TY - JOUR
T1 - Parathyroid hormone and vitamin D--markers for cardiovascular and all cause mortality in heart failure
AU - Schierbeck, Louise Lind
AU - Jensen, Torben Slott
AU - Bang, Ulrich
AU - Jensen, Gorm
AU - Køber, Lars
AU - Jensen, Jens-Erik Beck
PY - 2011/6
Y1 - 2011/6
N2 - AimsTo investigate levels of vitamin D and parathyroid hormone (PTH) in a population of heart failure (HF) patients, and to evaluate whether vitamin D and PTH are related to prognosis.Methods and resultsThis was a prospective study of 148 HF outpatients (mean age 68 years, 102 men) with follow-up for mortality after 3 years. Levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), PTH, 25-hydroxyvitamin D (25-OHD), and several other biomarkers were examined. Mortality and cardiovascular mortality were analysed in multivariable regression analyses adjusting for other independent prognostic variables. Vitamin D deficiency (≤50 nmol/L) was prevalent in 43 of the population; 26 had elevated PTH levels; none had primary hyperparathyroidism. We found a strong and independent significant association of both PTH and vitamin D to mortality, which was independent of other clinically important parameters [NT-proBNP, estimated glomerular filtration rate (eGFR), age, and left ventricular ejection fraction (LVEF)]. Both PTH and vitamin D were also significantly associated with all cause mortality. In an adjusted model, we found a hazard ratio of 1.9 (confidence interval 1.13.4) for vitamin D deficiency and 2.0 (1.03.8) for the upper median of PTH, respectively.ConclusionIn this relatively small prospective study, PTH and vitamin D were independently associated with all cause and cardiovascular mortality in patients with HF. This was independent of other known risk factors such as eGFR, LVEF, NT-proBNP, and age.
AB - AimsTo investigate levels of vitamin D and parathyroid hormone (PTH) in a population of heart failure (HF) patients, and to evaluate whether vitamin D and PTH are related to prognosis.Methods and resultsThis was a prospective study of 148 HF outpatients (mean age 68 years, 102 men) with follow-up for mortality after 3 years. Levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), PTH, 25-hydroxyvitamin D (25-OHD), and several other biomarkers were examined. Mortality and cardiovascular mortality were analysed in multivariable regression analyses adjusting for other independent prognostic variables. Vitamin D deficiency (≤50 nmol/L) was prevalent in 43 of the population; 26 had elevated PTH levels; none had primary hyperparathyroidism. We found a strong and independent significant association of both PTH and vitamin D to mortality, which was independent of other clinically important parameters [NT-proBNP, estimated glomerular filtration rate (eGFR), age, and left ventricular ejection fraction (LVEF)]. Both PTH and vitamin D were also significantly associated with all cause mortality. In an adjusted model, we found a hazard ratio of 1.9 (confidence interval 1.13.4) for vitamin D deficiency and 2.0 (1.03.8) for the upper median of PTH, respectively.ConclusionIn this relatively small prospective study, PTH and vitamin D were independently associated with all cause and cardiovascular mortality in patients with HF. This was independent of other known risk factors such as eGFR, LVEF, NT-proBNP, and age.
U2 - 10.1093/eurjhf/hfr016
DO - 10.1093/eurjhf/hfr016
M3 - Journal article
SN - 1567-4215
VL - 13
SP - 626
EP - 632
JO - European Journal of Heart Failure, Supplement
JF - European Journal of Heart Failure, Supplement
IS - 6
ER -