Overcoming foetal motion using interactive real-time magnetic resonance imaging

Lau Brix; Steffen Ringgaard; Puk Sandager; Olav Bjørn Petersen; Thomas Sangild Sørensen; Erik Lundorf; Brian Stausbøl-Grøn

doi:10.1111/cpf.12364

Overcoming foetal motion using interactive real-time magnetic resonance imaging

Lau Brix, Steffen Ringgaard, Puk Sandager, Olav Bjørn Petersen, Thomas Sangild Sørensen, Erik Lundorf, Brian Stausbøl-Grøn

1 Citation (Scopus)

Abstract

OBJECTIVE: Foetal MRI has become an established image modality in the prenatal diagnosis of CNS anomalies, but image quality can be severely affected by foetal movements. The objective was to overcome these inherent motion problems by applying interactive real-time MRI and to evaluate the diagnostic usefulness of the applied real-time MRI sequence in relation to standard protocols.

METHODS: Ten healthy foetuses (gestation week 21·3 ± 0·5) were scanned using a system, which allowed visual feedback and interactive slice positioning in real time. The data were compared to a control group of 14 healthy foetuses (gestation week 21·0 ± 0·8) who had previously been scanned using standard MRI. Comparisons were carried out by two radiologists with regard to cerebral anthropometric sizes, presence of important brain structures, degree of movement, clinical image value, image quality and ability to obtain correct slice planes.

RESULTS: Two out of eight anthropometric sizes were statistically different between the two groups. Representation of cerebral structures was found in 70-100% in the real-time group. No statistically differences were found in clinical image value and image quality. The mean ability to obtain optimal slice planes was higher in the real-time group, but it was not significant.

CONCLUSION: Imaging of the foetal brain using the proposed interactive real-time MRI system is a promising alternative to traditional foetal MRI for anthropometrics or as a supplement for the representation of foetal brain structures in cases in which foetal motion causes challenges in relation to obtaining optimal slice planes using conventional MRI techniques.

Original language	English
Journal	Clinical Physiology and Functional Imaging
Volume	37
Issue number	6
Pages (from-to)	717-722
ISSN	1475-0961
DOIs	https://doi.org/10.1111/cpf.12364
Publication status	Published - Nov 2017
Externally published	Yes

Keywords

Adult
Artifacts
Brain/diagnostic imaging
Cephalometry/methods
Female
Fetal Development
Fetus/diagnostic imaging
Gestational Age
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging
Movement
Predictive Value of Tests
Pregnancy
Prenatal Diagnosis/methods
Reproducibility of Results
Retrospective Studies
Time Factors
Young Adult

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10.1111/cpf.12364

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@article{a3e806cf96b040b5bc73e6b593aced5f,

title = "Overcoming foetal motion using interactive real-time magnetic resonance imaging",

abstract = "OBJECTIVE: Foetal MRI has become an established image modality in the prenatal diagnosis of CNS anomalies, but image quality can be severely affected by foetal movements. The objective was to overcome these inherent motion problems by applying interactive real-time MRI and to evaluate the diagnostic usefulness of the applied real-time MRI sequence in relation to standard protocols.METHODS: Ten healthy foetuses (gestation week 21·3 ± 0·5) were scanned using a system, which allowed visual feedback and interactive slice positioning in real time. The data were compared to a control group of 14 healthy foetuses (gestation week 21·0 ± 0·8) who had previously been scanned using standard MRI. Comparisons were carried out by two radiologists with regard to cerebral anthropometric sizes, presence of important brain structures, degree of movement, clinical image value, image quality and ability to obtain correct slice planes.RESULTS: Two out of eight anthropometric sizes were statistically different between the two groups. Representation of cerebral structures was found in 70-100% in the real-time group. No statistically differences were found in clinical image value and image quality. The mean ability to obtain optimal slice planes was higher in the real-time group, but it was not significant.CONCLUSION: Imaging of the foetal brain using the proposed interactive real-time MRI system is a promising alternative to traditional foetal MRI for anthropometrics or as a supplement for the representation of foetal brain structures in cases in which foetal motion causes challenges in relation to obtaining optimal slice planes using conventional MRI techniques.",

keywords = "Adult, Artifacts, Brain/diagnostic imaging, Cephalometry/methods, Female, Fetal Development, Fetus/diagnostic imaging, Gestational Age, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Movement, Predictive Value of Tests, Pregnancy, Prenatal Diagnosis/methods, Reproducibility of Results, Retrospective Studies, Time Factors, Young Adult",

author = "Lau Brix and Steffen Ringgaard and Puk Sandager and Petersen, {Olav Bj{\o}rn} and S{\o}rensen, {Thomas Sangild} and Erik Lundorf and Brian Stausb{\o}l-Gr{\o}n",

note = "{\textcopyright} 2016 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.",

year = "2017",

month = nov,

doi = "10.1111/cpf.12364",

language = "English",

volume = "37",

pages = "717--722",

journal = "Clinical Physiology and Functional Imaging",

issn = "1475-0961",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - Overcoming foetal motion using interactive real-time magnetic resonance imaging

