Plasma lipid profiling of tissue-specific insulin resistance in human obesity

Birgitta W van der Kolk; Nicole Vogelzangs; Johan W E Jocken; Armand Valsesia; Thomas Hankemeier; Arne Astrup; Wim H M Saris; Ilja C W Arts; Marleen M J van Greevenbroek; Ellen E Blaak; DiOGenes consortium

doi:10.1038/s41366-018-0189-8

Plasma lipid profiling of tissue-specific insulin resistance in human obesity

Birgitta W van der Kolk, Nicole Vogelzangs, Johan W E Jocken, Armand Valsesia, Thomas Hankemeier, Arne Astrup, Wim H M Saris, Ilja C W Arts, Marleen M J van Greevenbroek, Ellen E Blaak, DiOGenes consortium

Obesity Research

13 Citations (Scopus)

Abstract

Background/Objectives: Obesity-associated insulin resistance (IR) may develop in multiple organs, representing different aetiologies towards cardiometabolic diseases. This study aimed to identify distinct plasma lipid profiles in overweight/obese individuals who show muscle-IR and/or liver-IR. Subjects/Methods: Baseline data of the European multicenter DiOGenes project were used (n = 640; 401 women, nondiabetic BMI: 27-45 kg/m²). Muscle insulin sensitivity index (MISI) and hepatic insulin resistance index (HIRI) were derived from a 5-point oral glucose tolerance test. The 140 plasma lipids were quantified by liquid chromatography–mass spectrometry. Linear mixed models were used to evaluate associations between MISI, HIRI and plasma lipids. Results: MISI was comparable between sexes while HIRI and triacylglycerol (TAG) levels were lower in women than in men. MISI was associated with higher lysophosphatidylcholine (LPC) levels (standardized (std)β = 0.126; FDR-p = 0.032). Sex interactions were observed for associations between HIRI, TAG and diacylglycerol (DAG) lipid classes. In women, but not in men, HIRI was associated with higher levels of TAG (44 out of 55 species) and both DAG species (stdβ: 0.139–0.313; FDR-p < 0.05), a lower odd-chain/even-chain TAG ratio (stdβ = −0.182; FDR-p = 0.005) and a lower very-long-chain/long-chain TAG ratio (stdβ = −0.156; FDR-p = 0.037). Conclusions: In overweight/obese individuals, muscle insulin sensitivity is associated with higher plasma LPC concentrations. Women have less hepatic IR and lower TAG than men. Nevertheless, hepatic IR is associated with higher plasma TAG and DAG concentrations and a lower abundance of odd-chain and very-long-chain TAG in women, but not in men. This suggests a more pronounced worsening of plasma lipid profile in women with the progression of hepatic IR.

Original language	English
Journal	International Journal of Obesity
Volume	43
Pages (from-to)	989-998
Number of pages	10
ISSN	0307-0565
DOIs	https://doi.org/10.1038/s41366-018-0189-8
Publication status	Published - 1 May 2019

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@article{02b75c3d521e412185b1168e518bf260,

title = "Plasma lipid profiling of tissue-specific insulin resistance in human obesity",

abstract = "Background/Objectives: Obesity-associated insulin resistance (IR) may develop in multiple organs, representing different aetiologies towards cardiometabolic diseases. This study aimed to identify distinct plasma lipid profiles in overweight/obese individuals who show muscle-IR and/or liver-IR. Subjects/Methods: Baseline data of the European multicenter DiOGenes project were used (n = 640; 401 women, nondiabetic BMI: 27-45 kg/m2). Muscle insulin sensitivity index (MISI) and hepatic insulin resistance index (HIRI) were derived from a 5-point oral glucose tolerance test. The 140 plasma lipids were quantified by liquid chromatography–mass spectrometry. Linear mixed models were used to evaluate associations between MISI, HIRI and plasma lipids. Results: MISI was comparable between sexes while HIRI and triacylglycerol (TAG) levels were lower in women than in men. MISI was associated with higher lysophosphatidylcholine (LPC) levels (standardized (std)β = 0.126; FDR-p = 0.032). Sex interactions were observed for associations between HIRI, TAG and diacylglycerol (DAG) lipid classes. In women, but not in men, HIRI was associated with higher levels of TAG (44 out of 55 species) and both DAG species (stdβ: 0.139–0.313; FDR-p < 0.05), a lower odd-chain/even-chain TAG ratio (stdβ = −0.182; FDR-p = 0.005) and a lower very-long-chain/long-chain TAG ratio (stdβ = −0.156; FDR-p = 0.037). Conclusions: In overweight/obese individuals, muscle insulin sensitivity is associated with higher plasma LPC concentrations. Women have less hepatic IR and lower TAG than men. Nevertheless, hepatic IR is associated with higher plasma TAG and DAG concentrations and a lower abundance of odd-chain and very-long-chain TAG in women, but not in men. This suggests a more pronounced worsening of plasma lipid profile in women with the progression of hepatic IR.",

author = "{van der Kolk}, {Birgitta W} and Nicole Vogelzangs and Jocken, {Johan W E} and Armand Valsesia and Thomas Hankemeier and Arne Astrup and Saris, {Wim H M} and Arts, {Ilja C W} and {van Greevenbroek}, {Marleen M J} and Blaak, {Ellen E} and {DiOGenes consortium}",

note = "CURIS 2019 NEXS 157",

year = "2019",

month = may,

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doi = "10.1038/s41366-018-0189-8",

language = "English",

volume = "43",

pages = "989--998",

journal = "International Journal of Obesity",

issn = "0307-0565",

publisher = "nature publishing group",

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TY - JOUR

T1 - Plasma lipid profiling of tissue-specific insulin resistance in human obesity

