TY - JOUR
T1 - Plasma cytokines in acute stroke
AU - Christensen, Hanne Krarup
AU - Boysen, Gudrun
AU - Christensen, Erik
AU - Johannesen, Helle Hjorth
AU - Bendtzen, Klaus
PY - 2002
Y1 - 2002
N2 - Goals: The aim of this study was to test the relations between plasma cytokines and the clinical characteristics, course, and risk factors in acute stroke. Patients and methods: The analysis was based on 179 patients with acute stroke included within 24 hours of stroke onset. On inclusion and 3 months later plasma levels of interleukin 1 β (IL-1β), tumor necrosis factor α (TNF-α), interleukin-1 receptor antagonist (IL-IRA), interleukin 6 (IL-6), interleukin 10 (IL-10), soluble tumor necrosis factor receptor I (sTNF-R1), and soluble tumor necrosis factor receptor 2 (sTNF-R2) were measured by enzyme-linked immunoassay (ELISA). Findings: The levels of most cytokines were significantly different in acute stroke from the levels 3 months later; but only IL-10 was positively associated with stroke severity. C-reactive protein and white blood cell count were positively associated with the cytokine response. Conclusions: We found a substantial overall cytokine reaction that reflected the stroke incident. However, these results do not, at present, suggest a potential for clinical use, as they do not seem to add to the information obtained from the clinical workup of the individual patient.
AB - Goals: The aim of this study was to test the relations between plasma cytokines and the clinical characteristics, course, and risk factors in acute stroke. Patients and methods: The analysis was based on 179 patients with acute stroke included within 24 hours of stroke onset. On inclusion and 3 months later plasma levels of interleukin 1 β (IL-1β), tumor necrosis factor α (TNF-α), interleukin-1 receptor antagonist (IL-IRA), interleukin 6 (IL-6), interleukin 10 (IL-10), soluble tumor necrosis factor receptor I (sTNF-R1), and soluble tumor necrosis factor receptor 2 (sTNF-R2) were measured by enzyme-linked immunoassay (ELISA). Findings: The levels of most cytokines were significantly different in acute stroke from the levels 3 months later; but only IL-10 was positively associated with stroke severity. C-reactive protein and white blood cell count were positively associated with the cytokine response. Conclusions: We found a substantial overall cytokine reaction that reflected the stroke incident. However, these results do not, at present, suggest a potential for clinical use, as they do not seem to add to the information obtained from the clinical workup of the individual patient.
U2 - 10.1053/jscd.2002.126688
DO - 10.1053/jscd.2002.126688
M3 - Journal article
C2 - 17903860
SN - 1052-3057
VL - 11
SP - 72
EP - 79
JO - Journal of Stroke & Cerebrovascular Diseases
JF - Journal of Stroke & Cerebrovascular Diseases
IS - 2
ER -