Potential involvement of the proton-coupled amino acid transporter PAT1 (SLC36A1) in the delivery of pharmaceutical agents

Sidsel Balsgaard Frølund; Martha Kampp Nøhr; René Holm; Birger Brodin; Carsten Uhd Nielsen

Potential involvement of the proton-coupled amino acid transporter PAT1 (SLC36A1) in the delivery of pharmaceutical agents

Sidsel Balsgaard Frølund, Martha Kampp Nøhr, René Holm, Birger Brodin, Carsten Uhd Nielsen

4 Citations (Scopus)

Abstract

The proton-coupled amino acid transporter PAT1 (SLC36A1) is an intestinal carrier of L-proline, L-alanine and glycine. PAT1 has also been shown to transport pharmacologically active substances such as GABA, vigabatrin, δ-aminolevulinic acid and gaboxadol. The present review will discuss if the proton-coupled amino acid transporter PAT1 (SLC36A1) may be a relevant transporter for pharmaceutical exploitation. Research investigating this from both in vitro and in vivo perspectives will be highlighted. Furthermore we'll review the current knowledge about the structure-translocation relationship for PAT1 and provide an overview of pharmacological active substances, which are substrates for PAT1 along with examples of formulation strategies aimed at exploiting the transport activity of PAT1.

Original language	English
Journal	Journal of Drug Delivery Science and Technology
Volume	23
Issue number	4
Pages (from-to)	293-306
ISSN	1773-2247
Publication status	Published - 2013

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title = "Potential involvement of the proton-coupled amino acid transporter PAT1 (SLC36A1) in the delivery of pharmaceutical agents",

abstract = "The proton-coupled amino acid transporter PAT1 (SLC36A1) is an intestinal carrier of L-proline, L-alanine and glycine. PAT1 has also been shown to transport pharmacologically active substances such as GABA, vigabatrin, δ-aminolevulinic acid and gaboxadol. The present review will discuss if the proton-coupled amino acid transporter PAT1 (SLC36A1) may be a relevant transporter for pharmaceutical exploitation. Research investigating this from both in vitro and in vivo perspectives will be highlighted. Furthermore we'll review the current knowledge about the structure-translocation relationship for PAT1 and provide an overview of pharmacological active substances, which are substrates for PAT1 along with examples of formulation strategies aimed at exploiting the transport activity of PAT1.",

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T1 - Potential involvement of the proton-coupled amino acid transporter PAT1 (SLC36A1) in the delivery of pharmaceutical agents

AU - Frølund, Sidsel Balsgaard

AU - Nøhr, Martha Kampp

AU - Holm, René

AU - Brodin, Birger

AU - Nielsen, Carsten Uhd

N1 - DOI findes ikke.

PY - 2013

Y1 - 2013

N2 - The proton-coupled amino acid transporter PAT1 (SLC36A1) is an intestinal carrier of L-proline, L-alanine and glycine. PAT1 has also been shown to transport pharmacologically active substances such as GABA, vigabatrin, δ-aminolevulinic acid and gaboxadol. The present review will discuss if the proton-coupled amino acid transporter PAT1 (SLC36A1) may be a relevant transporter for pharmaceutical exploitation. Research investigating this from both in vitro and in vivo perspectives will be highlighted. Furthermore we'll review the current knowledge about the structure-translocation relationship for PAT1 and provide an overview of pharmacological active substances, which are substrates for PAT1 along with examples of formulation strategies aimed at exploiting the transport activity of PAT1.

AB - The proton-coupled amino acid transporter PAT1 (SLC36A1) is an intestinal carrier of L-proline, L-alanine and glycine. PAT1 has also been shown to transport pharmacologically active substances such as GABA, vigabatrin, δ-aminolevulinic acid and gaboxadol. The present review will discuss if the proton-coupled amino acid transporter PAT1 (SLC36A1) may be a relevant transporter for pharmaceutical exploitation. Research investigating this from both in vitro and in vivo perspectives will be highlighted. Furthermore we'll review the current knowledge about the structure-translocation relationship for PAT1 and provide an overview of pharmacological active substances, which are substrates for PAT1 along with examples of formulation strategies aimed at exploiting the transport activity of PAT1.

M3 - Journal article

SN - 1773-2247

VL - 23

SP - 293

EP - 306

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

IS - 4

ER -

Potential involvement of the proton-coupled amino acid transporter PAT1 (SLC36A1) in the delivery of pharmaceutical agents

Abstract

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