Predictors of hemoglobin in Danish blood donors: results from the Danish Blood Donor Study

TY - JOUR

T1 - Predictors of hemoglobin in Danish blood donors

T2 - results from the Danish Blood Donor Study

AU - Kotze, Sebastian Ranzi

AU - Pedersen, Ole B

AU - Petersen, Mikkel S

AU - Sørensen, Erik

AU - Thørner, Lise Wegner

AU - Sørensen, Cecilie J

AU - Rigas, Andreas S

AU - Hjalgrim, Henrik

AU - Rostgaard, Klaus

AU - Ullum, Henrik

AU - Erikstrup, Christian

N1 - © 2015 AABB.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - BACKGROUND: It is well known that blood donors are at increased risk of iron deficiency and subsequent development of iron deficiency anemia. We aimed to investigate the effect of factors influencing hemoglobin (Hb) levels. STUDY DESIGN AND METHODS: Initiated in 2010, the Danish Blood Donor Study is a population-based study and biobank. We performed multivariable linear regression analysis to assess the effects of donation activity, physiologic and lifestyle factors, and diet on Hb levels among 15,197 donors. We also performed multivariable logistic regression to evaluate the effects of these factors on the risk of having low Hb (defined as Hb below the 10th percentile among men and women, respectively) and of a decrease in Hb greater than 0.5 mmol/L (0.8 g/dL) between successive donations. All analyses were performed stratified for sex and smoking status. We also tested a previously used model for the prediction of Hb. RESULTS: The strongest predictors of Hb and risk of low Hb were low ferritin (<15 ng/mL) and current use of iron supplementation (yes/no). No dietary factors were found to be consistently significant in multivariable models predicting Hb levels, risk of having low Hb, or risk of a decrease in Hb greater than 0.5 mmol/L. We found similar effects to previous studies of factors in the predictive model, with little additional effect of including smoking status and ferritin. CONCLUSIONS: As ferritin was the strongest predictor of Hb, this study supports the implementation of regular ferritin measurement as a method of risk assessment among blood donors.

AB - BACKGROUND: It is well known that blood donors are at increased risk of iron deficiency and subsequent development of iron deficiency anemia. We aimed to investigate the effect of factors influencing hemoglobin (Hb) levels. STUDY DESIGN AND METHODS: Initiated in 2010, the Danish Blood Donor Study is a population-based study and biobank. We performed multivariable linear regression analysis to assess the effects of donation activity, physiologic and lifestyle factors, and diet on Hb levels among 15,197 donors. We also performed multivariable logistic regression to evaluate the effects of these factors on the risk of having low Hb (defined as Hb below the 10th percentile among men and women, respectively) and of a decrease in Hb greater than 0.5 mmol/L (0.8 g/dL) between successive donations. All analyses were performed stratified for sex and smoking status. We also tested a previously used model for the prediction of Hb. RESULTS: The strongest predictors of Hb and risk of low Hb were low ferritin (<15 ng/mL) and current use of iron supplementation (yes/no). No dietary factors were found to be consistently significant in multivariable models predicting Hb levels, risk of having low Hb, or risk of a decrease in Hb greater than 0.5 mmol/L. We found similar effects to previous studies of factors in the predictive model, with little additional effect of including smoking status and ferritin. CONCLUSIONS: As ferritin was the strongest predictor of Hb, this study supports the implementation of regular ferritin measurement as a method of risk assessment among blood donors.

KW - Adolescent

KW - Adult

KW - Aged

KW - Anemia, Iron-Deficiency

KW - Blood Donors

KW - Body Mass Index

KW - Cohort Studies

KW - Contraceptives, Oral

KW - Denmark

KW - Diet

KW - Drug Utilization

KW - Female

KW - Ferritins

KW - Hemoglobins

KW - Humans

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - ROC Curve

KW - Reproductive History

KW - Risk Factors

KW - Sex Characteristics

KW - Smoking

KW - Surveys and Questionnaires

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/trf.13011

DO - 10.1111/trf.13011

M3 - Journal article

C2 - 25647099

SN - 0041-1132

VL - 55

SP - 1303

EP - 1311

JO - Transfusion

JF - Transfusion

IS - 6

ER -