Pharmacologic Strategies for Exercise-Induced Bronchospasm with a Focus on Athletes

TY - JOUR

T1 - Pharmacologic Strategies for Exercise-Induced Bronchospasm with a Focus on Athletes

AU - Backer, Vibeke

AU - Mastronarde, John

PY - 2018

Y1 - 2018

N2 - Exercise-induced bronchoconstriction (EIB) is the transient narrowing of the airways during and after exercise that occurs in response to increased ventilation in susceptible individuals. It occurs across the age spectrum in patients with underlying asthma and can occur in athletes without baseline asthma. The inflammatory mechanisms underlying EIB in patients without asthma may be distinct from those underlying EIB in patients with asthma. This review summarizes mechanistic and clinical data that can guide the choice of chronic and acute pharmacologic therapies targeting control of EIB. Relevant regulations from the World Anti-Doping Agency are also discussed.

AB - Exercise-induced bronchoconstriction (EIB) is the transient narrowing of the airways during and after exercise that occurs in response to increased ventilation in susceptible individuals. It occurs across the age spectrum in patients with underlying asthma and can occur in athletes without baseline asthma. The inflammatory mechanisms underlying EIB in patients without asthma may be distinct from those underlying EIB in patients with asthma. This review summarizes mechanistic and clinical data that can guide the choice of chronic and acute pharmacologic therapies targeting control of EIB. Relevant regulations from the World Anti-Doping Agency are also discussed.

KW - Asthma

KW - Doping

KW - EIB

KW - Exercise

KW - Treatment

U2 - 10.1016/j.iac.2018.01.011

DO - 10.1016/j.iac.2018.01.011

M3 - Review

C2 - 29631732

AN - SCOPUS:85044939275

SN - 0889-8561

VL - 38

SP - 231

EP - 243

JO - Immunology and Allergy Clinics of North America

JF - Immunology and Allergy Clinics of North America

IS - 2

ER -