Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study

Kristian Steen Frederiksen; Ana Verdelho; Sofia Madureira; Hansjörg Bäzner; John T O'Brien; Franz Fazekas; Philip Scheltens; Reinhold Schmidt; Anders Wallin; Lars-Olof Wahlund; Timo Erkinjunttii; Anna Poggesi; Leonardo Pantoni; Domenico Inzitari; Gunhild Waldemar; LADIS Study

doi:10.1002/gps.4220

Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study

Kristian Steen Frederiksen, Ana Verdelho, Sofia Madureira, Hansjörg Bäzner, John T O'Brien, Franz Fazekas, Philip Scheltens, Reinhold Schmidt, Anders Wallin, Lars-Olof Wahlund, Timo Erkinjunttii, Anna Poggesi, Leonardo Pantoni, Domenico Inzitari, Gunhild Waldemar, LADIS Study

Department of Clinical Medicine

36 Citations (Scopus)

Abstract

OBJECTIVES: Physical activity reduces the risk of cognitive decline but may affect cognitive domains differently. We examined whether physical activity modifies processing speed, executive function and memory in a population of non-dementia elderly subjects with age-related white matter changes (ARWMC).

METHODS: Data from the Leukoaraiosis And DISability (LADIS) study, a multicenter, European prospective cohort study aimed at examining the role of ARWMC in transition to disability, was used. Subjects in the LADIS study were clinically assessed yearly for 3 years including MRI at baseline and 3-year follow-up. Physical activity was assessed at baseline, and cognitive compound scores at baseline and 3-year assessment were used.

RESULTS: Two-hundred-eighty-two subjects (age, y (mean (SD)): 73.1 (± 5.1); gender (f/m): 164/118); MMSE (mean (SD)): 28.3 (± 1.7)) who had not progressed to MCI or dementia, were included. Multiple variable linear regression analysis with baseline MMSE, education, gender, age, stroke, diabetes and ARWMC rating as covariates revealed that physical activity was associated with better scores at baseline and 3-year follow-up for executive function (baseline: β: 0.39, 95% CI: 0.13-0.90, p = 0.008; follow-up: β: 0.24, 95% CI: 0.10-0.38, p = 0.001) and processing speed (baseline: β: 0.48, 95% CI: 0.14-0.89, p = 0.005; follow-up: β: 0.15, 95% CI: 0.02-0.29, p = 0.02) but not memory. When including baseline cognitive score as a covariate in the analysis of 3-year follow-up scores, executive function remained significant (β: 0.11, 95% CI: 0-0.22, p = 0.04).

CONCLUSION: Our findings confirm previous findings of a positive effect of physical activity on cognitive functions in elderly subjects, and further extends these by showing that the association is also present in patients with ARWMC.

Original language	English
Journal	International Journal of Geriatric Psychiatry
Volume	30
Issue number	7
Pages (from-to)	744-50
Number of pages	7
ISSN	0885-6230
DOIs	https://doi.org/10.1002/gps.4220
Publication status	Published - 1 Jul 2015

Keywords

Activities of Daily Living
Aged
Aged, 80 and over
Brain
Cognition
Dementia
Executive Function
Female
Humans
Magnetic Resonance Imaging
Male
Memory, Short-Term
Middle Aged
Mild Cognitive Impairment
Motor Activity
Neuropsychological Tests
Prospective Studies
Regression Analysis
White Matter

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/gps.4220

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Frederiksen, K. S., Verdelho, A., Madureira, S., Bäzner, H., O'Brien, J. T., Fazekas, F., Scheltens, P., Schmidt, R., Wallin, A., Wahlund, L-O., Erkinjunttii, T., Poggesi, A., Pantoni, L., Inzitari, D., Waldemar, G., & LADIS Study (2015). Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study. International Journal of Geriatric Psychiatry, 30(7), 744-50. https://doi.org/10.1002/gps.4220

