Phospholipase A2 - An enzyme that is sensitive to the physics of its substrate

P. Høyrup; K. Jørgensen; O. G. Mouritsen

doi:10.1209/epl/i2002-00483-y

Phospholipase A₂ - An enzyme that is sensitive to the physics of its substrate

P. Høyrup^*, K. Jørgensen, O. G. Mouritsen

^*Corresponding author for this work

25 Citations (Scopus)

Abstract

A simple statistical mechanical model of lipid bilayers is proposed to account for the non-equilibrium action of the enzyme phospholipase A₂. The enzyme hydrolyses lipid-bilayer substrates and produces product molecules that lead to local variations in the bilayer interracial pressure. Computer simulation of the model shows, in quantitative agreement with experimental data, that the enzyme activity is modulated by nano-scale lipid-domain formation in the lipid bilayer leading to a characteristic lag-burst behavior.

Original language	English
Journal	Europhysics Letters
Volume	57
Issue number	3
Pages (from-to)	464-470
Number of pages	7
ISSN	0295-5075
DOIs	https://doi.org/10.1209/epl/i2002-00483-y
Publication status	Published - 19 Aug 2002

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abstract = "A simple statistical mechanical model of lipid bilayers is proposed to account for the non-equilibrium action of the enzyme phospholipase A2. The enzyme hydrolyses lipid-bilayer substrates and produces product molecules that lead to local variations in the bilayer interracial pressure. Computer simulation of the model shows, in quantitative agreement with experimental data, that the enzyme activity is modulated by nano-scale lipid-domain formation in the lipid bilayer leading to a characteristic lag-burst behavior.",

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AB - A simple statistical mechanical model of lipid bilayers is proposed to account for the non-equilibrium action of the enzyme phospholipase A2. The enzyme hydrolyses lipid-bilayer substrates and produces product molecules that lead to local variations in the bilayer interracial pressure. Computer simulation of the model shows, in quantitative agreement with experimental data, that the enzyme activity is modulated by nano-scale lipid-domain formation in the lipid bilayer leading to a characteristic lag-burst behavior.

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Phospholipase A₂ - An enzyme that is sensitive to the physics of its substrate

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