Pervasive introgression facilitated domestication and adaptation in the Bos species complex

Dong-Dong Wu; Xiang Dong Ding; Sheng Wang; Jan M. Wójcik; Yi Zhang; Małgorzata Tokarska; Yan Li; Ming Shan Wang; Omar Faruque; Rasmus Nielsen; Qin Zhang; Ya-Ping Zhang

doi:10.1038/s41559-018-0562-y

Pervasive introgression facilitated domestication and adaptation in the Bos species complex

Dong-Dong Wu^*, Xiang Dong Ding, Sheng Wang, Jan M. Wójcik, Yi Zhang, Małgorzata Tokarska, Yan Li, Ming Shan Wang, Omar Faruque, Rasmus Nielsen, Qin Zhang, Ya-Ping Zhang

^*Corresponding author for this work

59 Citations (Scopus)

Abstract

Species of the Bos genus, including taurine cattle, zebu, gayal, gaur, banteng, yak, wisent and bison, have been domesticated at least four times and have been an important source of meat, milk and power for many human cultures. We sequence the genomes of gayal, gaur, banteng, wisent and bison, and provide population genomic sequencing of an additional 98 individuals. We use these data to determine the phylogeny and evolutionary history of these species and show that the threatened gayal is an independent species or subspecies. We show that there has been pronounced introgression among different members of this genus, and that it in many cases has involved genes of considerable adaptive importance. For example, genes under domestication selection in cattle (for example, MITF) were introgressed from domestic cattle to yak. Also, genes in the response-to-hypoxia pathway (for example, EGLN1, EGLN2 and HIF3a) have been introgressed from yak to Tibetan cattle, probably facilitating their adaptation to high altitude. We also validate that there is an association between the introgressed EGLN1 allele and haemoglobin and red blood cell concentration. Our results illustrate the importance of introgression as a source of adaptive variation and during domestication, and suggest that the Bos genus evolves as a complex of genetically interconnected species with shared evolutionary trajectories.

Original language	English
Journal	Nature Ecology and Evolution
Volume	2
Issue number	7
Pages (from-to)	1139-1145
Number of pages	7
ISSN	2397-334X
DOIs	https://doi.org/10.1038/s41559-018-0562-y
Publication status	Published - 2018
Externally published	Yes

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title = "Pervasive introgression facilitated domestication and adaptation in the Bos species complex",

abstract = "Species of the Bos genus, including taurine cattle, zebu, gayal, gaur, banteng, yak, wisent and bison, have been domesticated at least four times and have been an important source of meat, milk and power for many human cultures. We sequence the genomes of gayal, gaur, banteng, wisent and bison, and provide population genomic sequencing of an additional 98 individuals. We use these data to determine the phylogeny and evolutionary history of these species and show that the threatened gayal is an independent species or subspecies. We show that there has been pronounced introgression among different members of this genus, and that it in many cases has involved genes of considerable adaptive importance. For example, genes under domestication selection in cattle (for example, MITF) were introgressed from domestic cattle to yak. Also, genes in the response-to-hypoxia pathway (for example, EGLN1, EGLN2 and HIF3a) have been introgressed from yak to Tibetan cattle, probably facilitating their adaptation to high altitude. We also validate that there is an association between the introgressed EGLN1 allele and haemoglobin and red blood cell concentration. Our results illustrate the importance of introgression as a source of adaptive variation and during domestication, and suggest that the Bos genus evolves as a complex of genetically interconnected species with shared evolutionary trajectories.",

author = "Dong-Dong Wu and Ding, {Xiang Dong} and Sheng Wang and W{\'o}jcik, {Jan M.} and Yi Zhang and Ma{\l}gorzata Tokarska and Yan Li and Wang, {Ming Shan} and Omar Faruque and Rasmus Nielsen and Qin Zhang and Ya-Ping Zhang",

year = "2018",

doi = "10.1038/s41559-018-0562-y",

language = "English",

volume = "2",

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journal = "Nature Ecology & Evolution",

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AU - Wu, Dong-Dong

AU - Ding, Xiang Dong

AU - Wang, Sheng

AU - Wójcik, Jan M.

AU - Zhang, Yi

AU - Tokarska, Małgorzata

AU - Li, Yan

AU - Wang, Ming Shan

AU - Faruque, Omar

AU - Nielsen, Rasmus

AU - Zhang, Qin

AU - Zhang, Ya-Ping

PY - 2018

Y1 - 2018

N2 - Species of the Bos genus, including taurine cattle, zebu, gayal, gaur, banteng, yak, wisent and bison, have been domesticated at least four times and have been an important source of meat, milk and power for many human cultures. We sequence the genomes of gayal, gaur, banteng, wisent and bison, and provide population genomic sequencing of an additional 98 individuals. We use these data to determine the phylogeny and evolutionary history of these species and show that the threatened gayal is an independent species or subspecies. We show that there has been pronounced introgression among different members of this genus, and that it in many cases has involved genes of considerable adaptive importance. For example, genes under domestication selection in cattle (for example, MITF) were introgressed from domestic cattle to yak. Also, genes in the response-to-hypoxia pathway (for example, EGLN1, EGLN2 and HIF3a) have been introgressed from yak to Tibetan cattle, probably facilitating their adaptation to high altitude. We also validate that there is an association between the introgressed EGLN1 allele and haemoglobin and red blood cell concentration. Our results illustrate the importance of introgression as a source of adaptive variation and during domestication, and suggest that the Bos genus evolves as a complex of genetically interconnected species with shared evolutionary trajectories.

AB - Species of the Bos genus, including taurine cattle, zebu, gayal, gaur, banteng, yak, wisent and bison, have been domesticated at least four times and have been an important source of meat, milk and power for many human cultures. We sequence the genomes of gayal, gaur, banteng, wisent and bison, and provide population genomic sequencing of an additional 98 individuals. We use these data to determine the phylogeny and evolutionary history of these species and show that the threatened gayal is an independent species or subspecies. We show that there has been pronounced introgression among different members of this genus, and that it in many cases has involved genes of considerable adaptive importance. For example, genes under domestication selection in cattle (for example, MITF) were introgressed from domestic cattle to yak. Also, genes in the response-to-hypoxia pathway (for example, EGLN1, EGLN2 and HIF3a) have been introgressed from yak to Tibetan cattle, probably facilitating their adaptation to high altitude. We also validate that there is an association between the introgressed EGLN1 allele and haemoglobin and red blood cell concentration. Our results illustrate the importance of introgression as a source of adaptive variation and during domestication, and suggest that the Bos genus evolves as a complex of genetically interconnected species with shared evolutionary trajectories.

U2 - 10.1038/s41559-018-0562-y

DO - 10.1038/s41559-018-0562-y

M3 - Journal article

C2 - 29784979

AN - SCOPUS:85047179716

SN - 2397-334X

VL - 2

SP - 1139

EP - 1145

JO - Nature Ecology & Evolution

JF - Nature Ecology & Evolution

IS - 7

ER -

Pervasive introgression facilitated domestication and adaptation in the Bos species complex

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