Plasma cytokines in acute stroke

Hanne Krarup Christensen, Gudrun Boysen, Erik Christensen, Helle Hjorth Johannesen, Klaus Bendtzen

    5 Citations (Scopus)

    Abstract

    Goals: The aim of this study was to test the relations between plasma cytokines and the clinical characteristics, course, and risk factors in acute stroke. Patients and methods: The analysis was based on 179 patients with acute stroke included within 24 hours of stroke onset. On inclusion and 3 months later plasma levels of interleukin 1 β (IL-1β), tumor necrosis factor α (TNF-α), interleukin-1 receptor antagonist (IL-IRA), interleukin 6 (IL-6), interleukin 10 (IL-10), soluble tumor necrosis factor receptor I (sTNF-R1), and soluble tumor necrosis factor receptor 2 (sTNF-R2) were measured by enzyme-linked immunoassay (ELISA). Findings: The levels of most cytokines were significantly different in acute stroke from the levels 3 months later; but only IL-10 was positively associated with stroke severity. C-reactive protein and white blood cell count were positively associated with the cytokine response. Conclusions: We found a substantial overall cytokine reaction that reflected the stroke incident. However, these results do not, at present, suggest a potential for clinical use, as they do not seem to add to the information obtained from the clinical workup of the individual patient.

    Original languageEnglish
    JournalJournal of Stroke & Cerebrovascular Diseases
    Volume11
    Issue number2
    Pages (from-to)72-9
    Number of pages8
    ISSN1052-3057
    DOIs
    Publication statusPublished - 2002

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