PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites

Gitte Andersen; Lise Wegner; Dorit Packert Jensen; Charlotte Glümer; Lise Tarnow; Thomas Drivsholm; Pernille Poulsen; Sara Kristine Hansen; Eva-Maria Damsgaard Nielsen; Jakob Ek; Peter Mouritzen; Allan Vaag; Hans-Henrik Parving; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen

doi:10.1161/01.HYP.0000158946.53289.24

PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites

Gitte Andersen, Lise Wegner, Dorit Packert Jensen, Charlotte Glümer, Lise Tarnow, Thomas Drivsholm, Pernille Poulsen, Sara Kristine Hansen, Eva-Maria Damsgaard Nielsen, Jakob Ek, Peter Mouritzen, Allan Vaag, Hans-Henrik Parving, Knut Borch-Johnsen, Torben Jørgensen, Torben Hansen, Oluf Pedersen

36 Citations (Scopus)

Abstract

PGC-1alpha is a coactivator of numerous transcription factors and is expressed in tissues with high energy demands and abundant in mitochondria. It is induced in the myocardium on fasting and physical exercise, and cardiac-specific overexpression stimulates mitochondrial biogenesis in mice. The common Gly482Ser polymorphism of PGC-1alpha has previously shown association with arterial hypertension among Austrian men. Thus, we aimed at investigating this relationship in the Danish white population. The Gly482Ser polymorphism was genotyped in a total of 2562 Danish white subjects using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) and a GenoView locked nucleic acid assay (LNA), and the relationships of this variant with blood pressure levels and arterial hypertension were analyzed. Furthermore, we performed a combined analysis of the data from the present study in combination with previously published results. The Ser/Ser genotype was significantly associated with a reduced risk of hypertension and with lower systolic, diastolic, and mean arterial blood pressure levels, predominantly among women. Finally, in a combined analysis using data obtained in both sexes, the Ser/Ser genotype group had an estimated odds ratio of 0.70 (95% confidence interval, 0.56 to 0.86) for hypertension compared with Gly/X carriers (P=0.001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women.

Original language	English
Journal	Hypertension
Volume	45
Issue number	4
Pages (from-to)	565-70
Number of pages	6
DOIs	https://doi.org/10.1161/01.HYP.0000158946.53289.24
Publication status	Published - 1 Apr 2005

Keywords

Adult
Aged
Blood Pressure
Denmark
European Continental Ancestry Group
Female
Genetic Predisposition to Disease
Genotype
Glycine
Heat-Shock Proteins
Humans
Hypertension
Male
Middle Aged
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Reverse Transcriptase Polymerase Chain Reaction
Risk
Serine
Sex Characteristics
Transcription Factors

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Andersen, G., Wegner, L., Jensen, D. P., Glümer, C., Tarnow, L., Drivsholm, T., Poulsen, P., Hansen, S. K., Nielsen, E-M. D., Ek, J., Mouritzen, P., Vaag, A., Parving, H-H., Borch-Johnsen, K., Jørgensen, T., Hansen, T., & Pedersen, O. (2005). PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites. Hypertension, 45(4), 565-70. https://doi.org/10.1161/01.HYP.0000158946.53289.24

Andersen, G, Wegner, L, Jensen, DP, Glümer, C, Tarnow, L, Drivsholm, T, Poulsen, P, Hansen, SK, Nielsen, E-MD, Ek, J, Mouritzen, P, Vaag, A, Parving, H-H, Borch-Johnsen, K, Jørgensen, T, Hansen, T & Pedersen, O 2005, 'PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites', Hypertension, vol. 45, no. 4, pp. 565-70. https://doi.org/10.1161/01.HYP.0000158946.53289.24

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title = "PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites",

abstract = "PGC-1alpha is a coactivator of numerous transcription factors and is expressed in tissues with high energy demands and abundant in mitochondria. It is induced in the myocardium on fasting and physical exercise, and cardiac-specific overexpression stimulates mitochondrial biogenesis in mice. The common Gly482Ser polymorphism of PGC-1alpha has previously shown association with arterial hypertension among Austrian men. Thus, we aimed at investigating this relationship in the Danish white population. The Gly482Ser polymorphism was genotyped in a total of 2562 Danish white subjects using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) and a GenoView locked nucleic acid assay (LNA), and the relationships of this variant with blood pressure levels and arterial hypertension were analyzed. Furthermore, we performed a combined analysis of the data from the present study in combination with previously published results. The Ser/Ser genotype was significantly associated with a reduced risk of hypertension and with lower systolic, diastolic, and mean arterial blood pressure levels, predominantly among women. Finally, in a combined analysis using data obtained in both sexes, the Ser/Ser genotype group had an estimated odds ratio of 0.70 (95% confidence interval, 0.56 to 0.86) for hypertension compared with Gly/X carriers (P=0.001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women.",

