Overcoming Treatment Toxicity through Sequential Therapy

TY - JOUR

T1 - Overcoming Treatment Toxicity through Sequential Therapy

AU - Benada, Jan

AU - Ejlertsen, Bent

AU - Sørensen, Claus Storgaard

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/6/10

Y1 - 2019/6/10

N2 - Combined inhibitions of PARP and DNA damage checkpoint have the potential for high anti-cancer efficacy, but concurrent inhibitions have been hampered by intolerable side effects. In this issue of Cancer Cell, Fang and colleagues (Fang et al., 2019) propose that sequential inhibitions of PARP and DNA damage checkpoint considerably widen the therapeutic window.

AB - Combined inhibitions of PARP and DNA damage checkpoint have the potential for high anti-cancer efficacy, but concurrent inhibitions have been hampered by intolerable side effects. In this issue of Cancer Cell, Fang and colleagues (Fang et al., 2019) propose that sequential inhibitions of PARP and DNA damage checkpoint considerably widen the therapeutic window.

U2 - 10.1016/j.ccell.2019.05.006

DO - 10.1016/j.ccell.2019.05.006

M3 - Journal article

C2 - 31185206

SN - 1535-6108

VL - 35

SP - 821

EP - 822

JO - Cancer Cell

JF - Cancer Cell

IS - 6

ER -