Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium

Catherine M Phelan; Ya-Yu Tsai; Ellen L Goode; Robert A Vierkant; Brooke L Fridley; Jonathan Beesley; Xiao Qing Chen; Penelope M Webb; Stephen Chanock; Daniel W Cramer; Kirsten Moysich; Robert P Edwards; Jenny Chang-Claude; Montserrat Garcia-Closas; Hannah Yang; Shan Wang-Gohrke; Rebecca Hein; Adele C Green; Jolanta Lissowska; Michael E Carney; Galina Lurie; Lynne R Wilkens; Roberta B Ness; Celeste Leigh Pearce; Anna H Wu; David J Van Den Berg; Daniel O Stram; Kathryn L Terry; David C Whiteman; Alice S Whittemore; Richard A DiCioccio; Valerie McGuire; Jennifer A Doherty; Mary Anne Rossing; Hoda Anton-Culver; Argyrios Ziogas; Claus Hogdall; Estrid Hogdall; Susanne Krüger Kjaer; Jan Blaakaer; Lydia Quaye; Susan J Ramus; Ian Jacobs; Honglin Song; Paul D P Pharoah; Edwin S Iversen; Jeffrey R Marks; Malcolm C Pike; Simon A Gayther; Julie M Cunningham; Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer)

doi:http://dx.doi.org/10.1158/1055-9965.EPI-09-0861

Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium

Catherine M Phelan, Ya-Yu Tsai, Ellen L Goode, Robert A Vierkant, Brooke L Fridley, Jonathan Beesley, Xiao Qing Chen, Penelope M Webb, Stephen Chanock, Daniel W Cramer, Kirsten Moysich, Robert P Edwards, Jenny Chang-Claude, Montserrat Garcia-Closas, Hannah Yang, Shan Wang-Gohrke, Rebecca Hein, Adele C Green, Jolanta Lissowska, Michael E CarneyGalina Lurie, Lynne R Wilkens, Roberta B Ness, Celeste Leigh Pearce, Anna H Wu, David J Van Den Berg, Daniel O Stram, Kathryn L Terry, David C Whiteman, Alice S Whittemore, Richard A DiCioccio, Valerie McGuire, Jennifer A Doherty, Mary Anne Rossing, Hoda Anton-Culver, Argyrios Ziogas, Claus Hogdall, Estrid Hogdall, Susanne Krüger Kjaer, Jan Blaakaer, Lydia Quaye, Susan J Ramus, Ian Jacobs, Honglin Song, Paul D P Pharoah, Edwin S Iversen, Jeffrey R Marks, Malcolm C Pike, Simon A Gayther, Julie M Cunningham, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer)

Faculty of Health and Medical Sciences

20 Citations (Scopus)

Abstract

Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.

Original language	English
Journal	Cancer Epidemiology, Biomarkers & Prevention
Volume	19
Issue number	2
Pages (from-to)	600-4
Number of pages	5
ISSN	1055-9965
DOIs	https://doi.org/10.1158/1055-9965.EPI-09-0861
Publication status	Published - 1 Feb 2010

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Phelan, C. M., Tsai, Y-Y., Goode, E. L., Vierkant, R. A., Fridley, B. L., Beesley, J., Chen, X. Q., Webb, P. M., Chanock, S., Cramer, D. W., Moysich, K., Edwards, R. P., Chang-Claude, J., Garcia-Closas, M., Yang, H., Wang-Gohrke, S., Hein, R., Green, A. C., Lissowska, J., ... Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer) (2010). Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium. Cancer Epidemiology, Biomarkers & Prevention, 19(2), 600-4. https://doi.org/10.1158/1055-9965.EPI-09-0861

Phelan, CM, Tsai, Y-Y, Goode, EL, Vierkant, RA, Fridley, BL, Beesley, J, Chen, XQ, Webb, PM, Chanock, S, Cramer, DW, Moysich, K, Edwards, RP, Chang-Claude, J, Garcia-Closas, M, Yang, H, Wang-Gohrke, S, Hein, R, Green, AC, Lissowska, J, Carney, ME, Lurie, G, Wilkens, LR, Ness, RB, Pearce, CL, Wu, AH, Van Den Berg, DJ, Stram, DO, Terry, KL, Whiteman, DC, Whittemore, AS, DiCioccio, RA, McGuire, V, Doherty, JA, Rossing, MA, Anton-Culver, H, Ziogas, A, Hogdall, C, Hogdall, E, Krüger Kjaer, S, Blaakaer, J, Quaye, L, Ramus, SJ, Jacobs, I, Song, H, Pharoah, PDP, Iversen, ES, Marks, JR, Pike, MC, Gayther, SA, Cunningham, JM & Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer) 2010, 'Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium', Cancer Epidemiology, Biomarkers & Prevention, vol. 19, no. 2, pp. 600-4. https://doi.org/10.1158/1055-9965.EPI-09-0861

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title = "Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium",

abstract = "Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.",

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T1 - Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium

AU - Phelan, Catherine M

AU - Tsai, Ya-Yu

AU - Goode, Ellen L

AU - Vierkant, Robert A

AU - Fridley, Brooke L

AU - Beesley, Jonathan

AU - Chen, Xiao Qing

AU - Webb, Penelope M

AU - Chanock, Stephen

AU - Cramer, Daniel W

AU - Moysich, Kirsten

AU - Edwards, Robert P

AU - Chang-Claude, Jenny

AU - Garcia-Closas, Montserrat

AU - Yang, Hannah

AU - Wang-Gohrke, Shan

AU - Hein, Rebecca

AU - Green, Adele C

AU - Lissowska, Jolanta

AU - Carney, Michael E

AU - Lurie, Galina

AU - Wilkens, Lynne R

AU - Ness, Roberta B

AU - Pearce, Celeste Leigh

AU - Wu, Anna H

AU - Van Den Berg, David J

AU - Stram, Daniel O

AU - Terry, Kathryn L

AU - Whiteman, David C

AU - Whittemore, Alice S

AU - DiCioccio, Richard A

AU - McGuire, Valerie

AU - Doherty, Jennifer A

AU - Rossing, Mary Anne

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Hogdall, Claus

AU - Hogdall, Estrid

AU - Krüger Kjaer, Susanne

AU - Blaakaer, Jan

AU - Quaye, Lydia

AU - Ramus, Susan J

AU - Jacobs, Ian

AU - Song, Honglin

AU - Pharoah, Paul D P

AU - Iversen, Edwin S

AU - Marks, Jeffrey R

AU - Pike, Malcolm C

AU - Gayther, Simon A

AU - Cunningham, Julie M

AU - Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer)

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N2 - Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.

AB - Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.

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DO - http://dx.doi.org/10.1158/1055-9965.EPI-09-0861

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JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

IS - 2

ER -

Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium

Abstract

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