Physical Activity Prevents Progression for Cognitive Impairment and Vascular Dementia: Results From the LADIS (Leukoaraiosis and Disability) Study

Ana Verdelho; Sofia Madureira; José M Ferro; Hansjörg Baezner; Christian Blahak; Anna Poggesi; Michael Hennerici; Leonardo Pantoni; Franz Fazekas; Philip Scheltens; Gunhild Waldemar; Anders Wallin; Timo Erkinjuntti; Domenico Inzitari; on behalf of the LADIS Study

doi:10.1161/STROKEAHA.112.661793

Physical Activity Prevents Progression for Cognitive Impairment and Vascular Dementia: Results From the LADIS (Leukoaraiosis and Disability) Study

Ana Verdelho, Sofia Madureira, José M Ferro, Hansjörg Baezner, Christian Blahak, Anna Poggesi, Michael Hennerici, Leonardo Pantoni, Franz Fazekas, Philip Scheltens, Gunhild Waldemar, Anders Wallin, Timo Erkinjuntti, Domenico Inzitari, on behalf of the LADIS Study

65 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: We aimed to study if physical activity could interfere with progression for cognitive impairment and dementia in older people with white matter changes living independently. METHODS: The LADIS (Leukoaraiosis and Disability) prospective multinational European study evaluates the impact of white matter changes on the transition of independent elderly subjects into disability. Subjects were evaluated yearly during 3 years with a comprehensive clinical protocol and cognitive assessment with classification of cognitive impairment and dementia according to usual clinical criteria. Physical activity was recorded during the clinical interview. MRI was performed at entry and at the end of the study. RESULTS: Six hundred thirty-nine subjects were included (74.1±5 years old, 55% women, 9.6±3.8 years of schooling, 64% physically active). At the end of follow-up, 90 patients had dementia (vascular dementia, 54; Alzheimer disease with vascular component, 34; frontotemporal dementia, 2), and 147 had cognitive impairment not dementia. Using Cox regression analysis, physical activity reduced the risk of cognitive impairment (dementia and not dementia: β=-0.45, P=0.002; hazard ratio, 0.64; 95% CI, 0.48-0.85), dementia (β=-0.49, P=0.043; hazard ratio, 0.61; 95% CI, 0.38-0.98), and vascular dementia (β=-0.86, P=0.008; hazard ratio, 0.42; 95% CI, 0.22-0.80), independent of age, education, white matter change severity, medial temporal atrophy, previous and incident stroke, and diabetes. CONCLUSIONS: Physical activity reduces the risk of cognitive impairment, mainly vascular dementia, in older people living independently.

Original language	English
Journal	Stroke
Volume	43
Issue number	12
Pages (from-to)	3331-3335
Number of pages	5
ISSN	0039-2499
DOIs	https://doi.org/10.1161/STROKEAHA.112.661793
Publication status	Published - Dec 2012

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10.1161/STROKEAHA.112.661793

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Verdelho, A., Madureira, S., Ferro, J. M., Baezner, H., Blahak, C., Poggesi, A., Hennerici, M., Pantoni, L., Fazekas, F., Scheltens, P., Waldemar, G., Wallin, A., Erkinjuntti, T., Inzitari, D., & on behalf of the LADIS Study (2012). Physical Activity Prevents Progression for Cognitive Impairment and Vascular Dementia: Results From the LADIS (Leukoaraiosis and Disability) Study. Stroke, 43(12), 3331-3335. https://doi.org/10.1161/STROKEAHA.112.661793

Verdelho, A, Madureira, S, Ferro, JM, Baezner, H, Blahak, C, Poggesi, A, Hennerici, M, Pantoni, L, Fazekas, F, Scheltens, P, Waldemar, G, Wallin, A, Erkinjuntti, T, Inzitari, D & on behalf of the LADIS Study 2012, 'Physical Activity Prevents Progression for Cognitive Impairment and Vascular Dementia: Results From the LADIS (Leukoaraiosis and Disability) Study', Stroke, vol. 43, no. 12, pp. 3331-3335. https://doi.org/10.1161/STROKEAHA.112.661793

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title = "Physical Activity Prevents Progression for Cognitive Impairment and Vascular Dementia: Results From the LADIS (Leukoaraiosis and Disability) Study",

abstract = "BACKGROUND AND PURPOSE: We aimed to study if physical activity could interfere with progression for cognitive impairment and dementia in older people with white matter changes living independently. METHODS: The LADIS (Leukoaraiosis and Disability) prospective multinational European study evaluates the impact of white matter changes on the transition of independent elderly subjects into disability. Subjects were evaluated yearly during 3 years with a comprehensive clinical protocol and cognitive assessment with classification of cognitive impairment and dementia according to usual clinical criteria. Physical activity was recorded during the clinical interview. MRI was performed at entry and at the end of the study. RESULTS: Six hundred thirty-nine subjects were included (74.1±5 years old, 55% women, 9.6±3.8 years of schooling, 64% physically active). At the end of follow-up, 90 patients had dementia (vascular dementia, 54; Alzheimer disease with vascular component, 34; frontotemporal dementia, 2), and 147 had cognitive impairment not dementia. Using Cox regression analysis, physical activity reduced the risk of cognitive impairment (dementia and not dementia: β=-0.45, P=0.002; hazard ratio, 0.64; 95% CI, 0.48-0.85), dementia (β=-0.49, P=0.043; hazard ratio, 0.61; 95% CI, 0.38-0.98), and vascular dementia (β=-0.86, P=0.008; hazard ratio, 0.42; 95% CI, 0.22-0.80), independent of age, education, white matter change severity, medial temporal atrophy, previous and incident stroke, and diabetes. CONCLUSIONS: Physical activity reduces the risk of cognitive impairment, mainly vascular dementia, in older people living independently.",

