Plasma YKL-40 levels in healthy subjects from the general population

Stig E Bojesen; Julia S Johansen; Børge G Nordestgaard

doi:10.1016/j.cca.2011.01.022

Plasma YKL-40 levels in healthy subjects from the general population

Stig E Bojesen, Julia S Johansen, Børge G Nordestgaard

82 Citations (Scopus)

Abstract

Background: Plasma YKL-40 is a new biomarker in patients with cancer and inflammatory diseases. High plasma YKL-40 is associated with poor prognosis. Our aim was to determine reference levels in healthy subjects. Methods: Plasma YKL-40 was determined in 3130 participants aged 20-80. years from the Danish general population, the Copenhagen City Heart Study. They had no known disease at time of blood sampling in 1991-1994 and remained healthy and alive during a 16-year follow-up period. In 644 participants, YKL-40 was measured again in samples taken 10. years after the first. Results: The median plasma YKL-40 was 40 μg/L (2.5-97.5% reference levels: 14-155) with no difference between sexes. YKL-40 increased exponentially with age. For age-adjusted reference levels, the YKL-40 percentile as a function of age in years and plasma YKL-40 in μg/L was derived: percentile = 100. /. (1. +. (YKL-40. ^-3).*(1.062. ^. age).*5000). In subjects with two YKL-40 measurements 10. years apart, the mean increase in YKL-40 was 1.5 μg/L/year (SE: 0.2), while the mean change in the calculated age percentile was minimal (-0.3; SE: 0.1). Conclusions: Plasma YKL-40 increases with age within and across healthy individuals from the general population. Age-stratified or age-adjusted reference levels are important when YKL-40 test results are evaluated.

Original language	English
Journal	Clinica Chimica Acta
Volume	412
Issue number	9-10
Pages (from-to)	709-12
Number of pages	4
ISSN	0009-8981
DOIs	https://doi.org/10.1016/j.cca.2011.01.022
Publication status	Published - 11 Apr 2011

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@article{2485617c48064d8b8148bd22f60717df,

title = "Plasma YKL-40 levels in healthy subjects from the general population",

abstract = "Background: Plasma YKL-40 is a new biomarker in patients with cancer and inflammatory diseases. High plasma YKL-40 is associated with poor prognosis. Our aim was to determine reference levels in healthy subjects. Methods: Plasma YKL-40 was determined in 3130 participants aged 20-80. years from the Danish general population, the Copenhagen City Heart Study. They had no known disease at time of blood sampling in 1991-1994 and remained healthy and alive during a 16-year follow-up period. In 644 participants, YKL-40 was measured again in samples taken 10. years after the first. Results: The median plasma YKL-40 was 40 μg/L (2.5-97.5% reference levels: 14-155) with no difference between sexes. YKL-40 increased exponentially with age. For age-adjusted reference levels, the YKL-40 percentile as a function of age in years and plasma YKL-40 in μg/L was derived: percentile = 100. /. (1. +. (YKL-40. ^-3).*(1.062. ^. age).*5000). In subjects with two YKL-40 measurements 10. years apart, the mean increase in YKL-40 was 1.5 μg/L/year (SE: 0.2), while the mean change in the calculated age percentile was minimal (-0.3; SE: 0.1). Conclusions: Plasma YKL-40 increases with age within and across healthy individuals from the general population. Age-stratified or age-adjusted reference levels are important when YKL-40 test results are evaluated.",

author = "Bojesen, {Stig E} and Johansen, {Julia S} and Nordestgaard, {B{\o}rge G}",

year = "2011",

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doi = "10.1016/j.cca.2011.01.022",

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volume = "412",

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journal = "Clinica Chimica Acta",

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T1 - Plasma YKL-40 levels in healthy subjects from the general population

AU - Bojesen, Stig E

AU - Johansen, Julia S

AU - Nordestgaard, Børge G

PY - 2011/4/11

Y1 - 2011/4/11

N2 - Background: Plasma YKL-40 is a new biomarker in patients with cancer and inflammatory diseases. High plasma YKL-40 is associated with poor prognosis. Our aim was to determine reference levels in healthy subjects. Methods: Plasma YKL-40 was determined in 3130 participants aged 20-80. years from the Danish general population, the Copenhagen City Heart Study. They had no known disease at time of blood sampling in 1991-1994 and remained healthy and alive during a 16-year follow-up period. In 644 participants, YKL-40 was measured again in samples taken 10. years after the first. Results: The median plasma YKL-40 was 40 μg/L (2.5-97.5% reference levels: 14-155) with no difference between sexes. YKL-40 increased exponentially with age. For age-adjusted reference levels, the YKL-40 percentile as a function of age in years and plasma YKL-40 in μg/L was derived: percentile = 100. /. (1. +. (YKL-40. ^-3).*(1.062. ^. age).*5000). In subjects with two YKL-40 measurements 10. years apart, the mean increase in YKL-40 was 1.5 μg/L/year (SE: 0.2), while the mean change in the calculated age percentile was minimal (-0.3; SE: 0.1). Conclusions: Plasma YKL-40 increases with age within and across healthy individuals from the general population. Age-stratified or age-adjusted reference levels are important when YKL-40 test results are evaluated.

AB - Background: Plasma YKL-40 is a new biomarker in patients with cancer and inflammatory diseases. High plasma YKL-40 is associated with poor prognosis. Our aim was to determine reference levels in healthy subjects. Methods: Plasma YKL-40 was determined in 3130 participants aged 20-80. years from the Danish general population, the Copenhagen City Heart Study. They had no known disease at time of blood sampling in 1991-1994 and remained healthy and alive during a 16-year follow-up period. In 644 participants, YKL-40 was measured again in samples taken 10. years after the first. Results: The median plasma YKL-40 was 40 μg/L (2.5-97.5% reference levels: 14-155) with no difference between sexes. YKL-40 increased exponentially with age. For age-adjusted reference levels, the YKL-40 percentile as a function of age in years and plasma YKL-40 in μg/L was derived: percentile = 100. /. (1. +. (YKL-40. ^-3).*(1.062. ^. age).*5000). In subjects with two YKL-40 measurements 10. years apart, the mean increase in YKL-40 was 1.5 μg/L/year (SE: 0.2), while the mean change in the calculated age percentile was minimal (-0.3; SE: 0.1). Conclusions: Plasma YKL-40 increases with age within and across healthy individuals from the general population. Age-stratified or age-adjusted reference levels are important when YKL-40 test results are evaluated.

U2 - 10.1016/j.cca.2011.01.022

DO - 10.1016/j.cca.2011.01.022

M3 - Journal article

SN - 0009-8981

VL - 412

SP - 709

EP - 712

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 9-10

ER -

Plasma YKL-40 levels in healthy subjects from the general population

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