Frederiksen, KS, Verdelho, A, Madureira, S, Bäzner, H, O'Brien, JT, Fazekas, F, Scheltens, P, Schmidt, R, Wallin, A, Wahlund, L-O, Erkinjunttii, T, Poggesi, A, Pantoni, L, Inzitari, D, Waldemar, G & LADIS Study 2015, 'Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study', International Journal of Geriatric Psychiatry, vol. 30, no. 7, pp. 744-50. https://doi.org/10.1002/gps.4220

@article{6d96cca462b7488fa8f45fcf68249bf1,

title = "Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study",

abstract = "OBJECTIVES: Physical activity reduces the risk of cognitive decline but may affect cognitive domains differently. We examined whether physical activity modifies processing speed, executive function and memory in a population of non-dementia elderly subjects with age-related white matter changes (ARWMC).METHODS: Data from the Leukoaraiosis And DISability (LADIS) study, a multicenter, European prospective cohort study aimed at examining the role of ARWMC in transition to disability, was used. Subjects in the LADIS study were clinically assessed yearly for 3 years including MRI at baseline and 3-year follow-up. Physical activity was assessed at baseline, and cognitive compound scores at baseline and 3-year assessment were used.RESULTS: Two-hundred-eighty-two subjects (age, y (mean (SD)): 73.1 (± 5.1); gender (f/m): 164/118); MMSE (mean (SD)): 28.3 (± 1.7)) who had not progressed to MCI or dementia, were included. Multiple variable linear regression analysis with baseline MMSE, education, gender, age, stroke, diabetes and ARWMC rating as covariates revealed that physical activity was associated with better scores at baseline and 3-year follow-up for executive function (baseline: β: 0.39, 95% CI: 0.13-0.90, p = 0.008; follow-up: β: 0.24, 95% CI: 0.10-0.38, p = 0.001) and processing speed (baseline: β: 0.48, 95% CI: 0.14-0.89, p = 0.005; follow-up: β: 0.15, 95% CI: 0.02-0.29, p = 0.02) but not memory. When including baseline cognitive score as a covariate in the analysis of 3-year follow-up scores, executive function remained significant (β: 0.11, 95% CI: 0-0.22, p = 0.04).CONCLUSION: Our findings confirm previous findings of a positive effect of physical activity on cognitive functions in elderly subjects, and further extends these by showing that the association is also present in patients with ARWMC.",

keywords = "Activities of Daily Living, Aged, Aged, 80 and over, Brain, Cognition, Dementia, Executive Function, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Mild Cognitive Impairment, Motor Activity, Neuropsychological Tests, Prospective Studies, Regression Analysis, White Matter",

author = "Frederiksen, {Kristian Steen} and Ana Verdelho and Sofia Madureira and Hansj{\"o}rg B{\"a}zner and O'Brien, {John T} and Franz Fazekas and Philip Scheltens and Reinhold Schmidt and Anders Wallin and Lars-Olof Wahlund and Timo Erkinjunttii and Anna Poggesi and Leonardo Pantoni and Domenico Inzitari and Gunhild Waldemar and {LADIS Study}",

note = "Copyright {\textcopyright} 2014 John Wiley & Sons, Ltd.",

year = "2015",

month = jul,

day = "1",

doi = "10.1002/gps.4220",

language = "English",

volume = "30",

pages = "744--50",

journal = "International Journal of Geriatric Psychiatry",

issn = "0885-6230",

publisher = "JohnWiley & Sons Ltd",

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TY - JOUR

T1 - Physical activity in the elderly is associated with improved executive function and processing speed

