Perfusion imaging using rubidium-82 ((82)Rb) PET in rats with myocardial infarction: First small animal cardiac (82)Rb-PET

Andreas Ettrup Clemmensen; Adam Ali Ghotbi; Rasmus Poul Bodholdt; Anne Mette Fisker Hag; Philip Hasbak; Rasmus Sejersten Ripa; Andreas Kjaer

doi:10.1007/s12350-016-0564-6

Perfusion imaging using rubidium-82 ((82)Rb) PET in rats with myocardial infarction: First small animal cardiac (82)Rb-PET

Andreas Ettrup Clemmensen, Adam Ali Ghotbi, Rasmus Poul Bodholdt, Anne Mette Fisker Hag, Philip Hasbak, Rasmus Sejersten Ripa, Andreas Kjaer

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Abstract

Assessing myocardial perfusion using 82Rb-PET is emerging as a valuable clinical tool.1,2 The rapid decay (T½ = 76 s) allows for absolute quantification of both rest and stress perfusion within 30 minutes. In addition to evaluation of epicardial disease with perfusion defects, also evaluation of balanced coronary and small vessel disease is possible. For further evaluation of how 82Rb-PET can be used clinically, pre-clinical application of the method would be valuable. However, so far no data on the use of 82Rb-PET in small animals have been published nor has the use of 82Rb-PET, to the best of our knowledge, been successfully tried. Therefore, we wanted to develop and test the applicability of the method in rats, despite the high positron range of 82Rb. To do so, we adapted the clinical method and tested it in rats with experimentally induced myocardial infarction.

Original language	English
Journal	Journal of Nuclear Cardiology
Volume	24
Issue number	2
Pages (from-to)	750-752
Number of pages	3
ISSN	1071-3581
DOIs	https://doi.org/10.1007/s12350-016-0564-6
Publication status	Published - 1 Apr 2017

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Perfusion imaging using rubidium-82 (82Rb) PET in rats with myocardial infarction: First small animal cardiac 82Rb-PETFinal published version, 751 KBLicence: CC BY

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title = "Perfusion imaging using rubidium-82 ((82)Rb) PET in rats with myocardial infarction: First small animal cardiac (82)Rb-PET",

abstract = "Assessing myocardial perfusion using 82Rb-PET is emerging as a valuable clinical tool.1,2 The rapid decay (T½ = 76 s) allows for absolute quantification of both rest and stress perfusion within 30 minutes. In addition to evaluation of epicardial disease with perfusion defects, also evaluation of balanced coronary and small vessel disease is possible. For further evaluation of how 82Rb-PET can be used clinically, pre-clinical application of the method would be valuable. However, so far no data on the use of 82Rb-PET in small animals have been published nor has the use of 82Rb-PET, to the best of our knowledge, been successfully tried. Therefore, we wanted to develop and test the applicability of the method in rats, despite the high positron range of 82Rb. To do so, we adapted the clinical method and tested it in rats with experimentally induced myocardial infarction.",

author = "Clemmensen, {Andreas Ettrup} and Ghotbi, {Adam Ali} and Bodholdt, {Rasmus Poul} and Hag, {Anne Mette Fisker} and Philip Hasbak and Ripa, {Rasmus Sejersten} and Andreas Kjaer",

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doi = "10.1007/s12350-016-0564-6",

language = "English",

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T1 - Perfusion imaging using rubidium-82 ((82)Rb) PET in rats with myocardial infarction

T2 - First small animal cardiac (82)Rb-PET

AU - Clemmensen, Andreas Ettrup

AU - Ghotbi, Adam Ali

AU - Bodholdt, Rasmus Poul

AU - Hag, Anne Mette Fisker

AU - Hasbak, Philip

AU - Ripa, Rasmus Sejersten

AU - Kjaer, Andreas

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Assessing myocardial perfusion using 82Rb-PET is emerging as a valuable clinical tool.1,2 The rapid decay (T½ = 76 s) allows for absolute quantification of both rest and stress perfusion within 30 minutes. In addition to evaluation of epicardial disease with perfusion defects, also evaluation of balanced coronary and small vessel disease is possible. For further evaluation of how 82Rb-PET can be used clinically, pre-clinical application of the method would be valuable. However, so far no data on the use of 82Rb-PET in small animals have been published nor has the use of 82Rb-PET, to the best of our knowledge, been successfully tried. Therefore, we wanted to develop and test the applicability of the method in rats, despite the high positron range of 82Rb. To do so, we adapted the clinical method and tested it in rats with experimentally induced myocardial infarction.

AB - Assessing myocardial perfusion using 82Rb-PET is emerging as a valuable clinical tool.1,2 The rapid decay (T½ = 76 s) allows for absolute quantification of both rest and stress perfusion within 30 minutes. In addition to evaluation of epicardial disease with perfusion defects, also evaluation of balanced coronary and small vessel disease is possible. For further evaluation of how 82Rb-PET can be used clinically, pre-clinical application of the method would be valuable. However, so far no data on the use of 82Rb-PET in small animals have been published nor has the use of 82Rb-PET, to the best of our knowledge, been successfully tried. Therefore, we wanted to develop and test the applicability of the method in rats, despite the high positron range of 82Rb. To do so, we adapted the clinical method and tested it in rats with experimentally induced myocardial infarction.

U2 - 10.1007/s12350-016-0564-6

DO - 10.1007/s12350-016-0564-6

M3 - Letter

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SN - 1071-3581

VL - 24

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EP - 752

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

IS - 2

ER -

Perfusion imaging using rubidium-82 ((82)Rb) PET in rats with myocardial infarction: First small animal cardiac (82)Rb-PET

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