Planar SERS nanostructures with stochastic silver ring morphology for biosensor chips

Anna Semenova; Eugene Goodilin; Nadezda Brazhe; Vladimir Ivanov; Alexander Baranchikov; Vasiliy Lebedev; Anastasia Goldt; Olga Sosnovtseva; Sergey Savilov; Alexander Egorov; Alexey Brazhe; Evgeniya Parshina; Oxana  Luneva; Georgy Maksimov; Yury Tretyakov

doi:10.1039/c2jm34686a

Planar SERS nanostructures with stochastic silver ring morphology for biosensor chips

Anna Semenova, Eugene Goodilin, Nadezda Brazhe, Vladimir Ivanov, Alexander Baranchikov, Vasiliy Lebedev, Anastasia Goldt, Olga Sosnovtseva, Sergey Savilov, Alexander Egorov, Alexey Brazhe, Evgeniya Parshina, Oxana Luneva, Georgy Maksimov, Yury Tretyakov

53 Citations (Scopus)

Abstract

Surface-enhanced Raman spectroscopy (SERS) of living cells has rapidly become a powerful trend in biomedical diagnostics. It is a common belief that highly ordered, artificially engineered substrates are the best future decision in this field. This paper, however, describes an alternative successful solution, a new effortless chemical approach to the design of nanostructured silver and heterometallic continuous coatings with a stochastic "coffee ring" morphology. The coatings are formed from an ultrasonic mist of aqueous diamminesilver hydroxide, free of reducing agents and nonvolatile pollutants, under mild conditions, at about 200-270 °C in air. They consist of 30-100 micrometer wide and 100-400 nm high silver rings composed, in turn, of a porous silver matrix with 10-50 nm silver grains decorating the sponge. This hierarchic structure originates from ultrasonic droplet evaporation, contact-line motion, silver(i) oxide decomposition and evolution of a growing ensemble of silver rings. The fabricated substrates are a remarkable example of a new scalable and low cost material suitable for SERS analyses of living cells. They evoke no hemolysis and reduce erythrocyte lateral mobility due to suitable "coffee ring" sizes and a tight contact with the silver nanostructure. A high SERS enhancement, characteristic of pure silver rings, made it possible to record Raman scattering spectra from submembrane hemoglobin in its natural cellular environment inside single living erythrocytes, thus making the substrates promising for various biosensor chips.

Original language	English
Journal	Journal of Materials Chemistry
Volume	22
Issue number	47
Pages (from-to)	24530
Number of pages	14
ISSN	0959-9428
DOIs	https://doi.org/10.1039/c2jm34686a
Publication status	Published - 21 Dec 2012

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Semenova, A., Goodilin, E., Brazhe, N., Ivanov, V., Baranchikov, A., Lebedev, V., Goldt, A., Sosnovtseva, O., Savilov, S., Egorov, A., Brazhe, A., Parshina, E., Luneva, O., Maksimov, G., & Tretyakov, Y. (2012). Planar SERS nanostructures with stochastic silver ring morphology for biosensor chips. Journal of Materials Chemistry, 22(47), 24530. https://doi.org/10.1039/c2jm34686a

Semenova, A, Goodilin, E, Brazhe, N, Ivanov, V, Baranchikov, A, Lebedev, V, Goldt, A, Sosnovtseva, O, Savilov, S, Egorov, A, Brazhe, A, Parshina, E, Luneva, O, Maksimov, G & Tretyakov, Y 2012, 'Planar SERS nanostructures with stochastic silver ring morphology for biosensor chips', Journal of Materials Chemistry, vol. 22, no. 47, pp. 24530. https://doi.org/10.1039/c2jm34686a

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title = "Planar SERS nanostructures with stochastic silver ring morphology for biosensor chips",

abstract = "Surface-enhanced Raman spectroscopy (SERS) of living cells has rapidly become a powerful trend in biomedical diagnostics. It is a common belief that highly ordered, artificially engineered substrates are the best future decision in this field. This paper, however, describes an alternative successful solution, a new effortless chemical approach to the design of nanostructured silver and heterometallic continuous coatings with a stochastic {"}coffee ring{"} morphology. The coatings are formed from an ultrasonic mist of aqueous diamminesilver hydroxide, free of reducing agents and nonvolatile pollutants, under mild conditions, at about 200-270 °C in air. They consist of 30-100 micrometer wide and 100-400 nm high silver rings composed, in turn, of a porous silver matrix with 10-50 nm silver grains decorating the sponge. This hierarchic structure originates from ultrasonic droplet evaporation, contact-line motion, silver(i) oxide decomposition and evolution of a growing ensemble of silver rings. The fabricated substrates are a remarkable example of a new scalable and low cost material suitable for SERS analyses of living cells. They evoke no hemolysis and reduce erythrocyte lateral mobility due to suitable {"}coffee ring{"} sizes and a tight contact with the silver nanostructure. A high SERS enhancement, characteristic of pure silver rings, made it possible to record Raman scattering spectra from submembrane hemoglobin in its natural cellular environment inside single living erythrocytes, thus making the substrates promising for various biosensor chips.",