AU - Brix, Lau

AU - Ringgaard, Steffen

AU - Sandager, Puk

AU - Petersen, Olav Bjørn

AU - Sørensen, Thomas Sangild

AU - Lundorf, Erik

AU - Stausbøl-Grøn, Brian

PY - 2017/11

Y1 - 2017/11

N2 - OBJECTIVE: Foetal MRI has become an established image modality in the prenatal diagnosis of CNS anomalies, but image quality can be severely affected by foetal movements. The objective was to overcome these inherent motion problems by applying interactive real-time MRI and to evaluate the diagnostic usefulness of the applied real-time MRI sequence in relation to standard protocols.METHODS: Ten healthy foetuses (gestation week 21·3 ± 0·5) were scanned using a system, which allowed visual feedback and interactive slice positioning in real time. The data were compared to a control group of 14 healthy foetuses (gestation week 21·0 ± 0·8) who had previously been scanned using standard MRI. Comparisons were carried out by two radiologists with regard to cerebral anthropometric sizes, presence of important brain structures, degree of movement, clinical image value, image quality and ability to obtain correct slice planes.RESULTS: Two out of eight anthropometric sizes were statistically different between the two groups. Representation of cerebral structures was found in 70-100% in the real-time group. No statistically differences were found in clinical image value and image quality. The mean ability to obtain optimal slice planes was higher in the real-time group, but it was not significant.CONCLUSION: Imaging of the foetal brain using the proposed interactive real-time MRI system is a promising alternative to traditional foetal MRI for anthropometrics or as a supplement for the representation of foetal brain structures in cases in which foetal motion causes challenges in relation to obtaining optimal slice planes using conventional MRI techniques.

AB - OBJECTIVE: Foetal MRI has become an established image modality in the prenatal diagnosis of CNS anomalies, but image quality can be severely affected by foetal movements. The objective was to overcome these inherent motion problems by applying interactive real-time MRI and to evaluate the diagnostic usefulness of the applied real-time MRI sequence in relation to standard protocols.METHODS: Ten healthy foetuses (gestation week 21·3 ± 0·5) were scanned using a system, which allowed visual feedback and interactive slice positioning in real time. The data were compared to a control group of 14 healthy foetuses (gestation week 21·0 ± 0·8) who had previously been scanned using standard MRI. Comparisons were carried out by two radiologists with regard to cerebral anthropometric sizes, presence of important brain structures, degree of movement, clinical image value, image quality and ability to obtain correct slice planes.RESULTS: Two out of eight anthropometric sizes were statistically different between the two groups. Representation of cerebral structures was found in 70-100% in the real-time group. No statistically differences were found in clinical image value and image quality. The mean ability to obtain optimal slice planes was higher in the real-time group, but it was not significant.CONCLUSION: Imaging of the foetal brain using the proposed interactive real-time MRI system is a promising alternative to traditional foetal MRI for anthropometrics or as a supplement for the representation of foetal brain structures in cases in which foetal motion causes challenges in relation to obtaining optimal slice planes using conventional MRI techniques.

KW - Adult

KW - Artifacts

KW - Brain/diagnostic imaging

KW - Cephalometry/methods

KW - Female

KW - Fetal Development

KW - Fetus/diagnostic imaging

KW - Gestational Age

KW - Humans

KW - Image Interpretation, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Movement

KW - Predictive Value of Tests

KW - Pregnancy

KW - Prenatal Diagnosis/methods

KW - Reproducibility of Results

KW - Retrospective Studies

KW - Time Factors

KW - Young Adult

U2 - 10.1111/cpf.12364

DO - 10.1111/cpf.12364

M3 - Journal article

C2 - 27005484

SN - 1475-0961

VL - 37

SP - 717

EP - 722

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

IS - 6

ER -

Overcoming foetal motion using interactive real-time magnetic resonance imaging

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Keywords

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