Pelvic inflammatory disease and risk of invasive ovarian cancer and ovarian borderline tumors

Christina B Rasmussen; Mette T Faber; Allan Jensen; Estrid Høgdall; Claus Høgdall; Jan Blaakær; Susanne K Kjaer

doi:10.1007/s10552-013-0216-y

Pelvic inflammatory disease and risk of invasive ovarian cancer and ovarian borderline tumors

Christina B Rasmussen, Mette T Faber, Allan Jensen, Estrid Høgdall, Claus Høgdall, Jan Blaakær, Susanne K Kjaer

Department of Clinical Medicine

22 Citations (Scopus)

Abstract

Purpose: The aim of the study was to examine the potential association between a history of pelvic inflammatory disease (PID) and risk of epithelial ovarian cancer or ovarian borderline tumors. Methods: In a population-based case-control study in Denmark, we included 554 women with invasive ovarian cancer, 202 with ovarian borderline tumors, and 1,564 controls aged 35-79 years. The analyses were performed in multiple logistic regression models. Results: We found a significantly increased risk of ovarian borderline tumors among women with a history of PID (OR = 1.50; 95 % CI 1.08-2.08) but no apparent association between PID and risk of invasive ovarian cancer (OR = 0.83; 95 % CI 0.65-1.05). We found no effect of age at time of first PID or time since first PID on the risk for either condition. Conclusion: Our results suggest that a history of PID is associated with an increased risk of ovarian borderline tumors, which may support the hypothesis that inflammation is an etiological factor. The lack of an association between previous PID and invasive ovarian cancer may indicate an etiological difference between ovarian borderline tumors and invasive ovarian cancer. However, an important limitation of the study is the use of self-reported PID.

Original language	English
Journal	Cancer causes & control : CCC
Volume	24
Issue number	7
Pages (from-to)	1459-1464
Number of pages	6
ISSN	0957-5243
DOIs	https://doi.org/10.1007/s10552-013-0216-y
Publication status	Published - Jul 2013

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title = "Pelvic inflammatory disease and risk of invasive ovarian cancer and ovarian borderline tumors",

abstract = "Purpose: The aim of the study was to examine the potential association between a history of pelvic inflammatory disease (PID) and risk of epithelial ovarian cancer or ovarian borderline tumors. Methods: In a population-based case-control study in Denmark, we included 554 women with invasive ovarian cancer, 202 with ovarian borderline tumors, and 1,564 controls aged 35-79 years. The analyses were performed in multiple logistic regression models. Results: We found a significantly increased risk of ovarian borderline tumors among women with a history of PID (OR = 1.50; 95 % CI 1.08-2.08) but no apparent association between PID and risk of invasive ovarian cancer (OR = 0.83; 95 % CI 0.65-1.05). We found no effect of age at time of first PID or time since first PID on the risk for either condition. Conclusion: Our results suggest that a history of PID is associated with an increased risk of ovarian borderline tumors, which may support the hypothesis that inflammation is an etiological factor. The lack of an association between previous PID and invasive ovarian cancer may indicate an etiological difference between ovarian borderline tumors and invasive ovarian cancer. However, an important limitation of the study is the use of self-reported PID.",

author = "Rasmussen, {Christina B} and Faber, {Mette T} and Allan Jensen and Estrid H{\o}gdall and Claus H{\o}gdall and Jan Blaak{\ae}r and Kjaer, {Susanne K}",

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doi = "10.1007/s10552-013-0216-y",

language = "English",

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T1 - Pelvic inflammatory disease and risk of invasive ovarian cancer and ovarian borderline tumors

AU - Rasmussen, Christina B

AU - Faber, Mette T

AU - Jensen, Allan

AU - Høgdall, Estrid

AU - Høgdall, Claus

AU - Blaakær, Jan

AU - Kjaer, Susanne K

PY - 2013/7

Y1 - 2013/7

N2 - Purpose: The aim of the study was to examine the potential association between a history of pelvic inflammatory disease (PID) and risk of epithelial ovarian cancer or ovarian borderline tumors. Methods: In a population-based case-control study in Denmark, we included 554 women with invasive ovarian cancer, 202 with ovarian borderline tumors, and 1,564 controls aged 35-79 years. The analyses were performed in multiple logistic regression models. Results: We found a significantly increased risk of ovarian borderline tumors among women with a history of PID (OR = 1.50; 95 % CI 1.08-2.08) but no apparent association between PID and risk of invasive ovarian cancer (OR = 0.83; 95 % CI 0.65-1.05). We found no effect of age at time of first PID or time since first PID on the risk for either condition. Conclusion: Our results suggest that a history of PID is associated with an increased risk of ovarian borderline tumors, which may support the hypothesis that inflammation is an etiological factor. The lack of an association between previous PID and invasive ovarian cancer may indicate an etiological difference between ovarian borderline tumors and invasive ovarian cancer. However, an important limitation of the study is the use of self-reported PID.

AB - Purpose: The aim of the study was to examine the potential association between a history of pelvic inflammatory disease (PID) and risk of epithelial ovarian cancer or ovarian borderline tumors. Methods: In a population-based case-control study in Denmark, we included 554 women with invasive ovarian cancer, 202 with ovarian borderline tumors, and 1,564 controls aged 35-79 years. The analyses were performed in multiple logistic regression models. Results: We found a significantly increased risk of ovarian borderline tumors among women with a history of PID (OR = 1.50; 95 % CI 1.08-2.08) but no apparent association between PID and risk of invasive ovarian cancer (OR = 0.83; 95 % CI 0.65-1.05). We found no effect of age at time of first PID or time since first PID on the risk for either condition. Conclusion: Our results suggest that a history of PID is associated with an increased risk of ovarian borderline tumors, which may support the hypothesis that inflammation is an etiological factor. The lack of an association between previous PID and invasive ovarian cancer may indicate an etiological difference between ovarian borderline tumors and invasive ovarian cancer. However, an important limitation of the study is the use of self-reported PID.

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DO - 10.1007/s10552-013-0216-y

M3 - Journal article

C2 - 23615817

SN - 0957-5243

VL - 24

SP - 1459

EP - 1464

JO - Cancer causes & control : CCC

JF - Cancer causes & control : CCC

IS - 7

ER -

Pelvic inflammatory disease and risk of invasive ovarian cancer and ovarian borderline tumors

Abstract

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