author = "Anna Semenova and Eugene Goodilin and Nadezda Brazhe and Vladimir Ivanov and Alexander Baranchikov and Vasiliy Lebedev and Anastasia Goldt and Olga Sosnovtseva and Sergey Savilov and Alexander Egorov and Alexey Brazhe and Evgeniya Parshina and Oxana Luneva and Georgy Maksimov and Yury Tretyakov",

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AU - Goodilin, Eugene

AU - Brazhe, Nadezda

AU - Ivanov, Vladimir

AU - Baranchikov, Alexander

AU - Lebedev, Vasiliy

AU - Goldt, Anastasia

AU - Sosnovtseva, Olga

AU - Savilov, Sergey

AU - Egorov, Alexander

AU - Brazhe, Alexey

AU - Parshina, Evgeniya

AU - Luneva, Oxana

AU - Maksimov, Georgy

AU - Tretyakov, Yury

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N2 - Surface-enhanced Raman spectroscopy (SERS) of living cells has rapidly become a powerful trend in biomedical diagnostics. It is a common belief that highly ordered, artificially engineered substrates are the best future decision in this field. This paper, however, describes an alternative successful solution, a new effortless chemical approach to the design of nanostructured silver and heterometallic continuous coatings with a stochastic "coffee ring" morphology. The coatings are formed from an ultrasonic mist of aqueous diamminesilver hydroxide, free of reducing agents and nonvolatile pollutants, under mild conditions, at about 200-270 °C in air. They consist of 30-100 micrometer wide and 100-400 nm high silver rings composed, in turn, of a porous silver matrix with 10-50 nm silver grains decorating the sponge. This hierarchic structure originates from ultrasonic droplet evaporation, contact-line motion, silver(i) oxide decomposition and evolution of a growing ensemble of silver rings. The fabricated substrates are a remarkable example of a new scalable and low cost material suitable for SERS analyses of living cells. They evoke no hemolysis and reduce erythrocyte lateral mobility due to suitable "coffee ring" sizes and a tight contact with the silver nanostructure. A high SERS enhancement, characteristic of pure silver rings, made it possible to record Raman scattering spectra from submembrane hemoglobin in its natural cellular environment inside single living erythrocytes, thus making the substrates promising for various biosensor chips.

AB - Surface-enhanced Raman spectroscopy (SERS) of living cells has rapidly become a powerful trend in biomedical diagnostics. It is a common belief that highly ordered, artificially engineered substrates are the best future decision in this field. This paper, however, describes an alternative successful solution, a new effortless chemical approach to the design of nanostructured silver and heterometallic continuous coatings with a stochastic "coffee ring" morphology. The coatings are formed from an ultrasonic mist of aqueous diamminesilver hydroxide, free of reducing agents and nonvolatile pollutants, under mild conditions, at about 200-270 °C in air. They consist of 30-100 micrometer wide and 100-400 nm high silver rings composed, in turn, of a porous silver matrix with 10-50 nm silver grains decorating the sponge. This hierarchic structure originates from ultrasonic droplet evaporation, contact-line motion, silver(i) oxide decomposition and evolution of a growing ensemble of silver rings. The fabricated substrates are a remarkable example of a new scalable and low cost material suitable for SERS analyses of living cells. They evoke no hemolysis and reduce erythrocyte lateral mobility due to suitable "coffee ring" sizes and a tight contact with the silver nanostructure. A high SERS enhancement, characteristic of pure silver rings, made it possible to record Raman scattering spectra from submembrane hemoglobin in its natural cellular environment inside single living erythrocytes, thus making the substrates promising for various biosensor chips.

U2 - 10.1039/c2jm34686a

DO - 10.1039/c2jm34686a

M3 - Journal article

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JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 47

ER -

Planar SERS nanostructures with stochastic silver ring morphology for biosensor chips

Abstract

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