Ovarian Clear Cell Carcinoma: From Morphology to Molecular Biology

Giuseppina Improta; Angela Pettinato; Estrid Høgdall; Giuseppe Santeusanio; Simona Vatrano; Filippo Fraggetta; Gian Franco Zannoni

doi:10.1097/PAI.0000000000000662

Ovarian Clear Cell Carcinoma: From Morphology to Molecular Biology

Giuseppina Improta, Angela Pettinato, Estrid Høgdall, Giuseppe Santeusanio, Simona Vatrano, Filippo Fraggetta, Gian Franco Zannoni

Department of Clinical Medicine

Abstract

Ovarian clear cell carcinoma (oCCC) is a distinctive subtype of ovarian carcinoma, with peculiar genetic and environmental risk factors, precursor lesions, molecular events during oncogenesis, patterns of spread, and response to treatment. Because of low response to chemotherapy and poor prognosis in advanced stages, there is growing interest in investigating the molecular pathways involved in oCCC development, in order to individualize novel/molecular targeted therapies. Until now, the main molecular genetic changes associated with oCCC remain to be identified, and, although several molecular changes have been reported in clear cell tumors, most studies have analyzed a limited number of cases; therefore, the true prevalence of those changes is not known. The present review will present the clinicopathologic features of oCCC, from morphology to molecular biology, discussing the diagnostic and treatment challenges of this intriguing ovarian carcinoma.

Original language	English
Journal	Applied Immunohistochemistry & Molecular Morphology
ISSN	1541-2016
DOIs	https://doi.org/10.1097/PAI.0000000000000662
Publication status	Published - 1 Oct 2019

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title = "Ovarian Clear Cell Carcinoma: From Morphology to Molecular Biology",

abstract = "Ovarian clear cell carcinoma (oCCC) is a distinctive subtype of ovarian carcinoma, with peculiar genetic and environmental risk factors, precursor lesions, molecular events during oncogenesis, patterns of spread, and response to treatment. Because of low response to chemotherapy and poor prognosis in advanced stages, there is growing interest in investigating the molecular pathways involved in oCCC development, in order to individualize novel/molecular targeted therapies. Until now, the main molecular genetic changes associated with oCCC remain to be identified, and, although several molecular changes have been reported in clear cell tumors, most studies have analyzed a limited number of cases; therefore, the true prevalence of those changes is not known. The present review will present the clinicopathologic features of oCCC, from morphology to molecular biology, discussing the diagnostic and treatment challenges of this intriguing ovarian carcinoma.",

author = "Giuseppina Improta and Angela Pettinato and Estrid H{\o}gdall and Giuseppe Santeusanio and Simona Vatrano and Filippo Fraggetta and Zannoni, {Gian Franco}",

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T1 - Ovarian Clear Cell Carcinoma

T2 - From Morphology to Molecular Biology

AU - Improta, Giuseppina

AU - Pettinato, Angela

AU - Høgdall, Estrid

AU - Santeusanio, Giuseppe

AU - Vatrano, Simona

AU - Fraggetta, Filippo

AU - Zannoni, Gian Franco

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Ovarian clear cell carcinoma (oCCC) is a distinctive subtype of ovarian carcinoma, with peculiar genetic and environmental risk factors, precursor lesions, molecular events during oncogenesis, patterns of spread, and response to treatment. Because of low response to chemotherapy and poor prognosis in advanced stages, there is growing interest in investigating the molecular pathways involved in oCCC development, in order to individualize novel/molecular targeted therapies. Until now, the main molecular genetic changes associated with oCCC remain to be identified, and, although several molecular changes have been reported in clear cell tumors, most studies have analyzed a limited number of cases; therefore, the true prevalence of those changes is not known. The present review will present the clinicopathologic features of oCCC, from morphology to molecular biology, discussing the diagnostic and treatment challenges of this intriguing ovarian carcinoma.

AB - Ovarian clear cell carcinoma (oCCC) is a distinctive subtype of ovarian carcinoma, with peculiar genetic and environmental risk factors, precursor lesions, molecular events during oncogenesis, patterns of spread, and response to treatment. Because of low response to chemotherapy and poor prognosis in advanced stages, there is growing interest in investigating the molecular pathways involved in oCCC development, in order to individualize novel/molecular targeted therapies. Until now, the main molecular genetic changes associated with oCCC remain to be identified, and, although several molecular changes have been reported in clear cell tumors, most studies have analyzed a limited number of cases; therefore, the true prevalence of those changes is not known. The present review will present the clinicopathologic features of oCCC, from morphology to molecular biology, discussing the diagnostic and treatment challenges of this intriguing ovarian carcinoma.

U2 - 10.1097/PAI.0000000000000662

DO - 10.1097/PAI.0000000000000662

M3 - Review

C2 - 29629954

SN - 1541-2016

JO - Applied Immunohistochemistry & Molecular Morphology

JF - Applied Immunohistochemistry & Molecular Morphology

ER -

Ovarian Clear Cell Carcinoma: From Morphology to Molecular Biology

Abstract

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