Possible early detection of coronary artery calcium progression in type 1 diabetes: A case-control study of normoalbuminuric type 1 diabetes patients and matched controls

Henrik Ø Hjortkjær; Tonny Jensen; Jannik Hilsted; Helle Corinth; Ulrik M Mogensen; Lars Køber; Andreas Fuchs; Børge G Nordestgaard; Klaus F Kofoed

doi:10.1016/j.diabres.2018.04.027

Possible early detection of coronary artery calcium progression in type 1 diabetes: A case-control study of normoalbuminuric type 1 diabetes patients and matched controls

Henrik Ø Hjortkjær, Tonny Jensen, Jannik Hilsted, Helle Corinth, Ulrik M Mogensen, Lars Køber, Andreas Fuchs, Børge G Nordestgaard, Klaus F Kofoed

Department of Clinical Medicine

1 Citation (Scopus)

Abstract

AIMS: Coronary artery calcium (CAC) is associated with cardiovascular (CV) disease and progression of CAC is an independent predictor of mortality. Type 1 diabetes is associated with increased CV risk, especially in persons with cardiovascular autonomic neuropathy (CAN). This study aimed to examine whether short-term progression of CAC is increased in persons with type 1 diabetes compared to matched controls and if CAN increases risk of CAC progression.

METHODS: Fifty-three normoalbuminuric persons with long-term type 1 diabetes (20 with CAN) were matched in a 1:2 ratio with 106 controls without diabetes according to age, sex and baseline CAC. All were examined twice with cardiac computed tomography scans. Progression of CAC was defined as a value ≥2.5 between the square root-transformed values of follow-up and baseline CAC volume scores.

RESULTS: The participants were examined median (interquartile range) of 25 (23-27) months (type 1 diabetes) and 29 (25-33) months (controls) apart. In multivariable logistic regression, participants with type 1 diabetes had an odds ratio of 3.3 (95% CI 1.3-8.2, p = 0.01) for CAC progression. CAN did not increase progression of CAC (p = 0.64).

CONCLUSIONS: Progression of CAC was increased in well-treated, normoalbuminuric persons with type 1 diabetes compared to matched controls without diabetes, suggesting that type 1 diabetes is a risk factor for short-term progression. This finding could explain some of the increased morbidity and mortality observed in persons with type 1 diabetes, but it does not specifically explain the increased CV risk in persons with CAN.

Original language	English
Journal	Diabetes Research and Clinical Practice
Volume	141
Pages (from-to)	18-25
Number of pages	8
ISSN	0168-8227
DOIs	https://doi.org/10.1016/j.diabres.2018.04.027
Publication status	Published - Jul 2018

Keywords

Calcium/metabolism
Cardiovascular Diseases/complications
Case-Control Studies
Coronary Artery Disease/diagnosis
Diabetes Mellitus, Type 1/complications
Disease Progression
Early Diagnosis
Female
Humans
Male
Middle Aged
Risk Factors
Serum Albumin/metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2018.04.027

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Hjortkjær, H. Ø., Jensen, T., Hilsted, J., Corinth, H., Mogensen, U. M., Køber, L., Fuchs, A., Nordestgaard, B. G., & Kofoed, K. F. (2018). Possible early detection of coronary artery calcium progression in type 1 diabetes: A case-control study of normoalbuminuric type 1 diabetes patients and matched controls. Diabetes Research and Clinical Practice, 141, 18-25. https://doi.org/10.1016/j.diabres.2018.04.027

Possible early detection of coronary artery calcium progression in type 1 diabetes: A case-control study of normoalbuminuric type 1 diabetes patients and matched controls. / Hjortkjær, Henrik Ø; Jensen, Tonny; Hilsted, Jannik et al.
In: Diabetes Research and Clinical Practice, Vol. 141, 07.2018, p. 18-25.

Research output: Contribution to journal › Journal article › Research › peer-review

Hjortkjær, HØ, Jensen, T, Hilsted, J, Corinth, H, Mogensen, UM, Køber, L, Fuchs, A, Nordestgaard, BG & Kofoed, KF 2018, 'Possible early detection of coronary artery calcium progression in type 1 diabetes: A case-control study of normoalbuminuric type 1 diabetes patients and matched controls', Diabetes Research and Clinical Practice, vol. 141, pp. 18-25. https://doi.org/10.1016/j.diabres.2018.04.027

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title = "Possible early detection of coronary artery calcium progression in type 1 diabetes: A case-control study of normoalbuminuric type 1 diabetes patients and matched controls",

abstract = "AIMS: Coronary artery calcium (CAC) is associated with cardiovascular (CV) disease and progression of CAC is an independent predictor of mortality. Type 1 diabetes is associated with increased CV risk, especially in persons with cardiovascular autonomic neuropathy (CAN). This study aimed to examine whether short-term progression of CAC is increased in persons with type 1 diabetes compared to matched controls and if CAN increases risk of CAC progression.METHODS: Fifty-three normoalbuminuric persons with long-term type 1 diabetes (20 with CAN) were matched in a 1:2 ratio with 106 controls without diabetes according to age, sex and baseline CAC. All were examined twice with cardiac computed tomography scans. Progression of CAC was defined as a value ≥2.5 between the square root-transformed values of follow-up and baseline CAC volume scores.RESULTS: The participants were examined median (interquartile range) of 25 (23-27) months (type 1 diabetes) and 29 (25-33) months (controls) apart. In multivariable logistic regression, participants with type 1 diabetes had an odds ratio of 3.3 (95% CI 1.3-8.2, p = 0.01) for CAC progression. CAN did not increase progression of CAC (p = 0.64).CONCLUSIONS: Progression of CAC was increased in well-treated, normoalbuminuric persons with type 1 diabetes compared to matched controls without diabetes, suggesting that type 1 diabetes is a risk factor for short-term progression. This finding could explain some of the increased morbidity and mortality observed in persons with type 1 diabetes, but it does not specifically explain the increased CV risk in persons with CAN.",

