Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries - compilation of 20 years of multicenter experience

Kenny A Rodriguez-Wallberg; Tom Tanbo; Helena Tinkanen; Ann Thurin-Kjellberg; Elizabeth Nedstrand; Margareta Laczna Kitlinski; Erik Ernst; Jens Fedder; Aila Tiitinen; Laure Morin-Papunen; Snorri Einarsson; Varpu Jokimaa; Maritta Hippeläinen; Mikael Lood; Johannes Gudmundsson; Jan I Olofsson; Claus Yding Andersen

doi:10.1111/aogs.12934

Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries - compilation of 20 years of multicenter experience

Kenny A Rodriguez-Wallberg, Tom Tanbo, Helena Tinkanen, Ann Thurin-Kjellberg, Elizabeth Nedstrand, Margareta Laczna Kitlinski, Erik Ernst, Jens Fedder, Aila Tiitinen, Laure Morin-Papunen, Snorri Einarsson, Varpu Jokimaa, Maritta Hippeläinen, Mikael Lood, Johannes Gudmundsson, Jan I Olofsson, Claus Yding Andersen

Department of Clinical Medicine

54 Citations (Scopus)

Abstract

INTRODUCTION: The aim of this study is to report the current status of ovarian tissue cryopreservation among alternatives for fertility preservation in the Nordic countries.

MATERIAL AND METHODS: A questionnaire was sent to 14 Nordic academic reproductive centers with established fertility preservation programs. It covered fertility preservation cases performed up to December 2014, standard procedures for ovarian tissue cryopreservation and oocyte cryopreservation and reproductive outcomes following ovarian tissue transplantation.

RESULTS: Among the Nordic countries, Denmark and Norway practice ovarian tissue cryopreservation as a clinical treatment (822 and 164 cases, respectively) and their programs are centralized. In Sweden (457 cases), ovarian tissue cryopreservation is practiced at five of six centers and in Finland at all five centers (145 cases). Nearly all considered ovarian tissue cryopreservation to be experimental. In Iceland, embryo cryopreservation is the only option for fertility preservation. Most centers use slow-freezing methods for ovarian tissue cryopreservation. Most patients selected for ovarian tissue cryopreservation were newly diagnosed with cancer and the tissue was predominantly retrieved laparoscopically by unilateral oophorectomy. Only minor complications were reported. In total, 46 women have undergone ovarian tissue transplantation aiming at recovering fertility, 17 healthy children have been born and several additional pregnancies are currently ongoing. Whenever patients' clinical condition is permissive, oocyte cryopreservation after hormonal stimulation is preferred for fertility preservation. Between 2012 and 2014, a smaller proportion of females have undergone fertility preservation in the Nordic centers, in comparison to males (1:3).

CONCLUSIONS: Overall, ovarian tissue cryopreservation was reported to be safe. Slow freezing methods are still preferred. Promising results of recovery of fertility have been reported in Nordic countries that have initiated ovarian tissue transplantation procedures.

Original language	English
Journal	Acta Obstetricia et Gynecologica Scandinavica
Volume	95
Issue number	9
Pages (from-to)	1015-1026
Number of pages	12
ISSN	0001-6349
DOIs	https://doi.org/10.1111/aogs.12934
Publication status	Published - 1 Sept 2016

Keywords

Cryopreservation
Embryo, Mammalian
Female
Fertility Preservation
Hospitals, University
Humans
Oocytes
Ovary
Scandinavian and Nordic Countries
Surveys and Questionnaires
Journal Article
Multicenter Study

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/aogs.12934Licence: CC BY-NC-ND

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Rodriguez-Wallberg, K. A., Tanbo, T., Tinkanen, H., Thurin-Kjellberg, A., Nedstrand, E., Kitlinski, M. L., Ernst, E., Fedder, J., Tiitinen, A., Morin-Papunen, L., Einarsson, S., Jokimaa, V., Hippeläinen, M., Lood, M., Gudmundsson, J., Olofsson, J. I., & Andersen, C. Y. (2016). Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries - compilation of 20 years of multicenter experience. Acta Obstetricia et Gynecologica Scandinavica, 95(9), 1015-1026. https://doi.org/10.1111/aogs.12934

Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries - compilation of 20 years of multicenter experience. / Rodriguez-Wallberg, Kenny A; Tanbo, Tom; Tinkanen, Helena et al.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 95, No. 9, 01.09.2016, p. 1015-1026.

