Oxidized limonene and oxidized linalool - concomitant contact allergy to common fragrance terpenes

TY - JOUR

T1 - Oxidized limonene and oxidized linalool - concomitant contact allergy to common fragrance terpenes

AU - Bråred Christensson, Johanna

AU - Karlberg, Ann-Therese

AU - Andersen, Klaus E

AU - Bruze, Magnus

AU - Johansen, Jeanne Duus

AU - Garcia-Bravo, Begoña

AU - Giménez Arnau, Ana

AU - Goh, Chee-Leok

AU - Nixon, Rosemary

AU - White, Ian R

N1 - © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Summary Background Limonene and linalool are common fragrance terpenes. Both oxidized R-limonene and oxidized linalool have recently been patch tested in an international setting, showing contact allergy in 5.2% and 6.9% of dermatitis patients, respectively. Objective To investigate concomitant reactions between oxidized R-limonene and oxidized linalool in consecutive dermatitis patients. Methods Oxidized R-limonene 3.0% (containing limonene hydroperoxides 0.33%) and oxidized linalool 6% (linalool hydroperoxides 1%) in petrolatum were tested in 2900 consecutive dermatitis patients in Australia, Denmark, Singapore, Spain, Sweden, and the United Kingdom. Results A total of 281 patients reacted to either oxidized R-limonene or oxidized linalool. Of these, 25% had concomitant reactions to both compounds, whereas 29% reacted only to oxidized R-limonene and 46% only to oxidized linalool. Of the 152 patients reacting to oxidized R-limonene, 46% reacted to oxidized linalool, whereas 35% of the 200 patients reacting to oxidized linalool also reacted to oxidized R-limonene. Conclusions The majority of the patients (75%) reacted to only one of the oxidation mixtures, thus supporting the specificity of the reactions. The concomitant reactions to the two fragrance allergens suggest multiple sensitizations, which most likely reflect the exposure to the different fragrance materials in various types of consumer products. This is in accordance with what is generally seen for patch test reactions to fragrance materials.

AB - Summary Background Limonene and linalool are common fragrance terpenes. Both oxidized R-limonene and oxidized linalool have recently been patch tested in an international setting, showing contact allergy in 5.2% and 6.9% of dermatitis patients, respectively. Objective To investigate concomitant reactions between oxidized R-limonene and oxidized linalool in consecutive dermatitis patients. Methods Oxidized R-limonene 3.0% (containing limonene hydroperoxides 0.33%) and oxidized linalool 6% (linalool hydroperoxides 1%) in petrolatum were tested in 2900 consecutive dermatitis patients in Australia, Denmark, Singapore, Spain, Sweden, and the United Kingdom. Results A total of 281 patients reacted to either oxidized R-limonene or oxidized linalool. Of these, 25% had concomitant reactions to both compounds, whereas 29% reacted only to oxidized R-limonene and 46% only to oxidized linalool. Of the 152 patients reacting to oxidized R-limonene, 46% reacted to oxidized linalool, whereas 35% of the 200 patients reacting to oxidized linalool also reacted to oxidized R-limonene. Conclusions The majority of the patients (75%) reacted to only one of the oxidation mixtures, thus supporting the specificity of the reactions. The concomitant reactions to the two fragrance allergens suggest multiple sensitizations, which most likely reflect the exposure to the different fragrance materials in various types of consumer products. This is in accordance with what is generally seen for patch test reactions to fragrance materials.

KW - Australia

KW - Cohort Studies

KW - Cyclohexenes

KW - Denmark

KW - Dermatitis, Allergic Contact

KW - Humans

KW - Monoterpenes

KW - Oxidation-Reduction

KW - Patch Tests

KW - Perfume

KW - Singapore

KW - Spain

KW - Sweden

KW - Terpenes

KW - United Kingdom

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/cod.12545

DO - 10.1111/cod.12545

M3 - Journal article

C2 - 26918793

SN - 0105-1873

VL - 74

SP - 273

EP - 280

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 5

ER -