Prediction of dementia by hippocampal shape analysis

Hakim C. Achterberg; Fedde van der Lijn; Tom den Heijer; Aad van der Lugt; Monique M. B. Breteler; Wiro J. Niessen; Marleen de Bruijne

doi:10.1007/978-3-642-15948-0_6

Prediction of dementia by hippocampal shape analysis

Hakim C. Achterberg, Fedde van der Lijn, Tom den Heijer, Aad van der Lugt, Monique M. B. Breteler, Wiro J. Niessen, Marleen de Bruijne

Department of Computer Science

7 Citations (Scopus)

Abstract

This work investigates the possibility of predicting future onset of dementia in subjects who are cognitively normal, using hippocampal shape and volume information extracted from MRI scans. A group of 47 subjects who were non-demented normal at the time of the MRI acquisition, but were diagnosed with dementia during a 9 year follow-up period, was selected from a large population based cohort study. 47 Age and gender matched subjects who stayed cognitively intact were selected from the same cohort study as a control group. The hippocampi were automatically segmented and all segmentations were inspected and, if necessary, manually corrected by a trained observer. From this data a statistical model of hippocampal shape was constructed, using an entropy-based particle system. This shape model provided the input for a Support Vector Machine classifier to predict dementia. Cross validation experiments showed that shape information can predict future onset of dementia in this dataset with an accuracy of 70%. By incorporating both shape and volume information into the classifier, the accuracy increased to 74%.

Original language	English
Title of host publication	Machine Learning in Medical Imaging : First International Workshop, MLMI 2010, Held in Conjunction with MICCAI 2010, Beijing, China, September 20, 2010. Proceedings
Editors	Fei Wang, Pingkun Yan, Kenji Suzuki, Dinggang Shen
Number of pages	8
Publisher	Springer
Publication date	2010
Pages	42-49
ISBN (Print)	978-3-642-15947-3
ISBN (Electronic)	978-3-642-15948-0
DOIs	https://doi.org/10.1007/978-3-642-15948-0_6
Publication status	Published - 2010
Event	1st International Workshop on Machine Learning in Medical Imaging - Beijing, China Duration: 20 Sept 2010 → 20 Sept 2010 Conference number: 1

Conference

Conference	1st International Workshop on Machine Learning in Medical Imaging
Number	1
Country/Territory	China
City	Beijing
Period	20/09/2010 → 20/09/2010

Series	Lecture notes in computer science
Volume	6357
ISSN	0302-9743

Access to Document

10.1007/978-3-642-15948-0_6

Cite this

Achterberg, H. C., van der Lijn, F., den Heijer, T., van der Lugt, A., Breteler, M. M. B., Niessen, W. J., & de Bruijne, M. (2010). Prediction of dementia by hippocampal shape analysis. In F. Wang, P. Yan, K. Suzuki, & D. Shen (Eds.), Machine Learning in Medical Imaging: First International Workshop, MLMI 2010, Held in Conjunction with MICCAI 2010, Beijing, China, September 20, 2010. Proceedings (pp. 42-49). Springer. Lecture notes in computer science Vol. 6357 https://doi.org/10.1007/978-3-642-15948-0_6

Prediction of dementia by hippocampal shape analysis. / Achterberg, Hakim C.; van der Lijn, Fedde; den Heijer, Tom et al.

Machine Learning in Medical Imaging: First International Workshop, MLMI 2010, Held in Conjunction with MICCAI 2010, Beijing, China, September 20, 2010. Proceedings. ed. / Fei Wang; Pingkun Yan; Kenji Suzuki; Dinggang Shen. Springer, 2010. p. 42-49 (Lecture notes in computer science, Vol. 6357).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Achterberg, HC, van der Lijn, F, den Heijer, T, van der Lugt, A, Breteler, MMB, Niessen, WJ & de Bruijne, M 2010, Prediction of dementia by hippocampal shape analysis. in F Wang, P Yan, K Suzuki & D Shen (eds), Machine Learning in Medical Imaging: First International Workshop, MLMI 2010, Held in Conjunction with MICCAI 2010, Beijing, China, September 20, 2010. Proceedings. Springer, Lecture notes in computer science, vol. 6357, pp. 42-49, 1st International Workshop on Machine Learning in Medical Imaging, Beijing, China, 20/09/2010. https://doi.org/10.1007/978-3-642-15948-0_6

Achterberg HC, van der Lijn F, den Heijer T, van der Lugt A, Breteler MMB, Niessen WJ et al. Prediction of dementia by hippocampal shape analysis. In Wang F, Yan P, Suzuki K, Shen D, editors, Machine Learning in Medical Imaging: First International Workshop, MLMI 2010, Held in Conjunction with MICCAI 2010, Beijing, China, September 20, 2010. Proceedings. Springer. 2010. p. 42-49. (Lecture notes in computer science, Vol. 6357). doi: 10.1007/978-3-642-15948-0_6

Achterberg, Hakim C. ; van der Lijn, Fedde ; den Heijer, Tom et al. / Prediction of dementia by hippocampal shape analysis. Machine Learning in Medical Imaging: First International Workshop, MLMI 2010, Held in Conjunction with MICCAI 2010, Beijing, China, September 20, 2010. Proceedings. editor / Fei Wang ; Pingkun Yan ; Kenji Suzuki ; Dinggang Shen. Springer, 2010. pp. 42-49 (Lecture notes in computer science, Vol. 6357).

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