Polygenic risk for psychiatric disorder and singleness in patients with severe mental illness and controls

Carsten Hjorthøj; Md Jamal Uddin; David Michael Hougaard; Holger J Sørensen; Merete Nordentoft

doi:10.1016/j.jpsychires.2019.09.013

Polygenic risk for psychiatric disorder and singleness in patients with severe mental illness and controls

Carsten Hjorthøj, Md Jamal Uddin, David Michael Hougaard, Holger J Sørensen, Merete Nordentoft

2 Citations (Scopus)

Abstract

We aimed to investigate whether the polygenic risk score (PRS) for schizophrenia influences time in couple relationships for patients with severe mental illness and controls. We combined the nationwide Danish registers with genetic information from dried neonatal blood spots. We included 2,599 individuals with schizophrenia, 1,446 with bipolar disorder, 20,315 with depression, and 6,963 controls. PRS for schizophrenia, depression, and bipolar disorder were estimated using data from the Psychiatric Genetics Consortium and analyzed both as a scale-predictor and as highest versus other deciles. The main outcome was number of days in couple relationships. Patients with schizophrenia had markedly fewer days/year in couple relationships: 64 (95% CI; 61-69) than patients with depression: 119 (95% CI; 117-121), bipolar disorder: 103 (95% CI 97-110), and controls: 136 (95% CI 133-139). PRS for schizophrenia was associated with fewer days in couple relationships in patients with schizophrenia (scale-PRS: IRR = 0.95 (0.93-0.97)) or depression (highest decile: IRR = 0.93 (0.87-0.98)). PRS for bipolar disorder (as scale) was also associated with fewer days in couple relationships in patients with depression (IRR = 0.99 (0.99-1.00)) or bipolar disorder (IRR = 0.96 (0.94-0.99)) and controls (IRR = 0.99 (0.97-1.00), and IRR = 0.89 (0.81-0.98) for the highest decile). Due to the number of statistical tests, however, it cannot be concluded definitely that some of these may not be spurious findings. In conclusion, our findings implicate high genetic loading for schizophrenia as a predisposing factor to singleness in patients with schizophrenia or depression, and genetic loading for bipolar disorder a similar predisposing factor in patients with depression, bipolar disorder or controls.

Original language	English
Journal	Journal of Psychiatric Research
Volume	119
Pages (from-to)	60-66
Number of pages	7
ISSN	0022-3956
DOIs	https://doi.org/10.1016/j.jpsychires.2019.09.013
Publication status	Published - Dec 2019

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@article{e494d9913b33427c8c5c6373704fd0bd,

title = "Polygenic risk for psychiatric disorder and singleness in patients with severe mental illness and controls",

abstract = "We aimed to investigate whether the polygenic risk score (PRS) for schizophrenia influences time in couple relationships for patients with severe mental illness and controls. We combined the nationwide Danish registers with genetic information from dried neonatal blood spots. We included 2,599 individuals with schizophrenia, 1,446 with bipolar disorder, 20,315 with depression, and 6,963 controls. PRS for schizophrenia, depression, and bipolar disorder were estimated using data from the Psychiatric Genetics Consortium and analyzed both as a scale-predictor and as highest versus other deciles. The main outcome was number of days in couple relationships. Patients with schizophrenia had markedly fewer days/year in couple relationships: 64 (95% CI; 61-69) than patients with depression: 119 (95% CI; 117-121), bipolar disorder: 103 (95% CI 97-110), and controls: 136 (95% CI 133-139). PRS for schizophrenia was associated with fewer days in couple relationships in patients with schizophrenia (scale-PRS: IRR = 0.95 (0.93-0.97)) or depression (highest decile: IRR = 0.93 (0.87-0.98)). PRS for bipolar disorder (as scale) was also associated with fewer days in couple relationships in patients with depression (IRR = 0.99 (0.99-1.00)) or bipolar disorder (IRR = 0.96 (0.94-0.99)) and controls (IRR = 0.99 (0.97-1.00), and IRR = 0.89 (0.81-0.98) for the highest decile). Due to the number of statistical tests, however, it cannot be concluded definitely that some of these may not be spurious findings. In conclusion, our findings implicate high genetic loading for schizophrenia as a predisposing factor to singleness in patients with schizophrenia or depression, and genetic loading for bipolar disorder a similar predisposing factor in patients with depression, bipolar disorder or controls.",

author = "Carsten Hjorth{\o}j and Uddin, {Md Jamal} and Hougaard, {David Michael} and S{\o}rensen, {Holger J} and Merete Nordentoft",

year = "2019",

month = dec,

doi = "10.1016/j.jpsychires.2019.09.013",

language = "English",

volume = "119",

pages = "60--66",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

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T1 - Polygenic risk for psychiatric disorder and singleness in patients with severe mental illness and controls

