Partial volume effect (PVE) on the arterial input function (AIF) in T1-weighted perfusion imaging and limitations of the multiplicative rescaling approach

TY - JOUR

T1 - Partial volume effect (PVE) on the arterial input function (AIF) in T1-weighted perfusion imaging and limitations of the multiplicative rescaling approach

AU - Hansen, Adam Espe

AU - Pedersen, Henrik

AU - Rostrup, Egill

AU - Larsson, Henrik B W

AU - Hansen, Adam E

AU - Pedersen, Henrik

AU - Rostrup, Egill

AU - Larsson, Henrik B W

N1 - Keywords: Algorithms; Artifacts; Brain; Cerebrovascular Circulation; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Angiography; Reproducibility of Results; Sensitivity and Specificity

PY - 2009

Y1 - 2009

N2 - The partial volume effect (PVE) on the arterial input function (AIF) remains a major obstacle to absolute quantification of cerebral blood flow (CBF) using MRI. This study evaluates the validity and performance of a commonly used multiplicative rescaling of the AIF to correct for the PVE. In a group of six patients, perfusion imaging was performed using a T(1)-weighted approach that minimizes confounding susceptibility artifacts. Various degrees of PVE were induced on the AIF and subsequently corrected using four different schemes of multiplicative AIF rescaling. Our results show that a multiplicative rescaling is not always applicable and can introduce a CBF bias. An easily measurable quantity denoted the tissue signal fraction (TSF) is proposed as a measure of the applicability of a multiplicative rescaling. For the present CBF quantification method, a TSF of <0.4 results in a CBF bias <15% after AIF rescaling.

AB - The partial volume effect (PVE) on the arterial input function (AIF) remains a major obstacle to absolute quantification of cerebral blood flow (CBF) using MRI. This study evaluates the validity and performance of a commonly used multiplicative rescaling of the AIF to correct for the PVE. In a group of six patients, perfusion imaging was performed using a T(1)-weighted approach that minimizes confounding susceptibility artifacts. Various degrees of PVE were induced on the AIF and subsequently corrected using four different schemes of multiplicative AIF rescaling. Our results show that a multiplicative rescaling is not always applicable and can introduce a CBF bias. An easily measurable quantity denoted the tissue signal fraction (TSF) is proposed as a measure of the applicability of a multiplicative rescaling. For the present CBF quantification method, a TSF of <0.4 results in a CBF bias <15% after AIF rescaling.

U2 - 10.1002/mrm.22098

DO - 10.1002/mrm.22098

M3 - Journal article

C2 - 19672948

SN - 0740-3194

VL - 62

SP - 1055

EP - 1059

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 4

ER -