Pharmacotherapy and hospital admissions before out-of-hospital cardiac arrest: a nationwide study

Peter Weeke; Fredrik Folke; Gunnar Hilmar Gislason; Freddy Lippert; Jonas Bjerring Olesen; Charlotte Andersson; Emil L Fosbøl; Mette G Charlot; Jørgen K. Kanters; Henrik E Poulsen; Søren Loumann Nielsen; Lars Køber; Christian Torp-Pedersen

doi:10.1016/j.resuscitation.2010.06.025

Pharmacotherapy and hospital admissions before out-of-hospital cardiac arrest: a nationwide study

Peter Weeke, Fredrik Folke, Gunnar Hilmar Gislason, Freddy Lippert, Jonas Bjerring Olesen, Charlotte Andersson, Emil L Fosbøl, Mette G Charlot, Jørgen K. Kanters, Henrik E Poulsen, Søren Loumann Nielsen, Lars Køber, Christian Torp-Pedersen

9 Citations (Scopus)

Abstract

Background: For out-of-hospital cardiac arrest (OHCA) to be predicted and prevented, it is imperative the healthcare system has access to those vulnerable before the event occurs. We aimed to determine the extent of contact to the healthcare system before OHCA. Methods: All patients in Denmark with a registered OHCA June 1, 2001-December 31, 2005 were matched on age and sex with 10 random controls from the entire Danish population. We estimated the association with OHCA by conditional logistic regression analyses, and we determined the proportion of patients in contact with the healthcare system before OHCA from hospital admissions or claimed prescriptions. Results: We identified 12,089 patients with an OHCA. Of these, 62% (7548) and 85% (10,312) were in contact with the healthcare system up to 30 days and 1 year before OHCA, respectively. Association with OHCA up to 30 days before the event pertained to myocardial infarction (odds ratio (OR). = 6.4, 95% confidence interval (CI): 4.7-8.6)); heart failure (OR. = 5.1, CI: 4.1-6.3); ischemic heart disease (OR. = 1.9, CI: 1.6-2.4); and cardiac dysrhythmia (OR. = 1.8, CI: 1.4-2.2). Concomitant pharmacotherapy up to 30 days before OHCA with the strongest association was: corticosteroids (systemic) (OR. = 2.7, CI: 2.5-3.0), bronchial dilators (OR. = 2.5, CI: 2.3-2.7), anti-psychotic medication (OR. = 2.1, CI: 1.9-2.3), and digoxin (OR. = 2.1, CI: 2.0-2.3). Similar results were found for associations up to 1 year before OHCA. Conclusion: Contrary to general belief, the majority of OHCA patients are in contact with the healthcare system shortly before OHCA.

Original language	English
Journal	Resuscitation
Volume	81
Issue number	12
Pages (from-to)	1657-1663
Number of pages	7
ISSN	0300-9572
DOIs	https://doi.org/10.1016/j.resuscitation.2010.06.025
Publication status	Published - 1 Dec 2010

Keywords

Adrenal Cortex Hormones
Aged
Antipsychotic Agents
Arrhythmias, Cardiac
Bronchodilator Agents
Denmark
Digoxin
Female
Health Behavior
Heart Failure
Humans
Male
Middle Aged
Myocardial Infarction
Myocardial Ischemia
Out-of-Hospital Cardiac Arrest
Patient Admission
Regression Analysis

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Weeke, P., Folke, F., Gislason, G. H., Lippert, F., Olesen, J. B., Andersson, C., Fosbøl, E. L., Charlot, M. G., Kanters, J. K., Poulsen, H. E., Nielsen, S. L., Køber, L., & Torp-Pedersen, C. (2010). Pharmacotherapy and hospital admissions before out-of-hospital cardiac arrest: a nationwide study. Resuscitation, 81(12), 1657-1663. https://doi.org/10.1016/j.resuscitation.2010.06.025