keywords = "Adult, Aged, Blood Pressure, Denmark, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genotype, Glycine, Heat-Shock Proteins, Humans, Hypertension, Male, Middle Aged, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Reverse Transcriptase Polymerase Chain Reaction, Risk, Serine, Sex Characteristics, Transcription Factors",

author = "Gitte Andersen and Lise Wegner and Jensen, {Dorit Packert} and Charlotte Gl{\"u}mer and Lise Tarnow and Thomas Drivsholm and Pernille Poulsen and Hansen, {Sara Kristine} and Nielsen, {Eva-Maria Damsgaard} and Jakob Ek and Peter Mouritzen and Allan Vaag and Hans-Henrik Parving and Knut Borch-Johnsen and Torben J{\o}rgensen and Torben Hansen and Oluf Pedersen",

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doi = "10.1161/01.HYP.0000158946.53289.24",

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T1 - PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites

AU - Andersen, Gitte

AU - Wegner, Lise

AU - Jensen, Dorit Packert

AU - Glümer, Charlotte

AU - Tarnow, Lise

AU - Drivsholm, Thomas

AU - Poulsen, Pernille

AU - Hansen, Sara Kristine

AU - Nielsen, Eva-Maria Damsgaard

AU - Ek, Jakob

AU - Mouritzen, Peter

AU - Vaag, Allan

AU - Parving, Hans-Henrik

AU - Borch-Johnsen, Knut

AU - Jørgensen, Torben

AU - Hansen, Torben

AU - Pedersen, Oluf

PY - 2005/4/1

Y1 - 2005/4/1

N2 - PGC-1alpha is a coactivator of numerous transcription factors and is expressed in tissues with high energy demands and abundant in mitochondria. It is induced in the myocardium on fasting and physical exercise, and cardiac-specific overexpression stimulates mitochondrial biogenesis in mice. The common Gly482Ser polymorphism of PGC-1alpha has previously shown association with arterial hypertension among Austrian men. Thus, we aimed at investigating this relationship in the Danish white population. The Gly482Ser polymorphism was genotyped in a total of 2562 Danish white subjects using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) and a GenoView locked nucleic acid assay (LNA), and the relationships of this variant with blood pressure levels and arterial hypertension were analyzed. Furthermore, we performed a combined analysis of the data from the present study in combination with previously published results. The Ser/Ser genotype was significantly associated with a reduced risk of hypertension and with lower systolic, diastolic, and mean arterial blood pressure levels, predominantly among women. Finally, in a combined analysis using data obtained in both sexes, the Ser/Ser genotype group had an estimated odds ratio of 0.70 (95% confidence interval, 0.56 to 0.86) for hypertension compared with Gly/X carriers (P=0.001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women.

AB - PGC-1alpha is a coactivator of numerous transcription factors and is expressed in tissues with high energy demands and abundant in mitochondria. It is induced in the myocardium on fasting and physical exercise, and cardiac-specific overexpression stimulates mitochondrial biogenesis in mice. The common Gly482Ser polymorphism of PGC-1alpha has previously shown association with arterial hypertension among Austrian men. Thus, we aimed at investigating this relationship in the Danish white population. The Gly482Ser polymorphism was genotyped in a total of 2562 Danish white subjects using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) and a GenoView locked nucleic acid assay (LNA), and the relationships of this variant with blood pressure levels and arterial hypertension were analyzed. Furthermore, we performed a combined analysis of the data from the present study in combination with previously published results. The Ser/Ser genotype was significantly associated with a reduced risk of hypertension and with lower systolic, diastolic, and mean arterial blood pressure levels, predominantly among women. Finally, in a combined analysis using data obtained in both sexes, the Ser/Ser genotype group had an estimated odds ratio of 0.70 (95% confidence interval, 0.56 to 0.86) for hypertension compared with Gly/X carriers (P=0.001). In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites. Further studies are needed to elucidate the differential role of this polymorphism in men and women.

KW - Adult

KW - Aged

KW - Blood Pressure

KW - Denmark

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Glycine

KW - Heat-Shock Proteins

KW - Humans

KW - Hypertension

KW - Male

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Polymorphism, Restriction Fragment Length

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Risk

KW - Serine

KW - Sex Characteristics

KW - Transcription Factors

U2 - 10.1161/01.HYP.0000158946.53289.24

DO - 10.1161/01.HYP.0000158946.53289.24

M3 - Journal article

C2 - 15738346

SN - 0194-911X

VL - 45

SP - 565

EP - 570

JO - Hypertension

JF - Hypertension

IS - 4

ER -

PGC-1alpha Gly482Ser polymorphism associates with hypertension among Danish whites

Abstract

Keywords

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