Persistent oligemia of rat cerebral cortex in the wake of spreading depression.

TY - JOUR

T1 - Persistent oligemia of rat cerebral cortex in the wake of spreading depression.

AU - Lauritzen, M

AU - Jørgensen, M B

AU - Diemer, N H

AU - Gjedde, A

AU - Hansen, A J

PY - 1982

Y1 - 1982

N2 - Cerebral blood flow during and after spreading depression (SD) was studied in rat brain by quantitative autoradiography. The rise of cortical blood flow during SD was followed by 20 to 25% reduction below normal after SD, lasting at least an hour. Blood flow in th putamen, thalamus, and hippocampus did not change at any time during or after SD. Previous measurements of cerebral blood flow in humans showed that migraine attacks may be accompanied by wavelike spreading oligemia (Olesen et al, 1981). We speculate that the spreading oligemia of migraine may be a phenomenon physiologically related to the present finding of an oligemia after SD.

AB - Cerebral blood flow during and after spreading depression (SD) was studied in rat brain by quantitative autoradiography. The rise of cortical blood flow during SD was followed by 20 to 25% reduction below normal after SD, lasting at least an hour. Blood flow in th putamen, thalamus, and hippocampus did not change at any time during or after SD. Previous measurements of cerebral blood flow in humans showed that migraine attacks may be accompanied by wavelike spreading oligemia (Olesen et al, 1981). We speculate that the spreading oligemia of migraine may be a phenomenon physiologically related to the present finding of an oligemia after SD.

U2 - 10.1002/ana.410120510

DO - 10.1002/ana.410120510

M3 - Journal article

C2 - 7181451

SN - 0364-5134

VL - 12

SP - 469

EP - 474

JO - Annals of Neurology

JF - Annals of Neurology

IS - 5

ER -