T2 - the LADIS Study

AU - Frederiksen, Kristian Steen

AU - Verdelho, Ana

AU - Madureira, Sofia

AU - Bäzner, Hansjörg

AU - O'Brien, John T

AU - Fazekas, Franz

AU - Scheltens, Philip

AU - Schmidt, Reinhold

AU - Wallin, Anders

AU - Wahlund, Lars-Olof

AU - Erkinjunttii, Timo

AU - Poggesi, Anna

AU - Pantoni, Leonardo

AU - Inzitari, Domenico

AU - Waldemar, Gunhild

AU - LADIS Study

PY - 2015/7/1

Y1 - 2015/7/1

N2 - OBJECTIVES: Physical activity reduces the risk of cognitive decline but may affect cognitive domains differently. We examined whether physical activity modifies processing speed, executive function and memory in a population of non-dementia elderly subjects with age-related white matter changes (ARWMC).METHODS: Data from the Leukoaraiosis And DISability (LADIS) study, a multicenter, European prospective cohort study aimed at examining the role of ARWMC in transition to disability, was used. Subjects in the LADIS study were clinically assessed yearly for 3 years including MRI at baseline and 3-year follow-up. Physical activity was assessed at baseline, and cognitive compound scores at baseline and 3-year assessment were used.RESULTS: Two-hundred-eighty-two subjects (age, y (mean (SD)): 73.1 (± 5.1); gender (f/m): 164/118); MMSE (mean (SD)): 28.3 (± 1.7)) who had not progressed to MCI or dementia, were included. Multiple variable linear regression analysis with baseline MMSE, education, gender, age, stroke, diabetes and ARWMC rating as covariates revealed that physical activity was associated with better scores at baseline and 3-year follow-up for executive function (baseline: β: 0.39, 95% CI: 0.13-0.90, p = 0.008; follow-up: β: 0.24, 95% CI: 0.10-0.38, p = 0.001) and processing speed (baseline: β: 0.48, 95% CI: 0.14-0.89, p = 0.005; follow-up: β: 0.15, 95% CI: 0.02-0.29, p = 0.02) but not memory. When including baseline cognitive score as a covariate in the analysis of 3-year follow-up scores, executive function remained significant (β: 0.11, 95% CI: 0-0.22, p = 0.04).CONCLUSION: Our findings confirm previous findings of a positive effect of physical activity on cognitive functions in elderly subjects, and further extends these by showing that the association is also present in patients with ARWMC.

AB - OBJECTIVES: Physical activity reduces the risk of cognitive decline but may affect cognitive domains differently. We examined whether physical activity modifies processing speed, executive function and memory in a population of non-dementia elderly subjects with age-related white matter changes (ARWMC).METHODS: Data from the Leukoaraiosis And DISability (LADIS) study, a multicenter, European prospective cohort study aimed at examining the role of ARWMC in transition to disability, was used. Subjects in the LADIS study were clinically assessed yearly for 3 years including MRI at baseline and 3-year follow-up. Physical activity was assessed at baseline, and cognitive compound scores at baseline and 3-year assessment were used.RESULTS: Two-hundred-eighty-two subjects (age, y (mean (SD)): 73.1 (± 5.1); gender (f/m): 164/118); MMSE (mean (SD)): 28.3 (± 1.7)) who had not progressed to MCI or dementia, were included. Multiple variable linear regression analysis with baseline MMSE, education, gender, age, stroke, diabetes and ARWMC rating as covariates revealed that physical activity was associated with better scores at baseline and 3-year follow-up for executive function (baseline: β: 0.39, 95% CI: 0.13-0.90, p = 0.008; follow-up: β: 0.24, 95% CI: 0.10-0.38, p = 0.001) and processing speed (baseline: β: 0.48, 95% CI: 0.14-0.89, p = 0.005; follow-up: β: 0.15, 95% CI: 0.02-0.29, p = 0.02) but not memory. When including baseline cognitive score as a covariate in the analysis of 3-year follow-up scores, executive function remained significant (β: 0.11, 95% CI: 0-0.22, p = 0.04).CONCLUSION: Our findings confirm previous findings of a positive effect of physical activity on cognitive functions in elderly subjects, and further extends these by showing that the association is also present in patients with ARWMC.

KW - Activities of Daily Living

KW - Aged

KW - Aged, 80 and over

KW - Brain

KW - Cognition

KW - Dementia

KW - Executive Function

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory, Short-Term

KW - Middle Aged

KW - Mild Cognitive Impairment

KW - Motor Activity

KW - Neuropsychological Tests

KW - Prospective Studies

KW - Regression Analysis

KW - White Matter

U2 - 10.1002/gps.4220

DO - 10.1002/gps.4220

M3 - Journal article

C2 - 25363336

SN - 0885-6230

VL - 30

SP - 744

EP - 750

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

IS - 7

ER -

Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study

Abstract

Keywords

UN SDGs

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