Abstract
OBJECTIVE: To evaluate the plasma level of YKL-40 in a Danish polycystic ovary syndrome (PCOS) population and to investigate whether YKL-40 is associated with CVD risk factors such as waist circumference, body mass index (BMI), insulin resistance (IR), fasting glucose, fasting insulin, blood lipids and CRP.
DESIGN: Cross-sectional study.
SETTING: Gynecological clinics at three Danish University Hospitals.
PATIENTS: One hundred seventy-one premenopausal women with PCOS recruited consecutively from April 2010 to February 2012. PCOS was diagnosed according to the Rotterdam criteria.
MAIN OUTCOME MEASURES: Plasma level of YKL-40 in four phenotypes of PCOS defined by BMI and IR.
RESULTS: No statistically significant difference was observed in the plasma level of YKL-40 across the four BMI/IR-phenotypes. Positive associations were observed between YKL-40 and BMI, total and free testosterone, triglycerides, and CRP. Total and free testosterone were independent predictors of YKL-40.
CONCLUSION: YKL-40, the marker of low-grade inflammation is not increased in women with PCOS.
| Original language | English |
|---|---|
| Journal | Gynecological Endocrinology |
| Volume | 30 |
| Issue number | 4 |
| Pages (from-to) | 311-315 |
| Number of pages | 5 |
| ISSN | 0951-3590 |
| DOIs | |
| Publication status | Published - Apr 2014 |
Keywords
- Adipokines
- Adolescent
- Adult
- Biological Markers
- Body Mass Index
- C-Reactive Protein
- Cross-Sectional Studies
- Denmark
- Female
- Humans
- Inflammation
- Insulin
- Insulin Resistance
- Lectins
- Polycystic Ovary Syndrome
- Prospective Studies
- Regression Analysis
- Triglycerides
- Waist Circumference
- Young Adult