Outpatient treatment of alcohol use disorders among subjects 60+ years: design of a randomized clinical trial conducted in three countries (Elderly Study)

Kjeld Andersen; Michael P Bogenschutz; Gerhard Bühringer; Silke Behrendt; Randi Bilberg; Barbara Braun; Claus Thorn Ekstrøm; Alyssa Forcehimes; Christine Lizarraga; Theresa B Moyers; Anette Søgaard Nielsen

doi:10.1186/s12888-015-0672-x

Outpatient treatment of alcohol use disorders among subjects 60+ years: design of a randomized clinical trial conducted in three countries (Elderly Study)

Kjeld Andersen, Michael P Bogenschutz, Gerhard Bühringer, Silke Behrendt, Randi Bilberg, Barbara Braun, Claus Thorn Ekstrøm, Alyssa Forcehimes, Christine Lizarraga, Theresa B Moyers, Anette Søgaard Nielsen

Section of Biostatistics

26 Citations (Scopus)

Abstract

Background: The proportion of 60+ years with excessive alcohol intake varies in western countries between 6-16 % among men and 2-7 % among women. Specific events related to aging (e.g. loss of job, physical and mental capacity, or spouse) may contribute to onset or continuation of alcohol use disorders (AUD). We present the rationale and design of a multisite, multinational AUD treatment study for subjects aged 60+ years. Methods/Design: 1,000 subjects seeking treatment for AUD according to DSM-5 in outpatient clinics in Denmark, Germany, and New Mexico (USA) are invited to participate in a RCT. Participants are randomly assigned to four sessions of Motivational Enhancement Treatment (MET) or to MET plus an add-on with eight sessions based on the Community Reinforcement Approach (CRA), which include a new module targeting specific problems of older adults. A series of assessment instruments is applied, including the Form-90, Alcohol Dependence Scale, Penn Alcohol Craving Scale, Brief Symptom Inventory and WHO Quality of Life. Enrolment will be completed by April 2016 and data collection by April 2017. The primary outcome is the proportion in each group who are abstinent or have a controlled use of alcohol six months after treatment initiation. Controlled use is defined as maximum blood alcohol content not exceeding 0.05 % during the last month. Total abstinence is a secondary outcome, together with quality of life andcompliance with treatment. Discussion: The study will provide new knowledge about brief treatment of AUD for older subjects. As the treatment is manualized and applied in routine treatment facilities, barriers for implementation in the health care system are relatively low. Finally, as the study is being conducted in three different countries it will also provide significant insight into the possible interaction of service system differences and related patient characteristics in predictionof treatment outcome.

Original language	English
Article number	280
Journal	B M C Psychiatry
Volume	15
Pages (from-to)	1-11
Number of pages	11
ISSN	1471-244X
DOIs	https://doi.org/10.1186/s12888-015-0672-x
Publication status	Published - 14 Nov 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12888-015-0672-xLicence: CC BY

Cite this

Andersen, K., Bogenschutz, M. P., Bühringer, G., Behrendt, S., Bilberg, R., Braun, B., Ekstrøm, C. T., Forcehimes, A., Lizarraga, C., Moyers, T. B., & Søgaard Nielsen, A. (2015). Outpatient treatment of alcohol use disorders among subjects 60+ years: design of a randomized clinical trial conducted in three countries (Elderly Study). B M C Psychiatry, 15, 1-11. [280]. https://doi.org/10.1186/s12888-015-0672-x

Outpatient treatment of alcohol use disorders among subjects 60+ years : design of a randomized clinical trial conducted in three countries (Elderly Study). / Andersen, Kjeld; Bogenschutz, Michael P; Bühringer, Gerhard et al.

In: B M C Psychiatry, Vol. 15, 280, 14.11.2015, p. 1-11.

Research output: Contribution to journal › Journal article › Research › peer-review

Andersen, K, Bogenschutz, MP, Bühringer, G, Behrendt, S, Bilberg, R, Braun, B, Ekstrøm, CT, Forcehimes, A, Lizarraga, C, Moyers, TB & Søgaard Nielsen, A 2015, 'Outpatient treatment of alcohol use disorders among subjects 60+ years: design of a randomized clinical trial conducted in three countries (Elderly Study)', B M C Psychiatry, vol. 15, 280, pp. 1-11. https://doi.org/10.1186/s12888-015-0672-x

@article{9d0d59afff434b2f81e8dc9bb2b5c6f4,

title = "Outpatient treatment of alcohol use disorders among subjects 60+ years: design of a randomized clinical trial conducted in three countries (Elderly Study)",

abstract = "Background: The proportion of 60+ years with excessive alcohol intake varies in western countries between 6-16 % among men and 2-7 % among women. Specific events related to aging (e.g. loss of job, physical and mental capacity, or spouse) may contribute to onset or continuation of alcohol use disorders (AUD). We present the rationale and design of a multisite, multinational AUD treatment study for subjects aged 60+ years. Methods/Design: 1,000 subjects seeking treatment for AUD according to DSM-5 in outpatient clinics in Denmark, Germany, and New Mexico (USA) are invited to participate in a RCT. Participants are randomly assigned to four sessions of Motivational Enhancement Treatment (MET) or to MET plus an add-on with eight sessions based on the Community Reinforcement Approach (CRA), which include a new module targeting specific problems of older adults. A series of assessment instruments is applied, including the Form-90, Alcohol Dependence Scale, Penn Alcohol Craving Scale, Brief Symptom Inventory and WHO Quality of Life. Enrolment will be completed by April 2016 and data collection by April 2017. The primary outcome is the proportion in each group who are abstinent or have a controlled use of alcohol six months after treatment initiation. Controlled use is defined as maximum blood alcohol content not exceeding 0.05 % during the last month. Total abstinence is a secondary outcome, together with quality of life andcompliance with treatment. Discussion: The study will provide new knowledge about brief treatment of AUD for older subjects. As the treatment is manualized and applied in routine treatment facilities, barriers for implementation in the health care system are relatively low. Finally, as the study is being conducted in three different countries it will also provide significant insight into the possible interaction of service system differences and related patient characteristics in predictionof treatment outcome.",

