Pattern of contact sensitization in patients with and without atopic dermatitis in a hospital-based clinical database

TY - JOUR

T1 - Pattern of contact sensitization in patients with and without atopic dermatitis in a hospital-based clinical database

AU - Clemmensen, Kim Katrine Bjerring

AU - Thomsen, Simon Francis

AU - Jemec, Gregor Borut Ernst

AU - Agner, Tove

N1 - © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2014/8

Y1 - 2014/8

N2 - BACKGROUND: Both atopic dermatitis and contact sensitization are common conditions; however, a definite understanding of the relationship between contact sensitization and atopic dermatitis has not been reached.OBJECTIVES: In this descriptive study, we investigated the differences between positive patch test reactions in patients with and without atopic dermatitis in a patch test cohort, and explored the influence of disease severity.PATIENTS/MATERIALS/METHODS: Patch test results, information on atopic dermatitis and demographic variables were taken from a database, including all patients patch tested at Bispebjerg and Roskilde Hospitals from January 2009 to January 2013. Severe atopic dermatitis was defined as systemic therapy or hospitalization resulting from atopic dermatitis. All other patients with atopic dermatitis were defined as having mild/moderate disease.RESULTS: The study included 2221 patients: 293 patients with atopic dermatitis and 1928 without. Forty-one per cent of patients with and 46.2% of patients without atopic dermatitis had at least one positive patch test reaction (p = 0.092). More patients with severe atopic dermatitis than patients with non-severe atopic dermatitis had multiple positive patch test reactions (19.4% versus 10.0%, p = 0.046).CONCLUSIONS: Overall, we found similar frequencies of positive patch test reactions in patients with and without atopic dermatitis. However, a higher frequency of multiple sensitizations was found in patients with severe atopic dermatitis.

AB - BACKGROUND: Both atopic dermatitis and contact sensitization are common conditions; however, a definite understanding of the relationship between contact sensitization and atopic dermatitis has not been reached.OBJECTIVES: In this descriptive study, we investigated the differences between positive patch test reactions in patients with and without atopic dermatitis in a patch test cohort, and explored the influence of disease severity.PATIENTS/MATERIALS/METHODS: Patch test results, information on atopic dermatitis and demographic variables were taken from a database, including all patients patch tested at Bispebjerg and Roskilde Hospitals from January 2009 to January 2013. Severe atopic dermatitis was defined as systemic therapy or hospitalization resulting from atopic dermatitis. All other patients with atopic dermatitis were defined as having mild/moderate disease.RESULTS: The study included 2221 patients: 293 patients with atopic dermatitis and 1928 without. Forty-one per cent of patients with and 46.2% of patients without atopic dermatitis had at least one positive patch test reaction (p = 0.092). More patients with severe atopic dermatitis than patients with non-severe atopic dermatitis had multiple positive patch test reactions (19.4% versus 10.0%, p = 0.046).CONCLUSIONS: Overall, we found similar frequencies of positive patch test reactions in patients with and without atopic dermatitis. However, a higher frequency of multiple sensitizations was found in patients with severe atopic dermatitis.

KW - Adult

KW - Allergens

KW - Databases as Topic

KW - Denmark

KW - Dermatitis, Allergic Contact

KW - Dermatitis, Atopic

KW - Dermatitis, Occupational

KW - Facial Dermatoses

KW - Female

KW - Hand Dermatoses

KW - Hospitals

KW - Humans

KW - Leg Dermatoses

KW - Male

KW - Patch Tests

KW - Severity of Illness Index

U2 - 10.1111/cod.12229

DO - 10.1111/cod.12229

M3 - Journal article

C2 - 24697272

SN - 0105-1873

VL - 71

SP - 75

EP - 81

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 2

ER -