Abstract
In recent years, the search for genetic determinants of type 2 diabetes has resulted in identification of numerous type 2 diabetes-associated loci as well as a number of loci associating with related prediabetic traits. These findings have illuminated new biological pathways contributing to the pathogenesis of type 2 diabetes, but have also demonstrated that type 2 diabetes is an extremely heterogeneous disease with limited overlap between genetic loci associating with type 2 diabetes and loci associating with diabetes-related traits, such as body mass index, fasting glucose levels, and fasting insulin levels. Combined, these loci only account for a fraction of the observed familial clustering of type 2 diabetes and only up to about 10 % of the variation in prediabetic quantitative traits. Improved methods are needed to dig deeper into a biological understanding of the pathophysiology of type 2 diabetes.
| Original language | English |
|---|---|
| Title of host publication | The Genetics of Type 2 Diabetes and Related Traits : Biology, Physiology and Translation |
| Number of pages | 15 |
| Publisher | Springer |
| Publication date | 2016 |
| Pages | 207-221 |
| Chapter | 9 |
| ISBN (Print) | 978-3-319-01573-6 |
| ISBN (Electronic) | 978-3-319-01574-3 |
| DOIs | |
| Publication status | Published - 2016 |
