Predictors of recovery in first episode psychosis: The OPUS cohort at 10 year follow-up

Stephen Austin; Ole Mors; Rikke Gry Secher; Carsten R Hjorthøj; Nikolai Albert; Mette Bertelsen; Heidi Dorthe Jensen; Pia Jeppesen; Lone Petersen; Lasse Randers; Anne Thorup; Merete Nordentoft

doi:10.1016/j.schres.2013.07.031

Predictors of recovery in first episode psychosis: The OPUS cohort at 10 year follow-up

Stephen Austin, Ole Mors, Rikke Gry Secher, Carsten R Hjorthøj, Nikolai Albert, Mette Bertelsen, Heidi Dorthe Jensen, Pia Jeppesen, Lone Petersen, Lasse Randers, Anne Thorup, Merete Nordentoft

Department of Clinical Medicine

102 Citations (Scopus)

Abstract

Background: Recovery, the optimal goal in treatment, is the attainment of both symptomatic and functional remission over a sustained period of time. Identification of factors that promote recovery can help develop interventions that facilitate good outcomes for people with first episode psychosis. Aim: To examine long-term outcomes within a cohort of people with first episode psychosis in relation to symptom remission, functioning and recovery, 10. years after diagnosis. Method: The study had a prospective design. Participants from the OPUS trial (1998-2000) (n = 496) completed a series of interviews and questionnaires to measure current levels of psychopathology and social/vocational functioning, ten years after diagnosis. Predictors of recovery were identified using socio-demographic and clinical characteristics collected at baseline. Results: A total of 304 participants were interviewed, giving a follow-up rate of 61%. A total of 42 people (14%) met the criteria for symptomatic and psychosocial recovery at 10. years. A multivariable binary logistic regression analysis indicated that baseline predictors accounted for 22% of the variance of full recovery. Lower severity of negative symptoms at baseline (Odds Ratio (OR) 0.53, 95% confidence interval CI 0.36-0.78, p < 0.001) and earlier age of diagnosis (OR 0.92, 95% CI 0.86-0.99, p < 0.05) predicted better rates of recovery at 10. years. Conclusion: Results of this study indicated that negative symptoms could play a central role in the process of recovery from schizophrenia. A challenge for clinicians and researchers is to understand the mechanisms behind negative symptoms and develop interventions that can prevent or ameliorate these symptoms in order to promote recovery.

Original language	English
Journal	Schizophrenia Research
Volume	150
Issue number	1
Pages (from-to)	163-168
Number of pages	6
ISSN	0920-9964
DOIs	https://doi.org/10.1016/j.schres.2013.07.031
Publication status	Published - Oct 2013

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10.1016/j.schres.2013.07.031

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@article{bc02353b4c5e46af903aff90e2d7afb1,

title = "Predictors of recovery in first episode psychosis: The OPUS cohort at 10 year follow-up",

abstract = "Background: Recovery, the optimal goal in treatment, is the attainment of both symptomatic and functional remission over a sustained period of time. Identification of factors that promote recovery can help develop interventions that facilitate good outcomes for people with first episode psychosis. Aim: To examine long-term outcomes within a cohort of people with first episode psychosis in relation to symptom remission, functioning and recovery, 10. years after diagnosis. Method: The study had a prospective design. Participants from the OPUS trial (1998-2000) (n = 496) completed a series of interviews and questionnaires to measure current levels of psychopathology and social/vocational functioning, ten years after diagnosis. Predictors of recovery were identified using socio-demographic and clinical characteristics collected at baseline. Results: A total of 304 participants were interviewed, giving a follow-up rate of 61%. A total of 42 people (14%) met the criteria for symptomatic and psychosocial recovery at 10. years. A multivariable binary logistic regression analysis indicated that baseline predictors accounted for 22% of the variance of full recovery. Lower severity of negative symptoms at baseline (Odds Ratio (OR) 0.53, 95% confidence interval CI 0.36-0.78, p < 0.001) and earlier age of diagnosis (OR 0.92, 95% CI 0.86-0.99, p < 0.05) predicted better rates of recovery at 10. years. Conclusion: Results of this study indicated that negative symptoms could play a central role in the process of recovery from schizophrenia. A challenge for clinicians and researchers is to understand the mechanisms behind negative symptoms and develop interventions that can prevent or ameliorate these symptoms in order to promote recovery.",

author = "Stephen Austin and Ole Mors and Secher, {Rikke Gry} and Hjorth{\o}j, {Carsten R} and Nikolai Albert and Mette Bertelsen and Jensen, {Heidi Dorthe} and Pia Jeppesen and Lone Petersen and Lasse Randers and Anne Thorup and Merete Nordentoft",

year = "2013",

month = oct,

doi = "10.1016/j.schres.2013.07.031",

language = "English",

volume = "150",

pages = "163--168",

journal = "Schizophrenia Research",

issn = "0920-9964",

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T1 - Predictors of recovery in first episode psychosis

