Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations

TY - JOUR

T1 - Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations

AU - Christiansen, B

AU - Hansen, K B

AU - Wellendorph, P

AU - Bräuner-Osborne, Hans

PY - 2007

Y1 - 2007

N2 - GPRC6A is a novel member of family C of G protein-coupled receptors with so far unknown function. We have recently described both human and mouse GPRC6A as receptors for L-alpha-amino acids. To date, functional characterization of wild-type GPRC6A has been impaired by the lack of activity in quantitative functional assays. The aim of this study was thus to develop such an assay and extend the pharmacological characterization of GPRC6A.

AB - GPRC6A is a novel member of family C of G protein-coupled receptors with so far unknown function. We have recently described both human and mouse GPRC6A as receptors for L-alpha-amino acids. To date, functional characterization of wild-type GPRC6A has been impaired by the lack of activity in quantitative functional assays. The aim of this study was thus to develop such an assay and extend the pharmacological characterization of GPRC6A.

KW - Animals

KW - Arginine

KW - Calcium

KW - Cations, Divalent

KW - Female

KW - GTP-Binding Protein alpha Subunits

KW - Humans

KW - Inositol Phosphates

KW - Kinetics

KW - Lysine

KW - Magnesium

KW - Mice

KW - Oocytes

KW - Ornithine

KW - Rats

KW - Receptors, Amino Acid

KW - Receptors, G-Protein-Coupled

KW - Recombinant Proteins

KW - Transfection

KW - Xenopus laevis

U2 - 10.1038/sj.bjp.0707121

DO - 10.1038/sj.bjp.0707121

M3 - Journal article

C2 - 17245368

SN - 0007-1188

VL - 150

SP - 798

EP - 807

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 6

ER -