Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts

Ole Raaschou-Nielsen; Marie Pedersen; Massimo Stafoggia; Gudrun Weinmayr; Zorana J. Andersen; Claudia Galassi; Johan Sommar; Bertil Forsberg; David Olsson; Bente Oftedal; Norun H. Krog; Gunn Marit Aasvang; Andrei Pyko; Göran Pershagen; Michal Korek; Ulf De Faire; Nancy L. Pedersen; Claes-Göran Östenson; Laura Fratiglioni; Mette Sørensen; Kirsten T. Eriksen; Anne Tjønneland; Petra H. Peeters; H. B(as) Bueno-de-Mesquita; Michelle Plusquin; Timothy J. Key; Andrea Jaensch; Gabriele Nagel; Bernhard Föger; Meng Wang; Ming-Yi Tsai; Sara Grioni; Alessandro Marcon; Vittorio Krogh; Fulvio Ricceri; Carlotta Sacerdote; Enrica Migliore; Ibon Tamayo; Pilar Amiano; Miren Dorronsoro; Ranjeet Sokhi; Ingeborg Kooter; Kees de Hoogh; Rob Beelen; Marloes Eeftens; Roel Vermeulen; Paolo Vineis; Bert Brunekreef; Gerard Hoek

doi:10.1002/ijc.30587

Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts

Ole Raaschou-Nielsen, Marie Pedersen, Massimo Stafoggia, Gudrun Weinmayr, Zorana J. Andersen, Claudia Galassi, Johan Sommar, Bertil Forsberg, David Olsson, Bente Oftedal, Norun H. Krog, Gunn Marit Aasvang, Andrei Pyko, Göran Pershagen, Michal Korek, Ulf De Faire, Nancy L. Pedersen, Claes-Göran Östenson, Laura Fratiglioni, Mette SørensenKirsten T. Eriksen, Anne Tjønneland, Petra H. Peeters, H. B(as) Bueno-de-Mesquita, Michelle Plusquin, Timothy J. Key, Andrea Jaensch, Gabriele Nagel, Bernhard Föger, Meng Wang, Ming-Yi Tsai, Sara Grioni, Alessandro Marcon, Vittorio Krogh, Fulvio Ricceri, Carlotta Sacerdote, Enrica Migliore, Ibon Tamayo, Pilar Amiano, Miren Dorronsoro, Ranjeet Sokhi, Ingeborg Kooter, Kees de Hoogh, Rob Beelen, Marloes Eeftens, Roel Vermeulen, Paolo Vineis, Bert Brunekreef, Gerard Hoek

Center of Epidemiology and Screening

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Abstract

Several studies have indicated weakly increased risk for kidney cancer among occupational groups exposed to gasoline vapors, engine exhaust, polycyclic aromatic hydrocarbons and other air pollutants, although not consistently. It was the aim to investigate possible associations between outdoor air pollution at the residence and the incidence of kidney parenchyma cancer in the general population. We used data from 14 European cohorts from the ESCAPE study. We geocoded and assessed air pollution concentrations at baseline addresses by land-use regression models for particulate matter (PM10 , PM2.5 , PMcoarse , PM2.5 absorbance (soot)) and nitrogen oxides (NO2 , NOx ), and collected data on traffic. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses to calculate summary hazard ratios (HRs). The 289,002 cohort members contributed 4,111,908 person-years at risk. During follow-up (mean 14.2 years) 697 incident cancers of the kidney parenchyma were diagnosed. The meta-analyses showed higher HRs in association with higher PM concentration, e.g. HR = 1.57 (95%CI: 0.81-3.01) per 5 μg/m(3) PM2.5 and HR = 1.36 (95%CI: 0.84-2.19) per 10(-5) m(-1) PM2.5 absorbance, albeit never statistically significant. The HRs in association with nitrogen oxides and traffic density on the nearest street were slightly above one. Sensitivity analyses among participants who did not change residence during follow-up showed stronger associations, but none were statistically significant. Our study provides suggestive evidence that exposure to outdoor PM at the residence may be associated with higher risk for kidney parenchyma cancer; the results should be interpreted cautiously as associations may be due to chance.

