Porcine models of biofilm infections with focus on pathomorphology

Louise Kruse Jensen; Anne Sofie Boyum Johansen; Henrik Elvang Jensen

doi:10.3389/fmicb.2017.01961

Porcine models of biofilm infections with focus on pathomorphology

Louise Kruse Jensen, Anne Sofie Boyum Johansen, Henrik Elvang Jensen

8 Citations (Scopus)

59 Downloads (Pure)

Abstract

Bacterial biofilm formation is one of the main reasons for a negative treatment outcome and a high recurrence rate for many chronic infections in humans. The optimal way to study both the biofilm forming bacteria and the host response simultaneously is by using discriminative, reliable, and reproducible animal models of the infections. In this review, the advantages of in vivo studies are compared to in vitro studies of biofilm formation in infectious diseases. The pig is the animal of choice when developing and applying large animal models of infectious diseases due to its similarity of anatomy, physiology, and immune system to humans. Furthermore, conventional pigs spontaneously develop many of the same chronic bacterial infections as seen in humans. Therefore, in this review porcine models of five different infectious diseases all associated with biofilm formation and chronicity in humans are described. The infectious diseases are: chronic wounds, endocarditis, pyelonephritis, hematogenous osteomyelitis, and implant-associated osteomyelitis (IAO).

Original language	English
Article number	1961
Journal	Frontiers in Microbiology
Volume	8
Number of pages	16
ISSN	1664-302X
DOIs	https://doi.org/10.3389/fmicb.2017.01961
Publication status	Published - 10 Oct 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fmicb.2017.01961Licence: CC BY

Porcine Models of Biofilm Infections with Focus on PathomorphologyFinal published version, 4 MBLicence: CC BY

Cite this

@article{89e3327b1ba44edca249b3cd345a0e88,

title = "Porcine models of biofilm infections with focus on pathomorphology",

abstract = "Bacterial biofilm formation is one of the main reasons for a negative treatment outcome and a high recurrence rate for many chronic infections in humans. The optimal way to study both the biofilm forming bacteria and the host response simultaneously is by using discriminative, reliable, and reproducible animal models of the infections. In this review, the advantages of in vivo studies are compared to in vitro studies of biofilm formation in infectious diseases. The pig is the animal of choice when developing and applying large animal models of infectious diseases due to its similarity of anatomy, physiology, and immune system to humans. Furthermore, conventional pigs spontaneously develop many of the same chronic bacterial infections as seen in humans. Therefore, in this review porcine models of five different infectious diseases all associated with biofilm formation and chronicity in humans are described. The infectious diseases are: chronic wounds, endocarditis, pyelonephritis, hematogenous osteomyelitis, and implant-associated osteomyelitis (IAO).",

author = "Jensen, {Louise Kruse} and Johansen, {Anne Sofie Boyum} and Jensen, {Henrik Elvang}",

year = "2017",

month = oct,

day = "10",

doi = "10.3389/fmicb.2017.01961",

language = "English",

volume = "8",

journal = "Frontiers in Microbiology",

issn = "1664-302X",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - Porcine models of biofilm infections with focus on pathomorphology

AU - Jensen, Louise Kruse

AU - Johansen, Anne Sofie Boyum

AU - Jensen, Henrik Elvang

PY - 2017/10/10

Y1 - 2017/10/10

N2 - Bacterial biofilm formation is one of the main reasons for a negative treatment outcome and a high recurrence rate for many chronic infections in humans. The optimal way to study both the biofilm forming bacteria and the host response simultaneously is by using discriminative, reliable, and reproducible animal models of the infections. In this review, the advantages of in vivo studies are compared to in vitro studies of biofilm formation in infectious diseases. The pig is the animal of choice when developing and applying large animal models of infectious diseases due to its similarity of anatomy, physiology, and immune system to humans. Furthermore, conventional pigs spontaneously develop many of the same chronic bacterial infections as seen in humans. Therefore, in this review porcine models of five different infectious diseases all associated with biofilm formation and chronicity in humans are described. The infectious diseases are: chronic wounds, endocarditis, pyelonephritis, hematogenous osteomyelitis, and implant-associated osteomyelitis (IAO).

AB - Bacterial biofilm formation is one of the main reasons for a negative treatment outcome and a high recurrence rate for many chronic infections in humans. The optimal way to study both the biofilm forming bacteria and the host response simultaneously is by using discriminative, reliable, and reproducible animal models of the infections. In this review, the advantages of in vivo studies are compared to in vitro studies of biofilm formation in infectious diseases. The pig is the animal of choice when developing and applying large animal models of infectious diseases due to its similarity of anatomy, physiology, and immune system to humans. Furthermore, conventional pigs spontaneously develop many of the same chronic bacterial infections as seen in humans. Therefore, in this review porcine models of five different infectious diseases all associated with biofilm formation and chronicity in humans are described. The infectious diseases are: chronic wounds, endocarditis, pyelonephritis, hematogenous osteomyelitis, and implant-associated osteomyelitis (IAO).

U2 - 10.3389/fmicb.2017.01961

DO - 10.3389/fmicb.2017.01961

M3 - Review

C2 - 29067019

SN - 1664-302X

VL - 8

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

M1 - 1961

ER -

Porcine models of biofilm infections with focus on pathomorphology

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this