Positive surgical margins and local recurrence after simple enucleation and standard partial nephrectomy for malignant renal tumors: systematic review of the literature and meta-analysis of prevalence

TY - JOUR

T1 - Positive surgical margins and local recurrence after simple enucleation and standard partial nephrectomy for malignant renal tumors

T2 - systematic review of the literature and meta-analysis of prevalence

AU - Minervini, Andrea

AU - Campi, Riccardo

AU - Sessa, Francesco

AU - Derweesh, Ithaar

AU - Kaouk, Jihad H

AU - Mari, Andrea

AU - Rha, Koon H

AU - Sessa, Maurizio

AU - Volpe, Alessandro

AU - Carini, Marco

AU - Uzzo, Robert G

PY - 2017/12

Y1 - 2017/12

N2 - INTRODUCTION: The definition of the safest width of healthy renal margin to achieve oncological efficacy and therefore of the safest resection technique (RT) during partial nephrectomy (PN) continues to be widely debated. The aim of this study is to evaluate the prevalence of positive surgical margins (PSM), loco-regional recurrence (LRR) and renal recurrence (RER) rates after simple enucleation (SE) and standard partial nephrectomy (SPN) for malignant renal tumors. EVIDENCE ACQUISITION: A systematic review of the English-language literature was performed through August 2016 using the Medline, Web of Science and Embase databases according to the PRISMA criteria. A systematic review and meta-analysis was performed in those studies that defined the exact anatomical location of recurrence after PN. EVIDENCE SYNTHESIS: Overall, 33 studies involving 11,282 patients were selected for quantitative analysis. At a median follow-up of 43 (SE) and 52 (SPN) months, the pooled estimates of the prevalence of PSMs, LRR and RER were 2.7% (95% CI: 1.5-4.6%, P

AB - INTRODUCTION: The definition of the safest width of healthy renal margin to achieve oncological efficacy and therefore of the safest resection technique (RT) during partial nephrectomy (PN) continues to be widely debated. The aim of this study is to evaluate the prevalence of positive surgical margins (PSM), loco-regional recurrence (LRR) and renal recurrence (RER) rates after simple enucleation (SE) and standard partial nephrectomy (SPN) for malignant renal tumors. EVIDENCE ACQUISITION: A systematic review of the English-language literature was performed through August 2016 using the Medline, Web of Science and Embase databases according to the PRISMA criteria. A systematic review and meta-analysis was performed in those studies that defined the exact anatomical location of recurrence after PN. EVIDENCE SYNTHESIS: Overall, 33 studies involving 11,282 patients were selected for quantitative analysis. At a median follow-up of 43 (SE) and 52 (SPN) months, the pooled estimates of the prevalence of PSMs, LRR and RER were 2.7% (95% CI: 1.5-4.6%, P

U2 - 10.23736/S0393-2249.17.02864-8

DO - 10.23736/S0393-2249.17.02864-8

M3 - Review

C2 - 28124871

SN - 0393-2249

VL - 69

SP - 523

EP - 538

JO - Minerva Urologica e Nefrologica

JF - Minerva Urologica e Nefrologica

IS - 6

ER -