Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer

Cecilie Kyrø; Anja Olsen; Rikard Landberg; Guri Skeie; Steffen Loft; Per Åman; Max Leenders; Vincent K Dik; Peter D Siersema; Tobias Pischon; Jane Christensen; Kim Overvad; Marie-Christine Boutron-Ruault; Guy Fagherazzi; Vanessa Cottet; Tilman Kühn; Jenny Chang-Claude; Heiner Boeing; Antonia Trichopoulou; Christina Bamia; Dimitrios Trichopoulos; Domenico Palli; Vittorio Krogh; Rosario Tumino; Paolo Vineis; Salvatore Panico; Petra H Peeters; Elisabete Weiderpass; Toril Bakken; Lene Angell Åsli; Marcial Argüelles; Paula Jakszyn; María-José Sánchez; Pilar Amiano; José María Huerta; Aurelio Barricarte; Ingrid Ljuslinder; Richard Palmqvist; Kay-Tee Khaw; Nick Wareham; Timothy J Key; Ruth C Travis; Pietro Ferrari; Heinz Freisling; Mazda Jenab; Marc J Gunter; Neil Murphy; Eilo Riboli; Anne Tjønneland; H B as Bueno-de-Mesquita

doi:10.1093/jnci/djt352

Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer

Cecilie Kyrø, Anja Olsen, Rikard Landberg, Guri Skeie, Steffen Loft, Per Åman, Max Leenders, Vincent K Dik, Peter D Siersema, Tobias Pischon, Jane Christensen, Kim Overvad, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Vanessa Cottet, Tilman Kühn, Jenny Chang-Claude, Heiner Boeing, Antonia Trichopoulou, Christina BamiaDimitrios Trichopoulos, Domenico Palli, Vittorio Krogh, Rosario Tumino, Paolo Vineis, Salvatore Panico, Petra H Peeters, Elisabete Weiderpass, Toril Bakken, Lene Angell Åsli, Marcial Argüelles, Paula Jakszyn, María-José Sánchez, Pilar Amiano, José María Huerta, Aurelio Barricarte, Ingrid Ljuslinder, Richard Palmqvist, Kay-Tee Khaw, Nick Wareham, Timothy J Key, Ruth C Travis, Pietro Ferrari, Heinz Freisling, Mazda Jenab, Marc J Gunter, Neil Murphy, Eilo Riboli, Anne Tjønneland, H B as Bueno-de-Mesquita

Department of Public Health

53 Citations (Scopus)

Abstract

BACKGROUND: Few studies have investigated the association between whole-grain intake and colorectal cancer. Because whole-grain intake estimation might be prone to measurement errors, more objective measures (eg, biomarkers) could assist in investigating such associations.

METHODS: The association between alkylresorcinols, biomarkers of whole-grain rye and wheat intake, and colorectal cancer incidence were investigated using prediagnostic plasma samples from colorectal cancer case patients and matched control subjects nested within the European Prospective Investigation into Cancer and Nutrition. We included 1372 incident colorectal cancer case patients and 1372 individual matched control subjects and calculated the incidence rate ratios (IRRs) for overall and anatomical subsites of colorectal cancer using conditional logistic regression adjusted for potential confounders. Regional differences (Scandinavia, the Mediterranean, Central Europe) were also explored.

RESULTS: High plasma total alkylresorcinol concentration was associated with lower incidence of distal colon cancer; the adjusted incidence rate ratio of distal colon cancer for the highest vs lowest quartile of plasma total alkylresorcinols was 0.48 (95% confidence interval [CI] = 0.28 to 0.83). An inverse association between plasma total alkylresorcinol concentrations and colon cancer was found for Scandinavian participants (IRR per doubling = 0.83; 95% CI = 0.70 to 0.98). However, plasma total alkylresorcinol concentrations were not associated with overall colorectal cancer, proximal colon cancer, or rectal cancer. Plasma alkylresorcinols concentrations were associated with colon and distal colon cancer only in Central Europe and Scandinavia (ie, areas where alkylresorcinol levels were higher).