author = "Kjeld Andersen and Bogenschutz, {Michael P} and Gerhard B{\"u}hringer and Silke Behrendt and Randi Bilberg and Barbara Braun and Ekstr{\o}m, {Claus Thorn} and Alyssa Forcehimes and Christine Lizarraga and Moyers, {Theresa B} and {S{\o}gaard Nielsen}, Anette",

year = "2015",

month = nov,

day = "14",

doi = "10.1186/s12888-015-0672-x",

language = "English",

volume = "15",

pages = "1--11",

journal = "B M C Psychiatry",

issn = "1471-244X",

publisher = "BioMed Central Ltd.",

}

TY - JOUR

T1 - Outpatient treatment of alcohol use disorders among subjects 60+ years

T2 - design of a randomized clinical trial conducted in three countries (Elderly Study)

AU - Andersen, Kjeld

AU - Bogenschutz, Michael P

AU - Bühringer, Gerhard

AU - Behrendt, Silke

AU - Bilberg, Randi

AU - Braun, Barbara

AU - Ekstrøm, Claus Thorn

AU - Forcehimes, Alyssa

AU - Lizarraga, Christine

AU - Moyers, Theresa B

AU - Søgaard Nielsen, Anette

PY - 2015/11/14

Y1 - 2015/11/14

N2 - Background: The proportion of 60+ years with excessive alcohol intake varies in western countries between 6-16 % among men and 2-7 % among women. Specific events related to aging (e.g. loss of job, physical and mental capacity, or spouse) may contribute to onset or continuation of alcohol use disorders (AUD). We present the rationale and design of a multisite, multinational AUD treatment study for subjects aged 60+ years. Methods/Design: 1,000 subjects seeking treatment for AUD according to DSM-5 in outpatient clinics in Denmark, Germany, and New Mexico (USA) are invited to participate in a RCT. Participants are randomly assigned to four sessions of Motivational Enhancement Treatment (MET) or to MET plus an add-on with eight sessions based on the Community Reinforcement Approach (CRA), which include a new module targeting specific problems of older adults. A series of assessment instruments is applied, including the Form-90, Alcohol Dependence Scale, Penn Alcohol Craving Scale, Brief Symptom Inventory and WHO Quality of Life. Enrolment will be completed by April 2016 and data collection by April 2017. The primary outcome is the proportion in each group who are abstinent or have a controlled use of alcohol six months after treatment initiation. Controlled use is defined as maximum blood alcohol content not exceeding 0.05 % during the last month. Total abstinence is a secondary outcome, together with quality of life andcompliance with treatment. Discussion: The study will provide new knowledge about brief treatment of AUD for older subjects. As the treatment is manualized and applied in routine treatment facilities, barriers for implementation in the health care system are relatively low. Finally, as the study is being conducted in three different countries it will also provide significant insight into the possible interaction of service system differences and related patient characteristics in predictionof treatment outcome.

AB - Background: The proportion of 60+ years with excessive alcohol intake varies in western countries between 6-16 % among men and 2-7 % among women. Specific events related to aging (e.g. loss of job, physical and mental capacity, or spouse) may contribute to onset or continuation of alcohol use disorders (AUD). We present the rationale and design of a multisite, multinational AUD treatment study for subjects aged 60+ years. Methods/Design: 1,000 subjects seeking treatment for AUD according to DSM-5 in outpatient clinics in Denmark, Germany, and New Mexico (USA) are invited to participate in a RCT. Participants are randomly assigned to four sessions of Motivational Enhancement Treatment (MET) or to MET plus an add-on with eight sessions based on the Community Reinforcement Approach (CRA), which include a new module targeting specific problems of older adults. A series of assessment instruments is applied, including the Form-90, Alcohol Dependence Scale, Penn Alcohol Craving Scale, Brief Symptom Inventory and WHO Quality of Life. Enrolment will be completed by April 2016 and data collection by April 2017. The primary outcome is the proportion in each group who are abstinent or have a controlled use of alcohol six months after treatment initiation. Controlled use is defined as maximum blood alcohol content not exceeding 0.05 % during the last month. Total abstinence is a secondary outcome, together with quality of life andcompliance with treatment. Discussion: The study will provide new knowledge about brief treatment of AUD for older subjects. As the treatment is manualized and applied in routine treatment facilities, barriers for implementation in the health care system are relatively low. Finally, as the study is being conducted in three different countries it will also provide significant insight into the possible interaction of service system differences and related patient characteristics in predictionof treatment outcome.

U2 - 10.1186/s12888-015-0672-x

DO - 10.1186/s12888-015-0672-x

M3 - Journal article

C2 - 26573323

SN - 1471-244X

VL - 15

SP - 1

EP - 11

JO - B M C Psychiatry

JF - B M C Psychiatry

M1 - 280

ER -

Outpatient treatment of alcohol use disorders among subjects 60+ years: design of a randomized clinical trial conducted in three countries (Elderly Study)

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this