PreBötzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation

TY - JOUR

T1 - PreBötzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation

AU - Rekling, J C

AU - Feldman, J L

N1 - Keywords: Animals; Biological Clocks; Brain Stem; Humans; Neurons; Respiratory Mechanics

PY - 1998

Y1 - 1998

N2 - Identification of the sites and mechanisms underlying the generation of respiratory rhythm is of longstanding interest to physiologists and neurobiologists. Recently, with the development of novel experimental preparations, especially in vitro en bloc and slice preparations of rodent brainstem, progress has been made In particular, a site in the ventrolateral medulla, the preBötzinger Complex, is hypothesized to contain neuronal circuits generating respiratory rhythm. Lesions or disruption of synaptic transmission within the preBötzinger Complex, either in vivo or in vitro, can abolish respiratory activity. Furthermore, the persistence of respiratory rhythm following interference with postsynaptic inhibition and the subsequent discovery of neurons with endogenous bursting properties within the preBötzinger Complex have led to the hypothesis that rhythmogenesis results from synchronized activity of pacemaker or group-pacemaker neurons.

AB - Identification of the sites and mechanisms underlying the generation of respiratory rhythm is of longstanding interest to physiologists and neurobiologists. Recently, with the development of novel experimental preparations, especially in vitro en bloc and slice preparations of rodent brainstem, progress has been made In particular, a site in the ventrolateral medulla, the preBötzinger Complex, is hypothesized to contain neuronal circuits generating respiratory rhythm. Lesions or disruption of synaptic transmission within the preBötzinger Complex, either in vivo or in vitro, can abolish respiratory activity. Furthermore, the persistence of respiratory rhythm following interference with postsynaptic inhibition and the subsequent discovery of neurons with endogenous bursting properties within the preBötzinger Complex have led to the hypothesis that rhythmogenesis results from synchronized activity of pacemaker or group-pacemaker neurons.

U2 - 10.1146/annurev.physiol.60.1.385

DO - 10.1146/annurev.physiol.60.1.385

M3 - Journal article

C2 - 9558470

SN - 0066-4278

VL - 60

SP - 385

EP - 405

JO - Annual Review of Physiology

JF - Annual Review of Physiology

ER -