Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002

Iben Stokholm; Tero Härkönen; Karin C. Harding; Ursula Siebert; Kristina Lehnert; Rune Dietz; Jonas Teilmann; Anders Galatius; Linnea Worsøe Havmøller; Emma L. Carroll; Ailsa Hall; Morten Tange Olsen

doi:10.3354/dao03328

Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002

Iben Stokholm, Tero Härkönen, Karin C. Harding, Ursula Siebert, Kristina Lehnert, Rune Dietz, Jonas Teilmann, Anders Galatius, Linnea Worsøe Havmøller, Emma L. Carroll, Ailsa Hall, Morten Tange Olsen

2 Citations (Scopus)

Abstract

The 1988 and 2002 phocine distemper virus (PDV) outbreaks in European harbour seals Phoca vitulina are among the largest mass mortality events recorded in marine mammals. Despite its large impact on harbour seal population numbers, and 3 decades of studies, many questions regarding the spread and temporal origin of PDV remain unanswered. Here, we sequenced and analysed 7123 bp of the PDV genome, including the coding and non-coding regions of the entire P, M, F and H genes in tissues from 44 harbour seals to shed new light on the origin and spread of PDV in 1988 and 2002. The phylogenetic analyses trace the origin of the PDV strain causing the 1988 outbreak to between June 1987 and April 1988, while the origin of the strain causing the 2002 outbreak can be traced back to between July 2001 and April 2002. The analyses further point to several independent introductions of PDV in 1988, possibly linked to a southward mass immigration of harp seals in the winter and spring of 1987−1988. The vector for the 2002 outbreak is unknown, but the epidemiological analyses suggest the subsequent spread of PDV from the epicentre in the Kattegat, Denmark, to haul-out sites in the North Sea through several independent introductions.

Original language	English
Journal	Diseases of Aquatic Organisms
Volume	133
Issue number	1
Pages (from-to)	47-56
Number of pages	10
ISSN	0177-5103
DOIs	https://doi.org/10.3354/dao03328
Publication status	Published - 2019

Keywords

Epidemic
Morbillivirus
Viral phylogeny
Virus evolution
Wildlife pathogen

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3354/dao03328

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Stokholm, I., Härkönen, T., Harding, K. C., Siebert, U., Lehnert, K., Dietz, R., Teilmann, J., Galatius, A., Havmøller, L. W., Carroll, E. L., Hall, A., & Olsen, M. T. (2019). Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002. Diseases of Aquatic Organisms, 133(1), 47-56. https://doi.org/10.3354/dao03328

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title = "Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002",

abstract = "The 1988 and 2002 phocine distemper virus (PDV) outbreaks in European harbour seals Phoca vitulina are among the largest mass mortality events recorded in marine mammals. Despite its large impact on harbour seal population numbers, and 3 decades of studies, many questions regarding the spread and temporal origin of PDV remain unanswered. Here, we sequenced and analysed 7123 bp of the PDV genome, including the coding and non-coding regions of the entire P, M, F and H genes in tissues from 44 harbour seals to shed new light on the origin and spread of PDV in 1988 and 2002. The phylogenetic analyses trace the origin of the PDV strain causing the 1988 outbreak to between June 1987 and April 1988, while the origin of the strain causing the 2002 outbreak can be traced back to between July 2001 and April 2002. The analyses further point to several independent introductions of PDV in 1988, possibly linked to a southward mass immigration of harp seals in the winter and spring of 1987−1988. The vector for the 2002 outbreak is unknown, but the epidemiological analyses suggest the subsequent spread of PDV from the epicentre in the Kattegat, Denmark, to haul-out sites in the North Sea through several independent introductions.",

keywords = "Epidemic, Morbillivirus, Viral phylogeny, Virus evolution, Wildlife pathogen",

author = "Iben Stokholm and Tero H{\"a}rk{\"o}nen and Harding, {Karin C.} and Ursula Siebert and Kristina Lehnert and Rune Dietz and Jonas Teilmann and Anders Galatius and Havm{\o}ller, {Linnea Wors{\o}e} and Carroll, {Emma L.} and Ailsa Hall and Olsen, {Morten Tange}",

year = "2019",

doi = "10.3354/dao03328",

language = "English",

volume = "133",

pages = "47--56",

journal = "Diseases of Aquatic Organisms",

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T1 - Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002

AU - Stokholm, Iben

AU - Härkönen, Tero

AU - Harding, Karin C.

AU - Siebert, Ursula

AU - Lehnert, Kristina

AU - Dietz, Rune

AU - Teilmann, Jonas

AU - Galatius, Anders

AU - Havmøller, Linnea Worsøe

AU - Carroll, Emma L.

AU - Hall, Ailsa

AU - Olsen, Morten Tange

PY - 2019

Y1 - 2019

N2 - The 1988 and 2002 phocine distemper virus (PDV) outbreaks in European harbour seals Phoca vitulina are among the largest mass mortality events recorded in marine mammals. Despite its large impact on harbour seal population numbers, and 3 decades of studies, many questions regarding the spread and temporal origin of PDV remain unanswered. Here, we sequenced and analysed 7123 bp of the PDV genome, including the coding and non-coding regions of the entire P, M, F and H genes in tissues from 44 harbour seals to shed new light on the origin and spread of PDV in 1988 and 2002. The phylogenetic analyses trace the origin of the PDV strain causing the 1988 outbreak to between June 1987 and April 1988, while the origin of the strain causing the 2002 outbreak can be traced back to between July 2001 and April 2002. The analyses further point to several independent introductions of PDV in 1988, possibly linked to a southward mass immigration of harp seals in the winter and spring of 1987−1988. The vector for the 2002 outbreak is unknown, but the epidemiological analyses suggest the subsequent spread of PDV from the epicentre in the Kattegat, Denmark, to haul-out sites in the North Sea through several independent introductions.

AB - The 1988 and 2002 phocine distemper virus (PDV) outbreaks in European harbour seals Phoca vitulina are among the largest mass mortality events recorded in marine mammals. Despite its large impact on harbour seal population numbers, and 3 decades of studies, many questions regarding the spread and temporal origin of PDV remain unanswered. Here, we sequenced and analysed 7123 bp of the PDV genome, including the coding and non-coding regions of the entire P, M, F and H genes in tissues from 44 harbour seals to shed new light on the origin and spread of PDV in 1988 and 2002. The phylogenetic analyses trace the origin of the PDV strain causing the 1988 outbreak to between June 1987 and April 1988, while the origin of the strain causing the 2002 outbreak can be traced back to between July 2001 and April 2002. The analyses further point to several independent introductions of PDV in 1988, possibly linked to a southward mass immigration of harp seals in the winter and spring of 1987−1988. The vector for the 2002 outbreak is unknown, but the epidemiological analyses suggest the subsequent spread of PDV from the epicentre in the Kattegat, Denmark, to haul-out sites in the North Sea through several independent introductions.

KW - Epidemic

KW - Morbillivirus

KW - Viral phylogeny

KW - Virus evolution

KW - Wildlife pathogen

UR - http://www.mendeley.com/research/phylogenomic-insights-origin-spread-phocine-distemper-virus-european-harbour-seals-1988-2002

U2 - 10.3354/dao03328

DO - 10.3354/dao03328

M3 - Journal article

C2 - 31089002

SN - 0177-5103

VL - 133

SP - 47

EP - 56

JO - Diseases of Aquatic Organisms

JF - Diseases of Aquatic Organisms

IS - 1

ER -

Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002

Abstract

Keywords

UN SDGs

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