Weeke, P, Folke, F , Gislason, GH , Lippert, F, Olesen, JB, Andersson, C, Fosbøl, EL, Charlot, MG, Kanters, JK , Poulsen, HE, Nielsen, SL, Køber, L & Torp-Pedersen, C 2010, 'Pharmacotherapy and hospital admissions before out-of-hospital cardiac arrest: a nationwide study', Resuscitation, vol. 81, no. 12, pp. 1657-1663. https://doi.org/10.1016/j.resuscitation.2010.06.025

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title = "Pharmacotherapy and hospital admissions before out-of-hospital cardiac arrest: a nationwide study",

abstract = "Background: For out-of-hospital cardiac arrest (OHCA) to be predicted and prevented, it is imperative the healthcare system has access to those vulnerable before the event occurs. We aimed to determine the extent of contact to the healthcare system before OHCA. Methods: All patients in Denmark with a registered OHCA June 1, 2001-December 31, 2005 were matched on age and sex with 10 random controls from the entire Danish population. We estimated the association with OHCA by conditional logistic regression analyses, and we determined the proportion of patients in contact with the healthcare system before OHCA from hospital admissions or claimed prescriptions. Results: We identified 12,089 patients with an OHCA. Of these, 62% (7548) and 85% (10,312) were in contact with the healthcare system up to 30 days and 1 year before OHCA, respectively. Association with OHCA up to 30 days before the event pertained to myocardial infarction (odds ratio (OR). = 6.4, 95% confidence interval (CI): 4.7-8.6)); heart failure (OR. = 5.1, CI: 4.1-6.3); ischemic heart disease (OR. = 1.9, CI: 1.6-2.4); and cardiac dysrhythmia (OR. = 1.8, CI: 1.4-2.2). Concomitant pharmacotherapy up to 30 days before OHCA with the strongest association was: corticosteroids (systemic) (OR. = 2.7, CI: 2.5-3.0), bronchial dilators (OR. = 2.5, CI: 2.3-2.7), anti-psychotic medication (OR. = 2.1, CI: 1.9-2.3), and digoxin (OR. = 2.1, CI: 2.0-2.3). Similar results were found for associations up to 1 year before OHCA. Conclusion: Contrary to general belief, the majority of OHCA patients are in contact with the healthcare system shortly before OHCA.",

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author = "Peter Weeke and Fredrik Folke and Gislason, {Gunnar Hilmar} and Freddy Lippert and Olesen, {Jonas Bjerring} and Charlotte Andersson and Fosb{\o}l, {Emil L} and Charlot, {Mette G} and Kanters, {J{\o}rgen K.} and Poulsen, {Henrik E} and Nielsen, {S{\o}ren Loumann} and Lars K{\o}ber and Christian Torp-Pedersen",

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doi = "10.1016/j.resuscitation.2010.06.025",

language = "English",

volume = "81",

pages = "1657--1663",

journal = "Resuscitation",

issn = "0300-9572",

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number = "12",

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TY - JOUR

T1 - Pharmacotherapy and hospital admissions before out-of-hospital cardiac arrest

T2 - a nationwide study

AU - Weeke, Peter

AU - Folke, Fredrik

AU - Gislason, Gunnar Hilmar

AU - Lippert, Freddy

AU - Olesen, Jonas Bjerring

AU - Andersson, Charlotte

AU - Fosbøl, Emil L

AU - Charlot, Mette G

AU - Kanters, Jørgen K.

