Predictive value of natriuretic peptides in dogs with mitral valve disease

Inge Tarnow; Lisbeth Høier Olsen; Clarence Kvart; Katja Hoglund; Sophia Gry Moesgaard; Thea Sigbrit Kamstrup; Henrik Duelund Pedersen; Jens Häggström

doi:10.1016/j.tvjl.2007.12.026

Predictive value of natriuretic peptides in dogs with mitral valve disease

Inge Tarnow, Lisbeth Høier Olsen, Clarence Kvart, Katja Hoglund, Sophia Gry Moesgaard, Thea Sigbrit Kamstrup, Henrik Duelund Pedersen, Jens Häggström

62 Citations (Scopus)

Abstract

Natriuretic peptides are useful in diagnosing heart failure in dogs. However, their usefulness in detecting early stages of myxomatous mitral valve disease (MMVD) has been debated. This study evaluated N-terminal (NT) fragment pro-atrial natriuretic peptide (NT-proANP) and NT-pro-brain natriuretic peptide (NT-proBNP) in 39 Cavalier King Charles Spaniels (CKCS) with pre-clinical mitral valve regurgitation (MR), sixteen dogs with clinical signs of heart failure (HF) and thirteen healthy control dogs. Twenty seven CKCS and ten control dogs were re-examined 4 years after the initial examination and the status of the dogs 5 years after the initial examination was determined by telephone calls to the owner. All dogs were evaluated by clinical examination and echocardiography. CKCS with severe MR had higher NT-proANP and NT-proBNP compared to controls and CKCS with less severe MR. Dogs with clinical signs of HF had markedly elevated NT-proANP and NT-proBNP. Plasma concentrations of the natriuretic peptides measured at re-examination could predict progression in regurgitant jet size.

Original language	English
Journal	Veterinary Journal
Volume	180
Issue number	2
Pages (from-to)	195-201
Number of pages	7
ISSN	1090-0233
DOIs	https://doi.org/10.1016/j.tvjl.2007.12.026
Publication status	Published - 2009

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title = "Predictive value of natriuretic peptides in dogs with mitral valve disease",

abstract = "Natriuretic peptides are useful in diagnosing heart failure in dogs. However, their usefulness in detecting early stages of myxomatous mitral valve disease (MMVD) has been debated. This study evaluated N-terminal (NT) fragment pro-atrial natriuretic peptide (NT-proANP) and NT-pro-brain natriuretic peptide (NT-proBNP) in 39 Cavalier King Charles Spaniels (CKCS) with pre-clinical mitral valve regurgitation (MR), sixteen dogs with clinical signs of heart failure (HF) and thirteen healthy control dogs. Twenty seven CKCS and ten control dogs were re-examined 4 years after the initial examination and the status of the dogs 5 years after the initial examination was determined by telephone calls to the owner. All dogs were evaluated by clinical examination and echocardiography. CKCS with severe MR had higher NT-proANP and NT-proBNP compared to controls and CKCS with less severe MR. Dogs with clinical signs of HF had markedly elevated NT-proANP and NT-proBNP. Plasma concentrations of the natriuretic peptides measured at re-examination could predict progression in regurgitant jet size.",

author = "Inge Tarnow and Olsen, {Lisbeth H{\o}ier} and Clarence Kvart and Katja Hoglund and Moesgaard, {Sophia Gry} and Kamstrup, {Thea Sigbrit} and Pedersen, {Henrik Duelund} and Jens H{\"a}ggstr{\"o}m",

year = "2009",

doi = "10.1016/j.tvjl.2007.12.026",

language = "English",

volume = "180",

pages = "195--201",

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T1 - Predictive value of natriuretic peptides in dogs with mitral valve disease

AU - Tarnow, Inge

AU - Olsen, Lisbeth Høier

AU - Kvart, Clarence

AU - Hoglund, Katja

AU - Moesgaard, Sophia Gry

AU - Kamstrup, Thea Sigbrit

AU - Pedersen, Henrik Duelund

AU - Häggström, Jens

PY - 2009

Y1 - 2009

N2 - Natriuretic peptides are useful in diagnosing heart failure in dogs. However, their usefulness in detecting early stages of myxomatous mitral valve disease (MMVD) has been debated. This study evaluated N-terminal (NT) fragment pro-atrial natriuretic peptide (NT-proANP) and NT-pro-brain natriuretic peptide (NT-proBNP) in 39 Cavalier King Charles Spaniels (CKCS) with pre-clinical mitral valve regurgitation (MR), sixteen dogs with clinical signs of heart failure (HF) and thirteen healthy control dogs. Twenty seven CKCS and ten control dogs were re-examined 4 years after the initial examination and the status of the dogs 5 years after the initial examination was determined by telephone calls to the owner. All dogs were evaluated by clinical examination and echocardiography. CKCS with severe MR had higher NT-proANP and NT-proBNP compared to controls and CKCS with less severe MR. Dogs with clinical signs of HF had markedly elevated NT-proANP and NT-proBNP. Plasma concentrations of the natriuretic peptides measured at re-examination could predict progression in regurgitant jet size.

AB - Natriuretic peptides are useful in diagnosing heart failure in dogs. However, their usefulness in detecting early stages of myxomatous mitral valve disease (MMVD) has been debated. This study evaluated N-terminal (NT) fragment pro-atrial natriuretic peptide (NT-proANP) and NT-pro-brain natriuretic peptide (NT-proBNP) in 39 Cavalier King Charles Spaniels (CKCS) with pre-clinical mitral valve regurgitation (MR), sixteen dogs with clinical signs of heart failure (HF) and thirteen healthy control dogs. Twenty seven CKCS and ten control dogs were re-examined 4 years after the initial examination and the status of the dogs 5 years after the initial examination was determined by telephone calls to the owner. All dogs were evaluated by clinical examination and echocardiography. CKCS with severe MR had higher NT-proANP and NT-proBNP compared to controls and CKCS with less severe MR. Dogs with clinical signs of HF had markedly elevated NT-proANP and NT-proBNP. Plasma concentrations of the natriuretic peptides measured at re-examination could predict progression in regurgitant jet size.

U2 - 10.1016/j.tvjl.2007.12.026

DO - 10.1016/j.tvjl.2007.12.026

M3 - Journal article

C2 - 18675567

SN - 1090-0233

VL - 180

SP - 195

EP - 201

JO - Veterinary Journal

JF - Veterinary Journal

IS - 2

ER -

Predictive value of natriuretic peptides in dogs with mitral valve disease

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