keywords = "Calcium/metabolism, Cardiovascular Diseases/complications, Case-Control Studies, Coronary Artery Disease/diagnosis, Diabetes Mellitus, Type 1/complications, Disease Progression, Early Diagnosis, Female, Humans, Male, Middle Aged, Risk Factors, Serum Albumin/metabolism",

author = "Hjortkj{\ae}r, {Henrik {\O}} and Tonny Jensen and Jannik Hilsted and Helle Corinth and Mogensen, {Ulrik M} and Lars K{\o}ber and Andreas Fuchs and Nordestgaard, {B{\o}rge G} and Kofoed, {Klaus F}",

year = "2018",

month = jul,

doi = "10.1016/j.diabres.2018.04.027",

language = "English",

volume = "141",

pages = "18--25",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Possible early detection of coronary artery calcium progression in type 1 diabetes

T2 - A case-control study of normoalbuminuric type 1 diabetes patients and matched controls

AU - Hjortkjær, Henrik Ø

AU - Jensen, Tonny

AU - Hilsted, Jannik

AU - Corinth, Helle

AU - Mogensen, Ulrik M

AU - Køber, Lars

AU - Fuchs, Andreas

AU - Nordestgaard, Børge G

AU - Kofoed, Klaus F

PY - 2018/7

Y1 - 2018/7

N2 - AIMS: Coronary artery calcium (CAC) is associated with cardiovascular (CV) disease and progression of CAC is an independent predictor of mortality. Type 1 diabetes is associated with increased CV risk, especially in persons with cardiovascular autonomic neuropathy (CAN). This study aimed to examine whether short-term progression of CAC is increased in persons with type 1 diabetes compared to matched controls and if CAN increases risk of CAC progression.METHODS: Fifty-three normoalbuminuric persons with long-term type 1 diabetes (20 with CAN) were matched in a 1:2 ratio with 106 controls without diabetes according to age, sex and baseline CAC. All were examined twice with cardiac computed tomography scans. Progression of CAC was defined as a value ≥2.5 between the square root-transformed values of follow-up and baseline CAC volume scores.RESULTS: The participants were examined median (interquartile range) of 25 (23-27) months (type 1 diabetes) and 29 (25-33) months (controls) apart. In multivariable logistic regression, participants with type 1 diabetes had an odds ratio of 3.3 (95% CI 1.3-8.2, p = 0.01) for CAC progression. CAN did not increase progression of CAC (p = 0.64).CONCLUSIONS: Progression of CAC was increased in well-treated, normoalbuminuric persons with type 1 diabetes compared to matched controls without diabetes, suggesting that type 1 diabetes is a risk factor for short-term progression. This finding could explain some of the increased morbidity and mortality observed in persons with type 1 diabetes, but it does not specifically explain the increased CV risk in persons with CAN.

AB - AIMS: Coronary artery calcium (CAC) is associated with cardiovascular (CV) disease and progression of CAC is an independent predictor of mortality. Type 1 diabetes is associated with increased CV risk, especially in persons with cardiovascular autonomic neuropathy (CAN). This study aimed to examine whether short-term progression of CAC is increased in persons with type 1 diabetes compared to matched controls and if CAN increases risk of CAC progression.METHODS: Fifty-three normoalbuminuric persons with long-term type 1 diabetes (20 with CAN) were matched in a 1:2 ratio with 106 controls without diabetes according to age, sex and baseline CAC. All were examined twice with cardiac computed tomography scans. Progression of CAC was defined as a value ≥2.5 between the square root-transformed values of follow-up and baseline CAC volume scores.RESULTS: The participants were examined median (interquartile range) of 25 (23-27) months (type 1 diabetes) and 29 (25-33) months (controls) apart. In multivariable logistic regression, participants with type 1 diabetes had an odds ratio of 3.3 (95% CI 1.3-8.2, p = 0.01) for CAC progression. CAN did not increase progression of CAC (p = 0.64).CONCLUSIONS: Progression of CAC was increased in well-treated, normoalbuminuric persons with type 1 diabetes compared to matched controls without diabetes, suggesting that type 1 diabetes is a risk factor for short-term progression. This finding could explain some of the increased morbidity and mortality observed in persons with type 1 diabetes, but it does not specifically explain the increased CV risk in persons with CAN.

KW - Calcium/metabolism

KW - Cardiovascular Diseases/complications

KW - Case-Control Studies

KW - Coronary Artery Disease/diagnosis

KW - Diabetes Mellitus, Type 1/complications

KW - Disease Progression

KW - Early Diagnosis

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Risk Factors

KW - Serum Albumin/metabolism

U2 - 10.1016/j.diabres.2018.04.027

DO - 10.1016/j.diabres.2018.04.027

M3 - Journal article

C2 - 29679631

SN - 0168-8227

VL - 141

SP - 18

EP - 25

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

ER -

Possible early detection of coronary artery calcium progression in type 1 diabetes: A case-control study of normoalbuminuric type 1 diabetes patients and matched controls

Abstract

Keywords

UN SDGs

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