Peptoid-Peptide hybrid backbone architectures

TY - JOUR

T1 - Peptoid-Peptide hybrid backbone architectures

AU - Olsen, Christian Adam

N1 - Keywords: foldamers, hybrid backbones, medicinal chemistry, peptidomimetics, peptoids

PY - 2010/1/25

Y1 - 2010/1/25

N2 - Peptidomimetic oligomers and foldamers have received considerable attention for over a decade, with β-peptides and the so-called peptoids (N-alkylglycine oligomers) representing prominent examples of such architectures. Lately, hybrid or mixed backbones consisting of both α- and β-amino acids (α/β-peptides) have been investigated in some detail as well. The present Minireview is a survey of the literature concerning hybrid structures of α-amino acids and peptoids, including βpeptoids (N-alkyl-β-alanine oligomers), and is intended to give an overview of this area of research within the field of peptidomimetic science.

AB - Peptidomimetic oligomers and foldamers have received considerable attention for over a decade, with β-peptides and the so-called peptoids (N-alkylglycine oligomers) representing prominent examples of such architectures. Lately, hybrid or mixed backbones consisting of both α- and β-amino acids (α/β-peptides) have been investigated in some detail as well. The present Minireview is a survey of the literature concerning hybrid structures of α-amino acids and peptoids, including βpeptoids (N-alkyl-β-alanine oligomers), and is intended to give an overview of this area of research within the field of peptidomimetic science.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1002/cbic.200900618

DO - 10.1002/cbic.200900618

M3 - Journal article

C2 - 20017179

SN - 1439-4227

VL - 11

SP - 152

EP - 160

JO - ChemBioChem

JF - ChemBioChem

IS - 2

ER -