CONCLUSIONS: High concentrations of plasma alkylresorcinols were associated with a lower incidence of distal colon cancer but not with overall colorectal cancer, proximal colon cancer, and rectal cancer.

Original language	English
Article number	djt352
Journal	National Cancer Institute. Journal (Print)
Volume	106
Issue number	1
Pages (from-to)	1-9
Number of pages	9
ISSN	0027-8874
DOIs	https://doi.org/10.1093/jnci/djt352
Publication status	Published - Jan 2014

Keywords

Aged
Biological Markers
Body Mass Index
Case-Control Studies
Colorectal Neoplasms
Europe
Female
Food Habits
Humans
Incidence
Logistic Models
Male
Mediterranean Region
Middle Aged
Odds Ratio
Resorcinols
Risk Factors
Scandinavian and Nordic Countries
Secale cereale
Triticum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jnci/djt352

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Kyrø, C., Olsen, A., Landberg, R., Skeie, G., Loft, S., Åman, P., Leenders, M., Dik, V. K., Siersema, P. D., Pischon, T., Christensen, J., Overvad, K., Boutron-Ruault, M-C., Fagherazzi, G., Cottet, V., Kühn, T., Chang-Claude, J., Boeing, H., Trichopoulou, A., ... Bueno-de-Mesquita, H. B. A. (2014). Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer. National Cancer Institute. Journal (Print), 106(1), 1-9. [djt352]. https://doi.org/10.1093/jnci/djt352

Kyrø, C, Olsen, A, Landberg, R, Skeie, G, Loft, S, Åman, P, Leenders, M, Dik, VK, Siersema, PD, Pischon, T, Christensen, J, Overvad, K, Boutron-Ruault, M-C, Fagherazzi, G, Cottet, V, Kühn, T, Chang-Claude, J, Boeing, H, Trichopoulou, A, Bamia, C, Trichopoulos, D, Palli, D, Krogh, V, Tumino, R, Vineis, P, Panico, S, Peeters, PH, Weiderpass, E, Bakken, T, Åsli, LA, Argüelles, M, Jakszyn, P, Sánchez, M-J, Amiano, P, Huerta, JM, Barricarte, A, Ljuslinder, I, Palmqvist, R, Khaw, K-T, Wareham, N, Key, TJ, Travis, RC, Ferrari, P, Freisling, H, Jenab, M, Gunter, MJ, Murphy, N, Riboli, E, Tjønneland, A & Bueno-de-Mesquita, HBA 2014, 'Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer', National Cancer Institute. Journal (Print), vol. 106, no. 1, djt352, pp. 1-9. https://doi.org/10.1093/jnci/djt352

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abstract = "BACKGROUND: Few studies have investigated the association between whole-grain intake and colorectal cancer. Because whole-grain intake estimation might be prone to measurement errors, more objective measures (eg, biomarkers) could assist in investigating such associations.METHODS: The association between alkylresorcinols, biomarkers of whole-grain rye and wheat intake, and colorectal cancer incidence were investigated using prediagnostic plasma samples from colorectal cancer case patients and matched control subjects nested within the European Prospective Investigation into Cancer and Nutrition. We included 1372 incident colorectal cancer case patients and 1372 individual matched control subjects and calculated the incidence rate ratios (IRRs) for overall and anatomical subsites of colorectal cancer using conditional logistic regression adjusted for potential confounders. Regional differences (Scandinavia, the Mediterranean, Central Europe) were also explored.RESULTS: High plasma total alkylresorcinol concentration was associated with lower incidence of distal colon cancer; the adjusted incidence rate ratio of distal colon cancer for the highest vs lowest quartile of plasma total alkylresorcinols was 0.48 (95% confidence interval [CI] = 0.28 to 0.83). An inverse association between plasma total alkylresorcinol concentrations and colon cancer was found for Scandinavian participants (IRR per doubling = 0.83; 95% CI = 0.70 to 0.98). However, plasma total alkylresorcinol concentrations were not associated with overall colorectal cancer, proximal colon cancer, or rectal cancer. Plasma alkylresorcinols concentrations were associated with colon and distal colon cancer only in Central Europe and Scandinavia (ie, areas where alkylresorcinol levels were higher).CONCLUSIONS: High concentrations of plasma alkylresorcinols were associated with a lower incidence of distal colon cancer but not with overall colorectal cancer, proximal colon cancer, and rectal cancer.",