Original language	English
Journal	International Journal of Cancer
Volume	140
Issue number	7
Pages (from-to)	1528–1537
Number of pages	10
ISSN	0020-7136
DOIs	https://doi.org/10.1002/ijc.30587
Publication status	Published - 1 Apr 2017

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Raaschou-Nielsen, O., Pedersen, M., Stafoggia, M., Weinmayr, G., Andersen, Z. J., Galassi, C., Sommar, J., Forsberg, B., Olsson, D., Oftedal, B., Krog, N. H., Aasvang, G. M., Pyko, A., Pershagen, G., Korek, M., De Faire, U., Pedersen, N. L., Östenson, C-G., Fratiglioni, L., ... Hoek, G. (2017). Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts. International Journal of Cancer, 140(7), 1528–1537. https://doi.org/10.1002/ijc.30587

Raaschou-Nielsen, O, Pedersen, M, Stafoggia, M, Weinmayr, G, Andersen, ZJ, Galassi, C, Sommar, J, Forsberg, B, Olsson, D, Oftedal, B, Krog, NH, Aasvang, GM, Pyko, A, Pershagen, G, Korek, M, De Faire, U, Pedersen, NL, Östenson, C-G, Fratiglioni, L, Sørensen, M, Eriksen, KT, Tjønneland, A, Peeters, PH, Bueno-de-Mesquita, HB, Plusquin, M, Key, TJ, Jaensch, A, Nagel, G, Föger, B, Wang, M, Tsai, M-Y, Grioni, S, Marcon, A, Krogh, V, Ricceri, F, Sacerdote, C, Migliore, E, Tamayo, I, Amiano, P, Dorronsoro, M, Sokhi, R, Kooter, I, de Hoogh, K, Beelen, R, Eeftens, M, Vermeulen, R, Vineis, P, Brunekreef, B & Hoek, G 2017, 'Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts', International Journal of Cancer, vol. 140, no. 7, pp. 1528–1537. https://doi.org/10.1002/ijc.30587

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title = "Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts",

abstract = "Several studies have indicated weakly increased risk for kidney cancer among occupational groups exposed to gasoline vapors, engine exhaust, polycyclic aromatic hydrocarbons and other air pollutants, although not consistently. It was the aim to investigate possible associations between outdoor air pollution at the residence and the incidence of kidney parenchyma cancer in the general population. We used data from 14 European cohorts from the ESCAPE study. We geocoded and assessed air pollution concentrations at baseline addresses by land-use regression models for particulate matter (PM10 , PM2.5 , PMcoarse , PM2.5 absorbance (soot)) and nitrogen oxides (NO2 , NOx ), and collected data on traffic. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses to calculate summary hazard ratios (HRs). The 289,002 cohort members contributed 4,111,908 person-years at risk. During follow-up (mean 14.2 years) 697 incident cancers of the kidney parenchyma were diagnosed. The meta-analyses showed higher HRs in association with higher PM concentration, e.g. HR = 1.57 (95%CI: 0.81-3.01) per 5 μg/m(3) PM2.5 and HR = 1.36 (95%CI: 0.84-2.19) per 10(-5) m(-1) PM2.5 absorbance, albeit never statistically significant. The HRs in association with nitrogen oxides and traffic density on the nearest street were slightly above one. Sensitivity analyses among participants who did not change residence during follow-up showed stronger associations, but none were statistically significant. Our study provides suggestive evidence that exposure to outdoor PM at the residence may be associated with higher risk for kidney parenchyma cancer; the results should be interpreted cautiously as associations may be due to chance.",

author = "Ole Raaschou-Nielsen and Marie Pedersen and Massimo Stafoggia and Gudrun Weinmayr and Andersen, {Zorana J.} and Claudia Galassi and Johan Sommar and Bertil Forsberg and David Olsson and Bente Oftedal and Krog, {Norun H.} and Aasvang, {Gunn Marit} and Andrei Pyko and G{\"o}ran Pershagen and Michal Korek and {De Faire}, Ulf and Pedersen, {Nancy L.} and Claes-G{\"o}ran {\"O}stenson and Laura Fratiglioni and Mette S{\o}rensen and Eriksen, {Kirsten T.} and Anne Tj{\o}nneland and Peeters, {Petra H.} and Bueno-de-Mesquita, {H. B(as)} and Michelle Plusquin and Key, {Timothy J.} and Andrea Jaensch and Gabriele Nagel and Bernhard F{\"o}ger and Meng Wang and Ming-Yi Tsai and Sara Grioni and Alessandro Marcon and Vittorio Krogh and Fulvio Ricceri and Carlotta Sacerdote and Enrica Migliore and Ibon Tamayo and Pilar Amiano and Miren Dorronsoro and Ranjeet Sokhi and Ingeborg Kooter and {de Hoogh}, Kees and Rob Beelen and Marloes Eeftens and Roel Vermeulen and Paolo Vineis and Bert Brunekreef and Gerard Hoek",

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T1 - Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts

AU - Raaschou-Nielsen, Ole

AU - Pedersen, Marie

AU - Stafoggia, Massimo

AU - Weinmayr, Gudrun

AU - Andersen, Zorana J.

AU - Galassi, Claudia

AU - Sommar, Johan

AU - Forsberg, Bertil

AU - Olsson, David

AU - Oftedal, Bente

AU - Krog, Norun H.