T2 - The OPUS cohort at 10 year follow-up

AU - Austin, Stephen

AU - Mors, Ole

AU - Secher, Rikke Gry

AU - Hjorthøj, Carsten R

AU - Albert, Nikolai

AU - Bertelsen, Mette

AU - Jensen, Heidi Dorthe

AU - Jeppesen, Pia

AU - Petersen, Lone

AU - Randers, Lasse

AU - Thorup, Anne

AU - Nordentoft, Merete

PY - 2013/10

Y1 - 2013/10

N2 - Background: Recovery, the optimal goal in treatment, is the attainment of both symptomatic and functional remission over a sustained period of time. Identification of factors that promote recovery can help develop interventions that facilitate good outcomes for people with first episode psychosis. Aim: To examine long-term outcomes within a cohort of people with first episode psychosis in relation to symptom remission, functioning and recovery, 10. years after diagnosis. Method: The study had a prospective design. Participants from the OPUS trial (1998-2000) (n = 496) completed a series of interviews and questionnaires to measure current levels of psychopathology and social/vocational functioning, ten years after diagnosis. Predictors of recovery were identified using socio-demographic and clinical characteristics collected at baseline. Results: A total of 304 participants were interviewed, giving a follow-up rate of 61%. A total of 42 people (14%) met the criteria for symptomatic and psychosocial recovery at 10. years. A multivariable binary logistic regression analysis indicated that baseline predictors accounted for 22% of the variance of full recovery. Lower severity of negative symptoms at baseline (Odds Ratio (OR) 0.53, 95% confidence interval CI 0.36-0.78, p < 0.001) and earlier age of diagnosis (OR 0.92, 95% CI 0.86-0.99, p < 0.05) predicted better rates of recovery at 10. years. Conclusion: Results of this study indicated that negative symptoms could play a central role in the process of recovery from schizophrenia. A challenge for clinicians and researchers is to understand the mechanisms behind negative symptoms and develop interventions that can prevent or ameliorate these symptoms in order to promote recovery.

AB - Background: Recovery, the optimal goal in treatment, is the attainment of both symptomatic and functional remission over a sustained period of time. Identification of factors that promote recovery can help develop interventions that facilitate good outcomes for people with first episode psychosis. Aim: To examine long-term outcomes within a cohort of people with first episode psychosis in relation to symptom remission, functioning and recovery, 10. years after diagnosis. Method: The study had a prospective design. Participants from the OPUS trial (1998-2000) (n = 496) completed a series of interviews and questionnaires to measure current levels of psychopathology and social/vocational functioning, ten years after diagnosis. Predictors of recovery were identified using socio-demographic and clinical characteristics collected at baseline. Results: A total of 304 participants were interviewed, giving a follow-up rate of 61%. A total of 42 people (14%) met the criteria for symptomatic and psychosocial recovery at 10. years. A multivariable binary logistic regression analysis indicated that baseline predictors accounted for 22% of the variance of full recovery. Lower severity of negative symptoms at baseline (Odds Ratio (OR) 0.53, 95% confidence interval CI 0.36-0.78, p < 0.001) and earlier age of diagnosis (OR 0.92, 95% CI 0.86-0.99, p < 0.05) predicted better rates of recovery at 10. years. Conclusion: Results of this study indicated that negative symptoms could play a central role in the process of recovery from schizophrenia. A challenge for clinicians and researchers is to understand the mechanisms behind negative symptoms and develop interventions that can prevent or ameliorate these symptoms in order to promote recovery.

U2 - 10.1016/j.schres.2013.07.031

DO - 10.1016/j.schres.2013.07.031

M3 - Journal article

C2 - 23932664

SN - 0920-9964

VL - 150

SP - 163

EP - 168

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1

ER -

Predictors of recovery in first episode psychosis: The OPUS cohort at 10 year follow-up

Abstract

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