Research output: Contribution to journal › Journal article › Research › peer-review

Rodriguez-Wallberg, KA, Tanbo, T, Tinkanen, H, Thurin-Kjellberg, A, Nedstrand, E, Kitlinski, ML, Ernst, E, Fedder, J, Tiitinen, A, Morin-Papunen, L, Einarsson, S, Jokimaa, V, Hippeläinen, M, Lood, M, Gudmundsson, J, Olofsson, JI & Andersen, CY 2016, 'Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries - compilation of 20 years of multicenter experience', Acta Obstetricia et Gynecologica Scandinavica, vol. 95, no. 9, pp. 1015-1026. https://doi.org/10.1111/aogs.12934

Rodriguez-Wallberg KA, Tanbo T, Tinkanen H, Thurin-Kjellberg A, Nedstrand E, Kitlinski ML et al. Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries - compilation of 20 years of multicenter experience. Acta Obstetricia et Gynecologica Scandinavica. 2016 Sept 1;95(9):1015-1026. doi: 10.1111/aogs.12934

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abstract = "INTRODUCTION: The aim of this study is to report the current status of ovarian tissue cryopreservation among alternatives for fertility preservation in the Nordic countries.MATERIAL AND METHODS: A questionnaire was sent to 14 Nordic academic reproductive centers with established fertility preservation programs. It covered fertility preservation cases performed up to December 2014, standard procedures for ovarian tissue cryopreservation and oocyte cryopreservation and reproductive outcomes following ovarian tissue transplantation.RESULTS: Among the Nordic countries, Denmark and Norway practice ovarian tissue cryopreservation as a clinical treatment (822 and 164 cases, respectively) and their programs are centralized. In Sweden (457 cases), ovarian tissue cryopreservation is practiced at five of six centers and in Finland at all five centers (145 cases). Nearly all considered ovarian tissue cryopreservation to be experimental. In Iceland, embryo cryopreservation is the only option for fertility preservation. Most centers use slow-freezing methods for ovarian tissue cryopreservation. Most patients selected for ovarian tissue cryopreservation were newly diagnosed with cancer and the tissue was predominantly retrieved laparoscopically by unilateral oophorectomy. Only minor complications were reported. In total, 46 women have undergone ovarian tissue transplantation aiming at recovering fertility, 17 healthy children have been born and several additional pregnancies are currently ongoing. Whenever patients' clinical condition is permissive, oocyte cryopreservation after hormonal stimulation is preferred for fertility preservation. Between 2012 and 2014, a smaller proportion of females have undergone fertility preservation in the Nordic centers, in comparison to males (1:3).CONCLUSIONS: Overall, ovarian tissue cryopreservation was reported to be safe. Slow freezing methods are still preferred. Promising results of recovery of fertility have been reported in Nordic countries that have initiated ovarian tissue transplantation procedures.",

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T1 - Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries - compilation of 20 years of multicenter experience

