Polycomb complexes and silencing mechanisms.

Anders H Lund; Maarten van Lohuizen

doi:10.1016/j.ceb.2004.03.010

Polycomb complexes and silencing mechanisms.

Anders H Lund, Maarten van Lohuizen

244 Citations (Scopus)

Abstract

Advances in the past couple of years have brought important new knowledge on the mechanisms by which Polycomb-group proteins regulate gene expression and on the consequences of their actions. The discovery of histone methylation imprints specific for Polycomb and Trithorax complexes has provided mechanistic insight on how this ancient epigenetic memory system acts to repress and indicates that it may share mechanistic aspects with other silencing and genome-protective processes, such as RNA interference.

Original language	English
Journal	Current Opinion in Cell Biology
Volume	16
Issue number	3
Pages (from-to)	239-46
Number of pages	7
ISSN	0955-0674
DOIs	https://doi.org/10.1016/j.ceb.2004.03.010
Publication status	Published - 2004

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10.1016/j.ceb.2004.03.010

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title = "Polycomb complexes and silencing mechanisms.",

abstract = "Advances in the past couple of years have brought important new knowledge on the mechanisms by which Polycomb-group proteins regulate gene expression and on the consequences of their actions. The discovery of histone methylation imprints specific for Polycomb and Trithorax complexes has provided mechanistic insight on how this ancient epigenetic memory system acts to repress and indicates that it may share mechanistic aspects with other silencing and genome-protective processes, such as RNA interference.",

author = "Lund, {Anders H} and {van Lohuizen}, Maarten",

note = "Keywords: Animals; DNA-Binding Proteins; Drosophila; Drosophila Proteins; Gene Silencing; Histones; Protein Transport; Transcription Factors",

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AU - Lund, Anders H

AU - van Lohuizen, Maarten

N1 - Keywords: Animals; DNA-Binding Proteins; Drosophila; Drosophila Proteins; Gene Silencing; Histones; Protein Transport; Transcription Factors

PY - 2004

Y1 - 2004

N2 - Advances in the past couple of years have brought important new knowledge on the mechanisms by which Polycomb-group proteins regulate gene expression and on the consequences of their actions. The discovery of histone methylation imprints specific for Polycomb and Trithorax complexes has provided mechanistic insight on how this ancient epigenetic memory system acts to repress and indicates that it may share mechanistic aspects with other silencing and genome-protective processes, such as RNA interference.

AB - Advances in the past couple of years have brought important new knowledge on the mechanisms by which Polycomb-group proteins regulate gene expression and on the consequences of their actions. The discovery of histone methylation imprints specific for Polycomb and Trithorax complexes has provided mechanistic insight on how this ancient epigenetic memory system acts to repress and indicates that it may share mechanistic aspects with other silencing and genome-protective processes, such as RNA interference.

U2 - 10.1016/j.ceb.2004.03.010

DO - 10.1016/j.ceb.2004.03.010

M3 - Journal article

C2 - 15145347

SN - 0955-0674

VL - 16

SP - 239

EP - 246

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 3

ER -

Polycomb complexes and silencing mechanisms.

Abstract

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