AU - Aasvang, Gunn Marit

AU - Pyko, Andrei

AU - Pershagen, Göran

AU - Korek, Michal

AU - De Faire, Ulf

AU - Pedersen, Nancy L.

AU - Östenson, Claes-Göran

AU - Fratiglioni, Laura

AU - Sørensen, Mette

AU - Eriksen, Kirsten T.

AU - Tjønneland, Anne

AU - Peeters, Petra H.

AU - Bueno-de-Mesquita, H. B(as)

AU - Plusquin, Michelle

AU - Key, Timothy J.

AU - Jaensch, Andrea

AU - Nagel, Gabriele

AU - Föger, Bernhard

AU - Wang, Meng

AU - Tsai, Ming-Yi

AU - Grioni, Sara

AU - Marcon, Alessandro

AU - Krogh, Vittorio

AU - Ricceri, Fulvio

AU - Sacerdote, Carlotta

AU - Migliore, Enrica

AU - Tamayo, Ibon

AU - Amiano, Pilar

AU - Dorronsoro, Miren

AU - Sokhi, Ranjeet

AU - Kooter, Ingeborg

AU - de Hoogh, Kees

AU - Beelen, Rob

AU - Eeftens, Marloes

AU - Vermeulen, Roel

AU - Vineis, Paolo

AU - Brunekreef, Bert

AU - Hoek, Gerard

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Several studies have indicated weakly increased risk for kidney cancer among occupational groups exposed to gasoline vapors, engine exhaust, polycyclic aromatic hydrocarbons and other air pollutants, although not consistently. It was the aim to investigate possible associations between outdoor air pollution at the residence and the incidence of kidney parenchyma cancer in the general population. We used data from 14 European cohorts from the ESCAPE study. We geocoded and assessed air pollution concentrations at baseline addresses by land-use regression models for particulate matter (PM10 , PM2.5 , PMcoarse , PM2.5 absorbance (soot)) and nitrogen oxides (NO2 , NOx ), and collected data on traffic. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses to calculate summary hazard ratios (HRs). The 289,002 cohort members contributed 4,111,908 person-years at risk. During follow-up (mean 14.2 years) 697 incident cancers of the kidney parenchyma were diagnosed. The meta-analyses showed higher HRs in association with higher PM concentration, e.g. HR = 1.57 (95%CI: 0.81-3.01) per 5 μg/m(3) PM2.5 and HR = 1.36 (95%CI: 0.84-2.19) per 10(-5) m(-1) PM2.5 absorbance, albeit never statistically significant. The HRs in association with nitrogen oxides and traffic density on the nearest street were slightly above one. Sensitivity analyses among participants who did not change residence during follow-up showed stronger associations, but none were statistically significant. Our study provides suggestive evidence that exposure to outdoor PM at the residence may be associated with higher risk for kidney parenchyma cancer; the results should be interpreted cautiously as associations may be due to chance.

AB - Several studies have indicated weakly increased risk for kidney cancer among occupational groups exposed to gasoline vapors, engine exhaust, polycyclic aromatic hydrocarbons and other air pollutants, although not consistently. It was the aim to investigate possible associations between outdoor air pollution at the residence and the incidence of kidney parenchyma cancer in the general population. We used data from 14 European cohorts from the ESCAPE study. We geocoded and assessed air pollution concentrations at baseline addresses by land-use regression models for particulate matter (PM10 , PM2.5 , PMcoarse , PM2.5 absorbance (soot)) and nitrogen oxides (NO2 , NOx ), and collected data on traffic. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses to calculate summary hazard ratios (HRs). The 289,002 cohort members contributed 4,111,908 person-years at risk. During follow-up (mean 14.2 years) 697 incident cancers of the kidney parenchyma were diagnosed. The meta-analyses showed higher HRs in association with higher PM concentration, e.g. HR = 1.57 (95%CI: 0.81-3.01) per 5 μg/m(3) PM2.5 and HR = 1.36 (95%CI: 0.84-2.19) per 10(-5) m(-1) PM2.5 absorbance, albeit never statistically significant. The HRs in association with nitrogen oxides and traffic density on the nearest street were slightly above one. Sensitivity analyses among participants who did not change residence during follow-up showed stronger associations, but none were statistically significant. Our study provides suggestive evidence that exposure to outdoor PM at the residence may be associated with higher risk for kidney parenchyma cancer; the results should be interpreted cautiously as associations may be due to chance.

U2 - 10.1002/ijc.30587

DO - 10.1002/ijc.30587

M3 - Journal article

C2 - 28006861

SN - 0020-7136

VL - 140

SP - 1528

EP - 1537

JO - Radiation Oncology Investigations

JF - Radiation Oncology Investigations

IS - 7

ER -

Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts

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