AU - Poulsen, Henrik E

AU - Nielsen, Søren Loumann

AU - Køber, Lars

AU - Torp-Pedersen, Christian

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Background: For out-of-hospital cardiac arrest (OHCA) to be predicted and prevented, it is imperative the healthcare system has access to those vulnerable before the event occurs. We aimed to determine the extent of contact to the healthcare system before OHCA. Methods: All patients in Denmark with a registered OHCA June 1, 2001-December 31, 2005 were matched on age and sex with 10 random controls from the entire Danish population. We estimated the association with OHCA by conditional logistic regression analyses, and we determined the proportion of patients in contact with the healthcare system before OHCA from hospital admissions or claimed prescriptions. Results: We identified 12,089 patients with an OHCA. Of these, 62% (7548) and 85% (10,312) were in contact with the healthcare system up to 30 days and 1 year before OHCA, respectively. Association with OHCA up to 30 days before the event pertained to myocardial infarction (odds ratio (OR). = 6.4, 95% confidence interval (CI): 4.7-8.6)); heart failure (OR. = 5.1, CI: 4.1-6.3); ischemic heart disease (OR. = 1.9, CI: 1.6-2.4); and cardiac dysrhythmia (OR. = 1.8, CI: 1.4-2.2). Concomitant pharmacotherapy up to 30 days before OHCA with the strongest association was: corticosteroids (systemic) (OR. = 2.7, CI: 2.5-3.0), bronchial dilators (OR. = 2.5, CI: 2.3-2.7), anti-psychotic medication (OR. = 2.1, CI: 1.9-2.3), and digoxin (OR. = 2.1, CI: 2.0-2.3). Similar results were found for associations up to 1 year before OHCA. Conclusion: Contrary to general belief, the majority of OHCA patients are in contact with the healthcare system shortly before OHCA.

AB - Background: For out-of-hospital cardiac arrest (OHCA) to be predicted and prevented, it is imperative the healthcare system has access to those vulnerable before the event occurs. We aimed to determine the extent of contact to the healthcare system before OHCA. Methods: All patients in Denmark with a registered OHCA June 1, 2001-December 31, 2005 were matched on age and sex with 10 random controls from the entire Danish population. We estimated the association with OHCA by conditional logistic regression analyses, and we determined the proportion of patients in contact with the healthcare system before OHCA from hospital admissions or claimed prescriptions. Results: We identified 12,089 patients with an OHCA. Of these, 62% (7548) and 85% (10,312) were in contact with the healthcare system up to 30 days and 1 year before OHCA, respectively. Association with OHCA up to 30 days before the event pertained to myocardial infarction (odds ratio (OR). = 6.4, 95% confidence interval (CI): 4.7-8.6)); heart failure (OR. = 5.1, CI: 4.1-6.3); ischemic heart disease (OR. = 1.9, CI: 1.6-2.4); and cardiac dysrhythmia (OR. = 1.8, CI: 1.4-2.2). Concomitant pharmacotherapy up to 30 days before OHCA with the strongest association was: corticosteroids (systemic) (OR. = 2.7, CI: 2.5-3.0), bronchial dilators (OR. = 2.5, CI: 2.3-2.7), anti-psychotic medication (OR. = 2.1, CI: 1.9-2.3), and digoxin (OR. = 2.1, CI: 2.0-2.3). Similar results were found for associations up to 1 year before OHCA. Conclusion: Contrary to general belief, the majority of OHCA patients are in contact with the healthcare system shortly before OHCA.

KW - Adrenal Cortex Hormones

KW - Aged

KW - Antipsychotic Agents

KW - Arrhythmias, Cardiac

KW - Bronchodilator Agents

KW - Denmark

KW - Digoxin

KW - Female

KW - Health Behavior

KW - Heart Failure

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Myocardial Ischemia

KW - Out-of-Hospital Cardiac Arrest

KW - Patient Admission

KW - Regression Analysis

U2 - 10.1016/j.resuscitation.2010.06.025

DO - 10.1016/j.resuscitation.2010.06.025

M3 - Journal article

C2 - 20727660

SN - 0300-9572

VL - 81

SP - 1657

EP - 1663

JO - Resuscitation

JF - Resuscitation

IS - 12

ER -

Pharmacotherapy and hospital admissions before out-of-hospital cardiac arrest: a nationwide study

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Keywords

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