Positive selection on the killer whale mitogenome

Andrew David Foote; Phillip A. Morin; John W. Durban; Robert L. Pitman; Paul Wade; Eske Willerslev; Tom Gilbert; Rute Andreia Rodrigues da Fonseca

doi:10.1098/rsbl.2010.0638

Positive selection on the killer whale mitogenome

Andrew David Foote, Phillip A. Morin, John W. Durban, Robert L. Pitman, Paul Wade, Eske Willerslev, Tom Gilbert, Rute Andreia Rodrigues da Fonseca

79 Citations (Scopus)

Abstract

Mitochondria produce up to 95 per cent of the eukaryotic cell's energy. The coding genes of the mitochondrial DNA may therefore evolve under selection owing to metabolic requirements. The killer whale, Orcinus orca, is polymorphic, has a global distribution and occupies a range of ecological niches. It is therefore a suitable organism for testing this hypothesis. We compared a global dataset of the complete mitochondrial genomes of 139 individuals for amino acid changes that were associated with radical physico-chemical property changes and were influenced by positive selection. Two such selected non-synonymous amino acid changes were found; one in each of two ecotypes that inhabit the Antarctic pack ice. Both substitutions were associated with changes in local polarity, increased steric constraints and a-helical tendencies that could influence overall metabolic performance, suggesting a functional change. This journal is

Original language	English
Journal	Biology Letters
Volume	7
Issue number	1
Pages (from-to)	116-118
Number of pages	3
ISSN	1744-9561
DOIs	https://doi.org/10.1098/rsbl.2010.0638
Publication status	Published - 23 Feb 2011

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title = "Positive selection on the killer whale mitogenome",

abstract = "Mitochondria produce up to 95 per cent of the eukaryotic cell's energy. The coding genes of the mitochondrial DNA may therefore evolve under selection owing to metabolic requirements. The killer whale, Orcinus orca, is polymorphic, has a global distribution and occupies a range of ecological niches. It is therefore a suitable organism for testing this hypothesis. We compared a global dataset of the complete mitochondrial genomes of 139 individuals for amino acid changes that were associated with radical physico-chemical property changes and were influenced by positive selection. Two such selected non-synonymous amino acid changes were found; one in each of two ecotypes that inhabit the Antarctic pack ice. Both substitutions were associated with changes in local polarity, increased steric constraints and a-helical tendencies that could influence overall metabolic performance, suggesting a functional change. This journal is",

author = "Foote, {Andrew David} and Morin, {Phillip A.} and Durban, {John W.} and Pitman, {Robert L.} and Paul Wade and Eske Willerslev and Tom Gilbert and {Rodrigues da Fonseca}, {Rute Andreia}",

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T1 - Positive selection on the killer whale mitogenome

AU - Foote, Andrew David

AU - Morin, Phillip A.

AU - Durban, John W.

AU - Pitman, Robert L.

AU - Wade, Paul

AU - Willerslev, Eske

AU - Gilbert, Tom

AU - Rodrigues da Fonseca, Rute Andreia

PY - 2011/2/23

Y1 - 2011/2/23

N2 - Mitochondria produce up to 95 per cent of the eukaryotic cell's energy. The coding genes of the mitochondrial DNA may therefore evolve under selection owing to metabolic requirements. The killer whale, Orcinus orca, is polymorphic, has a global distribution and occupies a range of ecological niches. It is therefore a suitable organism for testing this hypothesis. We compared a global dataset of the complete mitochondrial genomes of 139 individuals for amino acid changes that were associated with radical physico-chemical property changes and were influenced by positive selection. Two such selected non-synonymous amino acid changes were found; one in each of two ecotypes that inhabit the Antarctic pack ice. Both substitutions were associated with changes in local polarity, increased steric constraints and a-helical tendencies that could influence overall metabolic performance, suggesting a functional change. This journal is

AB - Mitochondria produce up to 95 per cent of the eukaryotic cell's energy. The coding genes of the mitochondrial DNA may therefore evolve under selection owing to metabolic requirements. The killer whale, Orcinus orca, is polymorphic, has a global distribution and occupies a range of ecological niches. It is therefore a suitable organism for testing this hypothesis. We compared a global dataset of the complete mitochondrial genomes of 139 individuals for amino acid changes that were associated with radical physico-chemical property changes and were influenced by positive selection. Two such selected non-synonymous amino acid changes were found; one in each of two ecotypes that inhabit the Antarctic pack ice. Both substitutions were associated with changes in local polarity, increased steric constraints and a-helical tendencies that could influence overall metabolic performance, suggesting a functional change. This journal is

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DO - 10.1098/rsbl.2010.0638

M3 - Letter

C2 - 20810427

SN - 1744-9561

VL - 7

SP - 116

EP - 118

JO - Biology Letters

JF - Biology Letters

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Positive selection on the killer whale mitogenome

Abstract

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