keywords = "Aged, Biological Markers, Body Mass Index, Case-Control Studies, Colorectal Neoplasms, Europe, Female, Food Habits, Humans, Incidence, Logistic Models, Male, Mediterranean Region, Middle Aged, Odds Ratio, Resorcinols, Risk Factors, Scandinavian and Nordic Countries, Secale cereale, Triticum",

author = "Cecilie Kyr{\o} and Anja Olsen and Rikard Landberg and Guri Skeie and Steffen Loft and Per {\AA}man and Max Leenders and Dik, {Vincent K} and Siersema, {Peter D} and Tobias Pischon and Jane Christensen and Kim Overvad and Marie-Christine Boutron-Ruault and Guy Fagherazzi and Vanessa Cottet and Tilman K{\"u}hn and Jenny Chang-Claude and Heiner Boeing and Antonia Trichopoulou and Christina Bamia and Dimitrios Trichopoulos and Domenico Palli and Vittorio Krogh and Rosario Tumino and Paolo Vineis and Salvatore Panico and Peeters, {Petra H} and Elisabete Weiderpass and Toril Bakken and {\AA}sli, {Lene Angell} and Marcial Arg{\"u}elles and Paula Jakszyn and Mar{\'i}a-Jos{\'e} S{\'a}nchez and Pilar Amiano and Huerta, {Jos{\'e} Mar{\'i}a} and Aurelio Barricarte and Ingrid Ljuslinder and Richard Palmqvist and Kay-Tee Khaw and Nick Wareham and Key, {Timothy J} and Travis, {Ruth C} and Pietro Ferrari and Heinz Freisling and Mazda Jenab and Gunter, {Marc J} and Neil Murphy and Eilo Riboli and Anne Tj{\o}nneland and Bueno-de-Mesquita, {H B as}",

year = "2014",

month = jan,

doi = "10.1093/jnci/djt352",

language = "English",

volume = "106",

pages = "1--9",

journal = "National Cancer Institute. Journal (Print)",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "1",