AU - Hjorthøj, Carsten

AU - Uddin, Md Jamal

AU - Hougaard, David Michael

AU - Sørensen, Holger J

AU - Nordentoft, Merete

PY - 2019/12

Y1 - 2019/12

N2 - We aimed to investigate whether the polygenic risk score (PRS) for schizophrenia influences time in couple relationships for patients with severe mental illness and controls. We combined the nationwide Danish registers with genetic information from dried neonatal blood spots. We included 2,599 individuals with schizophrenia, 1,446 with bipolar disorder, 20,315 with depression, and 6,963 controls. PRS for schizophrenia, depression, and bipolar disorder were estimated using data from the Psychiatric Genetics Consortium and analyzed both as a scale-predictor and as highest versus other deciles. The main outcome was number of days in couple relationships. Patients with schizophrenia had markedly fewer days/year in couple relationships: 64 (95% CI; 61-69) than patients with depression: 119 (95% CI; 117-121), bipolar disorder: 103 (95% CI 97-110), and controls: 136 (95% CI 133-139). PRS for schizophrenia was associated with fewer days in couple relationships in patients with schizophrenia (scale-PRS: IRR = 0.95 (0.93-0.97)) or depression (highest decile: IRR = 0.93 (0.87-0.98)). PRS for bipolar disorder (as scale) was also associated with fewer days in couple relationships in patients with depression (IRR = 0.99 (0.99-1.00)) or bipolar disorder (IRR = 0.96 (0.94-0.99)) and controls (IRR = 0.99 (0.97-1.00), and IRR = 0.89 (0.81-0.98) for the highest decile). Due to the number of statistical tests, however, it cannot be concluded definitely that some of these may not be spurious findings. In conclusion, our findings implicate high genetic loading for schizophrenia as a predisposing factor to singleness in patients with schizophrenia or depression, and genetic loading for bipolar disorder a similar predisposing factor in patients with depression, bipolar disorder or controls.

AB - We aimed to investigate whether the polygenic risk score (PRS) for schizophrenia influences time in couple relationships for patients with severe mental illness and controls. We combined the nationwide Danish registers with genetic information from dried neonatal blood spots. We included 2,599 individuals with schizophrenia, 1,446 with bipolar disorder, 20,315 with depression, and 6,963 controls. PRS for schizophrenia, depression, and bipolar disorder were estimated using data from the Psychiatric Genetics Consortium and analyzed both as a scale-predictor and as highest versus other deciles. The main outcome was number of days in couple relationships. Patients with schizophrenia had markedly fewer days/year in couple relationships: 64 (95% CI; 61-69) than patients with depression: 119 (95% CI; 117-121), bipolar disorder: 103 (95% CI 97-110), and controls: 136 (95% CI 133-139). PRS for schizophrenia was associated with fewer days in couple relationships in patients with schizophrenia (scale-PRS: IRR = 0.95 (0.93-0.97)) or depression (highest decile: IRR = 0.93 (0.87-0.98)). PRS for bipolar disorder (as scale) was also associated with fewer days in couple relationships in patients with depression (IRR = 0.99 (0.99-1.00)) or bipolar disorder (IRR = 0.96 (0.94-0.99)) and controls (IRR = 0.99 (0.97-1.00), and IRR = 0.89 (0.81-0.98) for the highest decile). Due to the number of statistical tests, however, it cannot be concluded definitely that some of these may not be spurious findings. In conclusion, our findings implicate high genetic loading for schizophrenia as a predisposing factor to singleness in patients with schizophrenia or depression, and genetic loading for bipolar disorder a similar predisposing factor in patients with depression, bipolar disorder or controls.

U2 - 10.1016/j.jpsychires.2019.09.013

DO - 10.1016/j.jpsychires.2019.09.013

M3 - Journal article

C2 - 31563858

SN - 0022-3956

VL - 119

SP - 60

EP - 66

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

ER -

Polygenic risk for psychiatric disorder and singleness in patients with severe mental illness and controls

Abstract

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