Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2) detects significantly more contact allerg

Ann Pontén; Kristiina Aalto-Korte; Tove Agner; Klaus Ejner Andersen; Ana M Giménez-Arnau; Margarida Gonçalo; An Goossens; Jeanne D Johansen; Christophe J Le Coz; Howard I Maibach; Thomas Rustemeyer; Ian R White; Magnus Bruze

doi:10.1111/j.1600-0536.2012.02169.x

Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2) detects significantly more contact allerg

Ann Pontén, Kristiina Aalto-Korte, Tove Agner, Klaus Ejner Andersen, Ana M Giménez-Arnau, Margarida Gonçalo, An Goossens, Jeanne D Johansen, Christophe J Le Coz, Howard I Maibach, Thomas Rustemeyer, Ian R White, Magnus Bruze

21 Citations (Scopus)

Abstract

Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm ²) and 1.0% (wt/vol) (0.30 mg/cm²) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p < 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.

Original language	English
Journal	Contact Dermatitis
Volume	68
Issue number	1
Pages (from-to)	50-53
Number of pages	4
ISSN	0105-1873
DOIs	https://doi.org/10.1111/j.1600-0536.2012.02169.x
Publication status	Published - Jan 2013

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Pontén, A., Aalto-Korte, K., Agner, T., Andersen, K. E., Giménez-Arnau, A. M., Gonçalo, M., Goossens, A., Johansen, J. D., Le Coz, C. J., Maibach, H. I., Rustemeyer, T., White, I. R., & Bruze, M. (2013). Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2) detects significantly more contact allerg. Contact Dermatitis, 68(1), 50-53. https://doi.org/10.1111/j.1600-0536.2012.02169.x

Pontén, A, Aalto-Korte, K, Agner, T, Andersen, KE, Giménez-Arnau, AM, Gonçalo, M, Goossens, A, Johansen, JD, Le Coz, CJ, Maibach, HI, Rustemeyer, T, White, IR & Bruze, M 2013, 'Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2) detects significantly more contact allerg', Contact Dermatitis, vol. 68, no. 1, pp. 50-53. https://doi.org/10.1111/j.1600-0536.2012.02169.x

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title = "Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2) detects significantly more contact allerg",

abstract = "Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm 2) and 1.0% (wt/vol) (0.30 mg/cm2) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p < 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.",

author = "Ann Pont{\'e}n and Kristiina Aalto-Korte and Tove Agner and Andersen, {Klaus Ejner} and Gim{\'e}nez-Arnau, {Ana M} and Margarida Gon{\c c}alo and An Goossens and Johansen, {Jeanne D} and {Le Coz}, {Christophe J} and Maibach, {Howard I} and Thomas Rustemeyer and White, {Ian R} and Magnus Bruze",

year = "2013",

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doi = "10.1111/j.1600-0536.2012.02169.x",

language = "English",

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T1 - Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2) detects significantly more contact allerg

AU - Pontén, Ann

AU - Aalto-Korte, Kristiina

AU - Agner, Tove

AU - Andersen, Klaus Ejner

AU - Giménez-Arnau, Ana M

AU - Gonçalo, Margarida

AU - Goossens, An

AU - Johansen, Jeanne D

AU - Le Coz, Christophe J

AU - Maibach, Howard I

AU - Rustemeyer, Thomas

AU - White, Ian R

AU - Bruze, Magnus

PY - 2013/1

Y1 - 2013/1

N2 - Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm 2) and 1.0% (wt/vol) (0.30 mg/cm2) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p < 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.

AB - Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm 2) and 1.0% (wt/vol) (0.30 mg/cm2) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p < 0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.

U2 - 10.1111/j.1600-0536.2012.02169.x

DO - 10.1111/j.1600-0536.2012.02169.x

M3 - Journal article

C2 - 23035891

SN - 0105-1873

VL - 68

SP - 50

EP - 53

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 1

ER -

Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2) detects significantly more contact allerg

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