AU - van der Kolk, Birgitta W

AU - Vogelzangs, Nicole

AU - Jocken, Johan W E

AU - Valsesia, Armand

AU - Hankemeier, Thomas

AU - Astrup, Arne

AU - Saris, Wim H M

AU - Arts, Ilja C W

AU - van Greevenbroek, Marleen M J

AU - Blaak, Ellen E

AU - DiOGenes consortium

N1 - CURIS 2019 NEXS 157

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Background/Objectives: Obesity-associated insulin resistance (IR) may develop in multiple organs, representing different aetiologies towards cardiometabolic diseases. This study aimed to identify distinct plasma lipid profiles in overweight/obese individuals who show muscle-IR and/or liver-IR. Subjects/Methods: Baseline data of the European multicenter DiOGenes project were used (n = 640; 401 women, nondiabetic BMI: 27-45 kg/m2). Muscle insulin sensitivity index (MISI) and hepatic insulin resistance index (HIRI) were derived from a 5-point oral glucose tolerance test. The 140 plasma lipids were quantified by liquid chromatography–mass spectrometry. Linear mixed models were used to evaluate associations between MISI, HIRI and plasma lipids. Results: MISI was comparable between sexes while HIRI and triacylglycerol (TAG) levels were lower in women than in men. MISI was associated with higher lysophosphatidylcholine (LPC) levels (standardized (std)β = 0.126; FDR-p = 0.032). Sex interactions were observed for associations between HIRI, TAG and diacylglycerol (DAG) lipid classes. In women, but not in men, HIRI was associated with higher levels of TAG (44 out of 55 species) and both DAG species (stdβ: 0.139–0.313; FDR-p < 0.05), a lower odd-chain/even-chain TAG ratio (stdβ = −0.182; FDR-p = 0.005) and a lower very-long-chain/long-chain TAG ratio (stdβ = −0.156; FDR-p = 0.037). Conclusions: In overweight/obese individuals, muscle insulin sensitivity is associated with higher plasma LPC concentrations. Women have less hepatic IR and lower TAG than men. Nevertheless, hepatic IR is associated with higher plasma TAG and DAG concentrations and a lower abundance of odd-chain and very-long-chain TAG in women, but not in men. This suggests a more pronounced worsening of plasma lipid profile in women with the progression of hepatic IR.

AB - Background/Objectives: Obesity-associated insulin resistance (IR) may develop in multiple organs, representing different aetiologies towards cardiometabolic diseases. This study aimed to identify distinct plasma lipid profiles in overweight/obese individuals who show muscle-IR and/or liver-IR. Subjects/Methods: Baseline data of the European multicenter DiOGenes project were used (n = 640; 401 women, nondiabetic BMI: 27-45 kg/m2). Muscle insulin sensitivity index (MISI) and hepatic insulin resistance index (HIRI) were derived from a 5-point oral glucose tolerance test. The 140 plasma lipids were quantified by liquid chromatography–mass spectrometry. Linear mixed models were used to evaluate associations between MISI, HIRI and plasma lipids. Results: MISI was comparable between sexes while HIRI and triacylglycerol (TAG) levels were lower in women than in men. MISI was associated with higher lysophosphatidylcholine (LPC) levels (standardized (std)β = 0.126; FDR-p = 0.032). Sex interactions were observed for associations between HIRI, TAG and diacylglycerol (DAG) lipid classes. In women, but not in men, HIRI was associated with higher levels of TAG (44 out of 55 species) and both DAG species (stdβ: 0.139–0.313; FDR-p < 0.05), a lower odd-chain/even-chain TAG ratio (stdβ = −0.182; FDR-p = 0.005) and a lower very-long-chain/long-chain TAG ratio (stdβ = −0.156; FDR-p = 0.037). Conclusions: In overweight/obese individuals, muscle insulin sensitivity is associated with higher plasma LPC concentrations. Women have less hepatic IR and lower TAG than men. Nevertheless, hepatic IR is associated with higher plasma TAG and DAG concentrations and a lower abundance of odd-chain and very-long-chain TAG in women, but not in men. This suggests a more pronounced worsening of plasma lipid profile in women with the progression of hepatic IR.

U2 - 10.1038/s41366-018-0189-8

DO - 10.1038/s41366-018-0189-8

M3 - Journal article

C2 - 30242234

SN - 0307-0565

VL - 43

SP - 989

EP - 998

JO - International Journal of Obesity

JF - International Journal of Obesity

ER -

Plasma lipid profiling of tissue-specific insulin resistance in human obesity

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