Physical activity and capacity at initiation of antiretroviral treatment in HIV patients in Ethiopia

Mette Frahm Olsen; Pernille Kæstel; M Tesfaye; A Abdissa; D Yilma; T Girma; Christian Mølgaard; D Faurholt-Jepsen; Dirk Lund Christensen; S Brage; A B Andersen; Henrik Friis

doi:10.1017/s0950268814001502

Physical activity and capacity at initiation of antiretroviral treatment in HIV patients in Ethiopia

Mette Frahm Olsen, Pernille Kæstel, M Tesfaye, A Abdissa, D Yilma, T Girma, Christian Mølgaard, D Faurholt-Jepsen, Dirk Lund Christensen, S Brage, A B Andersen, Henrik Friis

Lifecourse Nutrition & Health

17 Citations (Scopus)

Abstract

We described levels of habitual physical activity and physical capacity in HIV patients initiating antiretroviral treatment in Ethiopia and assessed the role of HIV and nutritional indicators on these outcomes. Physical activity energy expenditure (PAEE) and activity levels were measured with combined heart rate and movement sensors. Physical capacity was assessed by grip strength, sleeping heart rate and heart rate economy. Grip strength data was also available from a sex- and age-matched HIV-negative reference group. Median PAEE was 27·9 (interquartile range 17·4-39·8) kJ/kg per day and mean±s.d. grip strength was 23·6 ± 6·7 kg. Advanced HIV disease predicted reduced levels of both physical activity and capacity; e.g. each unit viral load [log(1+copies/ml)] was associated with -15% PAEE (P < 0·001) and -1·0 kg grip strength (P < 0·001). Grip strength was 4·2 kg lower in patients compared to HIV-negative individuals (P < 0·001). Low body mass index (BMI) predicted poor physical activity and capacity independently of HIV status, e.g. BMI <16 was associated with -42% PAEE (P < 0·001) and -6·8 kg grip strength (P < 0·001) compared to BMI

Original language	English
Journal	Epidemiology and Infection
Volume	143
Issue number	5
Pages (from-to)	1048-1058
Number of pages	11
ISSN	0950-2688
DOIs	https://doi.org/10.1017/s0950268814001502
Publication status	Published - 11 Apr 2015

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title = "Physical activity and capacity at initiation of antiretroviral treatment in HIV patients in Ethiopia",

abstract = "We described levels of habitual physical activity and physical capacity in HIV patients initiating antiretroviral treatment in Ethiopia and assessed the role of HIV and nutritional indicators on these outcomes. Physical activity energy expenditure (PAEE) and activity levels were measured with combined heart rate and movement sensors. Physical capacity was assessed by grip strength, sleeping heart rate and heart rate economy. Grip strength data was also available from a sex- and age-matched HIV-negative reference group. Median PAEE was 27·9 (interquartile range 17·4-39·8) kJ/kg per day and mean±s.d. grip strength was 23·6 ± 6·7 kg. Advanced HIV disease predicted reduced levels of both physical activity and capacity; e.g. each unit viral load [log(1+copies/ml)] was associated with -15% PAEE (P < 0·001) and -1·0 kg grip strength (P < 0·001). Grip strength was 4·2 kg lower in patients compared to HIV-negative individuals (P < 0·001). Low body mass index (BMI) predicted poor physical activity and capacity independently of HIV status, e.g. BMI <16 was associated with -42% PAEE (P < 0·001) and -6·8 kg grip strength (P < 0·001) compared to BMI",

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T1 - Physical activity and capacity at initiation of antiretroviral treatment in HIV patients in Ethiopia

AU - Olsen, Mette Frahm

AU - Kæstel, Pernille

AU - Tesfaye, M

AU - Abdissa, A

AU - Yilma, D

AU - Girma, T

AU - Mølgaard, Christian

AU - Faurholt-Jepsen, D

AU - Christensen, Dirk Lund

AU - Brage, S

AU - Andersen, A B

AU - Friis, Henrik

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N2 - We described levels of habitual physical activity and physical capacity in HIV patients initiating antiretroviral treatment in Ethiopia and assessed the role of HIV and nutritional indicators on these outcomes. Physical activity energy expenditure (PAEE) and activity levels were measured with combined heart rate and movement sensors. Physical capacity was assessed by grip strength, sleeping heart rate and heart rate economy. Grip strength data was also available from a sex- and age-matched HIV-negative reference group. Median PAEE was 27·9 (interquartile range 17·4-39·8) kJ/kg per day and mean±s.d. grip strength was 23·6 ± 6·7 kg. Advanced HIV disease predicted reduced levels of both physical activity and capacity; e.g. each unit viral load [log(1+copies/ml)] was associated with -15% PAEE (P < 0·001) and -1·0 kg grip strength (P < 0·001). Grip strength was 4·2 kg lower in patients compared to HIV-negative individuals (P < 0·001). Low body mass index (BMI) predicted poor physical activity and capacity independently of HIV status, e.g. BMI <16 was associated with -42% PAEE (P < 0·001) and -6·8 kg grip strength (P < 0·001) compared to BMI

AB - We described levels of habitual physical activity and physical capacity in HIV patients initiating antiretroviral treatment in Ethiopia and assessed the role of HIV and nutritional indicators on these outcomes. Physical activity energy expenditure (PAEE) and activity levels were measured with combined heart rate and movement sensors. Physical capacity was assessed by grip strength, sleeping heart rate and heart rate economy. Grip strength data was also available from a sex- and age-matched HIV-negative reference group. Median PAEE was 27·9 (interquartile range 17·4-39·8) kJ/kg per day and mean±s.d. grip strength was 23·6 ± 6·7 kg. Advanced HIV disease predicted reduced levels of both physical activity and capacity; e.g. each unit viral load [log(1+copies/ml)] was associated with -15% PAEE (P < 0·001) and -1·0 kg grip strength (P < 0·001). Grip strength was 4·2 kg lower in patients compared to HIV-negative individuals (P < 0·001). Low body mass index (BMI) predicted poor physical activity and capacity independently of HIV status, e.g. BMI <16 was associated with -42% PAEE (P < 0·001) and -6·8 kg grip strength (P < 0·001) compared to BMI

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DO - 10.1017/s0950268814001502

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SN - 0950-2688

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EP - 1058

JO - Epidemiology and Infection

JF - Epidemiology and Infection

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Physical activity and capacity at initiation of antiretroviral treatment in HIV patients in Ethiopia

Abstract

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