author = "Ana Verdelho and Sofia Madureira and Ferro, {Jos{\'e} M} and Hansj{\"o}rg Baezner and Christian Blahak and Anna Poggesi and Michael Hennerici and Leonardo Pantoni and Franz Fazekas and Philip Scheltens and Gunhild Waldemar and Anders Wallin and Timo Erkinjuntti and Domenico Inzitari and Gunhild Waldemar",

year = "2012",

month = dec,

doi = "10.1161/STROKEAHA.112.661793",

language = "English",

volume = "43",

pages = "3331--3335",

journal = "Stroke",

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TY - JOUR

T1 - Physical Activity Prevents Progression for Cognitive Impairment and Vascular Dementia

T2 - Results From the LADIS (Leukoaraiosis and Disability) Study

AU - Verdelho, Ana

AU - Madureira, Sofia

AU - Ferro, José M

AU - Baezner, Hansjörg

AU - Blahak, Christian

AU - Poggesi, Anna

AU - Hennerici, Michael

AU - Pantoni, Leonardo

AU - Fazekas, Franz

AU - Scheltens, Philip

AU - Waldemar, Gunhild

AU - Wallin, Anders

AU - Erkinjuntti, Timo

AU - Inzitari, Domenico

AU - on behalf of the LADIS Study

PY - 2012/12

Y1 - 2012/12

N2 - BACKGROUND AND PURPOSE: We aimed to study if physical activity could interfere with progression for cognitive impairment and dementia in older people with white matter changes living independently. METHODS: The LADIS (Leukoaraiosis and Disability) prospective multinational European study evaluates the impact of white matter changes on the transition of independent elderly subjects into disability. Subjects were evaluated yearly during 3 years with a comprehensive clinical protocol and cognitive assessment with classification of cognitive impairment and dementia according to usual clinical criteria. Physical activity was recorded during the clinical interview. MRI was performed at entry and at the end of the study. RESULTS: Six hundred thirty-nine subjects were included (74.1±5 years old, 55% women, 9.6±3.8 years of schooling, 64% physically active). At the end of follow-up, 90 patients had dementia (vascular dementia, 54; Alzheimer disease with vascular component, 34; frontotemporal dementia, 2), and 147 had cognitive impairment not dementia. Using Cox regression analysis, physical activity reduced the risk of cognitive impairment (dementia and not dementia: β=-0.45, P=0.002; hazard ratio, 0.64; 95% CI, 0.48-0.85), dementia (β=-0.49, P=0.043; hazard ratio, 0.61; 95% CI, 0.38-0.98), and vascular dementia (β=-0.86, P=0.008; hazard ratio, 0.42; 95% CI, 0.22-0.80), independent of age, education, white matter change severity, medial temporal atrophy, previous and incident stroke, and diabetes. CONCLUSIONS: Physical activity reduces the risk of cognitive impairment, mainly vascular dementia, in older people living independently.

AB - BACKGROUND AND PURPOSE: We aimed to study if physical activity could interfere with progression for cognitive impairment and dementia in older people with white matter changes living independently. METHODS: The LADIS (Leukoaraiosis and Disability) prospective multinational European study evaluates the impact of white matter changes on the transition of independent elderly subjects into disability. Subjects were evaluated yearly during 3 years with a comprehensive clinical protocol and cognitive assessment with classification of cognitive impairment and dementia according to usual clinical criteria. Physical activity was recorded during the clinical interview. MRI was performed at entry and at the end of the study. RESULTS: Six hundred thirty-nine subjects were included (74.1±5 years old, 55% women, 9.6±3.8 years of schooling, 64% physically active). At the end of follow-up, 90 patients had dementia (vascular dementia, 54; Alzheimer disease with vascular component, 34; frontotemporal dementia, 2), and 147 had cognitive impairment not dementia. Using Cox regression analysis, physical activity reduced the risk of cognitive impairment (dementia and not dementia: β=-0.45, P=0.002; hazard ratio, 0.64; 95% CI, 0.48-0.85), dementia (β=-0.49, P=0.043; hazard ratio, 0.61; 95% CI, 0.38-0.98), and vascular dementia (β=-0.86, P=0.008; hazard ratio, 0.42; 95% CI, 0.22-0.80), independent of age, education, white matter change severity, medial temporal atrophy, previous and incident stroke, and diabetes. CONCLUSIONS: Physical activity reduces the risk of cognitive impairment, mainly vascular dementia, in older people living independently.

U2 - 10.1161/STROKEAHA.112.661793

DO - 10.1161/STROKEAHA.112.661793

M3 - Journal article

C2 - 23117721

SN - 0039-2499

VL - 43

SP - 3331

EP - 3335

JO - Stroke

JF - Stroke

IS - 12

ER -

Physical Activity Prevents Progression for Cognitive Impairment and Vascular Dementia: Results From the LADIS (Leukoaraiosis and Disability) Study

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