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TY - JOUR

T1 - Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer

AU - Kyrø, Cecilie

AU - Olsen, Anja

AU - Landberg, Rikard

AU - Skeie, Guri

AU - Loft, Steffen

AU - Åman, Per

AU - Leenders, Max

AU - Dik, Vincent K

AU - Siersema, Peter D

AU - Pischon, Tobias

AU - Christensen, Jane

AU - Overvad, Kim

AU - Boutron-Ruault, Marie-Christine

AU - Fagherazzi, Guy

AU - Cottet, Vanessa

AU - Kühn, Tilman

AU - Chang-Claude, Jenny

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Krogh, Vittorio

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Panico, Salvatore

AU - Peeters, Petra H

AU - Weiderpass, Elisabete

AU - Bakken, Toril

AU - Åsli, Lene Angell

AU - Argüelles, Marcial

AU - Jakszyn, Paula

AU - Sánchez, María-José

AU - Amiano, Pilar

AU - Huerta, José María

AU - Barricarte, Aurelio

AU - Ljuslinder, Ingrid

AU - Palmqvist, Richard

AU - Khaw, Kay-Tee

AU - Wareham, Nick

AU - Key, Timothy J

AU - Travis, Ruth C

AU - Ferrari, Pietro

AU - Freisling, Heinz

AU - Jenab, Mazda

AU - Gunter, Marc J

AU - Murphy, Neil

AU - Riboli, Eilo

AU - Tjønneland, Anne

AU - Bueno-de-Mesquita, H B as

PY - 2014/1

Y1 - 2014/1

N2 - BACKGROUND: Few studies have investigated the association between whole-grain intake and colorectal cancer. Because whole-grain intake estimation might be prone to measurement errors, more objective measures (eg, biomarkers) could assist in investigating such associations.METHODS: The association between alkylresorcinols, biomarkers of whole-grain rye and wheat intake, and colorectal cancer incidence were investigated using prediagnostic plasma samples from colorectal cancer case patients and matched control subjects nested within the European Prospective Investigation into Cancer and Nutrition. We included 1372 incident colorectal cancer case patients and 1372 individual matched control subjects and calculated the incidence rate ratios (IRRs) for overall and anatomical subsites of colorectal cancer using conditional logistic regression adjusted for potential confounders. Regional differences (Scandinavia, the Mediterranean, Central Europe) were also explored.RESULTS: High plasma total alkylresorcinol concentration was associated with lower incidence of distal colon cancer; the adjusted incidence rate ratio of distal colon cancer for the highest vs lowest quartile of plasma total alkylresorcinols was 0.48 (95% confidence interval [CI] = 0.28 to 0.83). An inverse association between plasma total alkylresorcinol concentrations and colon cancer was found for Scandinavian participants (IRR per doubling = 0.83; 95% CI = 0.70 to 0.98). However, plasma total alkylresorcinol concentrations were not associated with overall colorectal cancer, proximal colon cancer, or rectal cancer. Plasma alkylresorcinols concentrations were associated with colon and distal colon cancer only in Central Europe and Scandinavia (ie, areas where alkylresorcinol levels were higher).CONCLUSIONS: High concentrations of plasma alkylresorcinols were associated with a lower incidence of distal colon cancer but not with overall colorectal cancer, proximal colon cancer, and rectal cancer.

AB - BACKGROUND: Few studies have investigated the association between whole-grain intake and colorectal cancer. Because whole-grain intake estimation might be prone to measurement errors, more objective measures (eg, biomarkers) could assist in investigating such associations.METHODS: The association between alkylresorcinols, biomarkers of whole-grain rye and wheat intake, and colorectal cancer incidence were investigated using prediagnostic plasma samples from colorectal cancer case patients and matched control subjects nested within the European Prospective Investigation into Cancer and Nutrition. We included 1372 incident colorectal cancer case patients and 1372 individual matched control subjects and calculated the incidence rate ratios (IRRs) for overall and anatomical subsites of colorectal cancer using conditional logistic regression adjusted for potential confounders. Regional differences (Scandinavia, the Mediterranean, Central Europe) were also explored.RESULTS: High plasma total alkylresorcinol concentration was associated with lower incidence of distal colon cancer; the adjusted incidence rate ratio of distal colon cancer for the highest vs lowest quartile of plasma total alkylresorcinols was 0.48 (95% confidence interval [CI] = 0.28 to 0.83). An inverse association between plasma total alkylresorcinol concentrations and colon cancer was found for Scandinavian participants (IRR per doubling = 0.83; 95% CI = 0.70 to 0.98). However, plasma total alkylresorcinol concentrations were not associated with overall colorectal cancer, proximal colon cancer, or rectal cancer. Plasma alkylresorcinols concentrations were associated with colon and distal colon cancer only in Central Europe and Scandinavia (ie, areas where alkylresorcinol levels were higher).CONCLUSIONS: High concentrations of plasma alkylresorcinols were associated with a lower incidence of distal colon cancer but not with overall colorectal cancer, proximal colon cancer, and rectal cancer.

KW - Aged

KW - Biological Markers

KW - Body Mass Index

KW - Case-Control Studies

KW - Colorectal Neoplasms

KW - Europe

KW - Female

KW - Food Habits

KW - Humans

KW - Incidence

KW - Logistic Models

KW - Male

KW - Mediterranean Region

KW - Middle Aged

KW - Odds Ratio

KW - Resorcinols

KW - Risk Factors

KW - Scandinavian and Nordic Countries

KW - Secale cereale

KW - Triticum

U2 - 10.1093/jnci/djt352

DO - 10.1093/jnci/djt352

M3 - Journal article

C2 - 24317181

SN - 0027-8874

VL - 106

SP - 1

EP - 9

JO - National Cancer Institute. Journal (Print)

JF - National Cancer Institute. Journal (Print)

IS - 1

M1 - djt352

ER -

Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and incidence of colorectal cancer

Abstract

Keywords

UN SDGs

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