained to perform a spatial discrimination go-right task. This was followed by (1) a spatial reversal go-left task (reversal learning), or (2) a visual pattern discrimination task (set-shift). Neither single (PFC or FF) lesion nor combined (COMB) lesions affected the animals' ability to acquire the original spatial discrimination task. Regarding the reversal learning, the performance of the PFC and the FF groups was not significantly different from that of the sham operated control animals (Sham). In contrast, animals with combined lesion of both structures were impaired on both error rate and acquisition speed relative to all other groups. Regarding the set-shifting, all lesioned groups were impaired relative to the Sham group both regarding the error rate and the acquisition speed. There was, however, no difference in the degree of impairment between the lesioned groups. We conclude that both the PFC and the hippocampus contributed to the mediation of the reversal learning and set-shifting. During functional recovery of reversal learning, these two structures exhibited a mutual dependency, whilst the functional recovery of set-shifting was mediated by a substrate outside these two structures.
AB - Within one experiment and one T-maze, we examined the consequences of (i) bilateral lesions of the anteromedial prefrontal cortex (PFC), (ii) bilateral transections of the fimbria-fornix (FF), or (iii) combined lesions of both PFC and FF (COMB) on rats' ability to perform reversal or set-shifting. Postoperatively, the animals were trained to perform a spatial discrimination go-right task. This was followed by (1) a spatial reversal go-left task (reversal learning), or (2) a visual pattern discrimination task (set-shift). Neither single (PFC or FF) lesion nor combined (COMB) lesions affected the animals' ability to acquire the original spatial discrimination task. Regarding the reversal learning, the performance of the PFC and the FF groups was not significantly different from that of the sham operated control animals (Sham). In contrast, animals with combined lesion of both structures were impaired on both error rate and acquisition speed relative to all other groups. Regarding the set-shifting, all lesioned groups were impaired relative to the Sham group both regarding the error rate and the acquisition speed. There was, however, no difference in the degree of impairment between the lesioned groups. We conclude that both the PFC and the hippocampus contributed to the mediation of the reversal learning and set-shifting. During functional recovery of reversal learning, these two structures exhibited a mutual dependency, whilst the functional recovery of set-shifting was mediated by a substrate outside these two structures.
KW - Faculty of Social Sciences
KW - Prefrontal cortex
KW - Hippocampus
KW - Hjerneskade
KW - Plasticitet
KW - Funktionel genopretning
KW - REF-modellen
KW - Animal Model
KW - Dyremodel
KW - Cognition
KW - cognitive rehabilitation
KW - Cognitive flexibility
KW - Reversal learning
KW - set-shifting
KW - Strategy
KW - adfærds strategi
U2 - 10.1016/j.brainresbull.2015.05.006
DO - 10.1016/j.brainresbull.2015.05.006
M3 - Journal article
C2 - 26033702
SN - 0361-9230
VL - 116
SP - 34
EP - 44
JO - Brain Research Bulletin
JF - Brain Research Bulletin
ER -