AU - Rodriguez-Wallberg, Kenny A

AU - Tanbo, Tom

AU - Tinkanen, Helena

AU - Thurin-Kjellberg, Ann

AU - Nedstrand, Elizabeth

AU - Kitlinski, Margareta Laczna

AU - Ernst, Erik

AU - Fedder, Jens

AU - Tiitinen, Aila

AU - Morin-Papunen, Laure

AU - Einarsson, Snorri

AU - Jokimaa, Varpu

AU - Hippeläinen, Maritta

AU - Lood, Mikael

AU - Gudmundsson, Johannes

AU - Olofsson, Jan I

AU - Andersen, Claus Yding

PY - 2016/9/1

Y1 - 2016/9/1

N2 - INTRODUCTION: The aim of this study is to report the current status of ovarian tissue cryopreservation among alternatives for fertility preservation in the Nordic countries.MATERIAL AND METHODS: A questionnaire was sent to 14 Nordic academic reproductive centers with established fertility preservation programs. It covered fertility preservation cases performed up to December 2014, standard procedures for ovarian tissue cryopreservation and oocyte cryopreservation and reproductive outcomes following ovarian tissue transplantation.RESULTS: Among the Nordic countries, Denmark and Norway practice ovarian tissue cryopreservation as a clinical treatment (822 and 164 cases, respectively) and their programs are centralized. In Sweden (457 cases), ovarian tissue cryopreservation is practiced at five of six centers and in Finland at all five centers (145 cases). Nearly all considered ovarian tissue cryopreservation to be experimental. In Iceland, embryo cryopreservation is the only option for fertility preservation. Most centers use slow-freezing methods for ovarian tissue cryopreservation. Most patients selected for ovarian tissue cryopreservation were newly diagnosed with cancer and the tissue was predominantly retrieved laparoscopically by unilateral oophorectomy. Only minor complications were reported. In total, 46 women have undergone ovarian tissue transplantation aiming at recovering fertility, 17 healthy children have been born and several additional pregnancies are currently ongoing. Whenever patients' clinical condition is permissive, oocyte cryopreservation after hormonal stimulation is preferred for fertility preservation. Between 2012 and 2014, a smaller proportion of females have undergone fertility preservation in the Nordic centers, in comparison to males (1:3).CONCLUSIONS: Overall, ovarian tissue cryopreservation was reported to be safe. Slow freezing methods are still preferred. Promising results of recovery of fertility have been reported in Nordic countries that have initiated ovarian tissue transplantation procedures.

AB - INTRODUCTION: The aim of this study is to report the current status of ovarian tissue cryopreservation among alternatives for fertility preservation in the Nordic countries.MATERIAL AND METHODS: A questionnaire was sent to 14 Nordic academic reproductive centers with established fertility preservation programs. It covered fertility preservation cases performed up to December 2014, standard procedures for ovarian tissue cryopreservation and oocyte cryopreservation and reproductive outcomes following ovarian tissue transplantation.RESULTS: Among the Nordic countries, Denmark and Norway practice ovarian tissue cryopreservation as a clinical treatment (822 and 164 cases, respectively) and their programs are centralized. In Sweden (457 cases), ovarian tissue cryopreservation is practiced at five of six centers and in Finland at all five centers (145 cases). Nearly all considered ovarian tissue cryopreservation to be experimental. In Iceland, embryo cryopreservation is the only option for fertility preservation. Most centers use slow-freezing methods for ovarian tissue cryopreservation. Most patients selected for ovarian tissue cryopreservation were newly diagnosed with cancer and the tissue was predominantly retrieved laparoscopically by unilateral oophorectomy. Only minor complications were reported. In total, 46 women have undergone ovarian tissue transplantation aiming at recovering fertility, 17 healthy children have been born and several additional pregnancies are currently ongoing. Whenever patients' clinical condition is permissive, oocyte cryopreservation after hormonal stimulation is preferred for fertility preservation. Between 2012 and 2014, a smaller proportion of females have undergone fertility preservation in the Nordic centers, in comparison to males (1:3).CONCLUSIONS: Overall, ovarian tissue cryopreservation was reported to be safe. Slow freezing methods are still preferred. Promising results of recovery of fertility have been reported in Nordic countries that have initiated ovarian tissue transplantation procedures.

KW - Cryopreservation

KW - Embryo, Mammalian

KW - Female

KW - Fertility Preservation

KW - Hospitals, University

KW - Humans

KW - Oocytes

KW - Ovary

KW - Scandinavian and Nordic Countries

KW - Surveys and Questionnaires

KW - Journal Article

KW - Multicenter Study

U2 - 10.1111/aogs.12934

DO - 10.1111/aogs.12934

M3 - Journal article

C2 - 27258933

SN - 0001-6349

VL - 95

SP - 1015

EP - 1026

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 9

ER -

Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries - compilation of 20 years of multicenter experience

Abstract

Keywords

UN SDGs

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